{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T22:10:05Z","timestamp":1717279805365},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2014,8,25]],"date-time":"2014-08-25T00:00:00Z","timestamp":1408924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute of Health","award":["R01-AI095068"],"award-info":[{"award-number":["R01-AI095068"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biometrics"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:label\/><jats:p>The performance of diagnostic tests for disease classification is often measured by accuracy (e.g., sensitivity or specificity); however, costs of the diagnostic test are a concern as well. Combinations of multiple diagnostic tests may improve accuracy, but incur additional costs. Here, we consider serial testing approaches that maintain accuracy while controlling costs of the diagnostic tests. We present a serial risk score classification approach. The basic idea is to sequentially test with additional diagnostic tests just until persons are classified. In this way, it is not necessary to test all persons with all tests. The methods are studied in simulations and compared with logistic regression. We applied the methods to data from HIV cohort studies to identify HIV infected individuals who are recently infected (<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/biom12217-math-0001.gif\" xlink:title=\"urn:x-wiley:15410420:media:biom12217:biom12217-math-0001\"\/>1 year) by testing with assays for multiple biomarkers. We find that the serial risk score classification approach can maintain accuracy while achieving a reduction in cost compared to testing all individuals with all assays.<\/jats:p><\/jats:sec>","DOI":"10.1111\/biom.12217","type":"journal-article","created":{"date-parts":[[2014,8,25]],"date-time":"2014-08-25T14:16:55Z","timestamp":1408976215000},"page":"1042-1051","source":"Crossref","is-referenced-by-count":7,"title":["A serial risk score approach to disease classification that accounts for accuracy and cost"],"prefix":"10.1093","volume":"70","author":[{"given":"Dat","family":"Huynh","sequence":"first","affiliation":[{"name":"Department of Biostatistics University of California Los Angeles California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Laeyendecker","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Institute of Allergy and Infectious Diseases, National Institutes of Health Johns Hopkins University School of Medicine Baltimore Maryland U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Brookmeyer","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of California Los Angeles California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,8,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws436"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3182986fdf"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/317658"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1109\/TIT.1970.1054406"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1983.10477973"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-4541-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/4.4.523"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/03610920601126514"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/126.2.310"},{"key":"e_1_2_8_11_1","unstructured":"Kim H.(2013). Sequential neutral zone classifier. Unpublished paper presented at Quality and Productivity Research Conference 2013."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis659"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2002.00657.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199901140-00015"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181f1afbc"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198509844.001.0001","volume-title":"The Statistical Evaluation of Medical Tests for Classification and Prediction","author":"Pepe M. 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