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For instance, it may be that there is a subgroup of individuals with a certain disease who differ from the rest of the population based on the expression profile for only a subset of genes. Identifying the subgroup of patients and subset of genes could lead to better\u2010targeted therapy. We can represent the subgroup of individuals and genes as a bicluster, a submatrix, , of a larger data matrix, , such that the features and observations in  differ from those not contained in . We present a novel two\u2010step method, SC\u2010Biclust, for identifying . In the first step, the observations in the bicluster are identified to maximize the sum of the weighted between\u2010cluster feature differences. In the second step, features in the bicluster are identified based on their contribution to the clustering of the observations. This versatile method can be used to identify biclusters that differ on the basis of feature means, feature variances, or more general differences. The bicluster identification accuracy of SC\u2010Biclust is illustrated through several simulated studies. Application of SC\u2010Biclust to pain research illustrates its ability to identify biologically meaningful subgroups.<\/jats:p>","DOI":"10.1111\/biom.13136","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T10:57:25Z","timestamp":1566212245000},"page":"348-358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Biclustering via sparse clustering"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5170-7100","authenticated-orcid":false,"given":"Erika S.","family":"Helgeson","sequence":"first","affiliation":[{"name":"Division of Biostatistics University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of North Carolina Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9314-2037","authenticated-orcid":false,"given":"Guanhua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics University of Wisconsin\u2010Madison Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6070-9738","authenticated-orcid":false,"given":"Michael R.","family":"Kosorok","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of North Carolina Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bair","sequence":"additional","affiliation":[{"name":"Departments of Endodontics and Biostatistics University of North Carolina Chapel Hill North 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