{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:48:11Z","timestamp":1792133291173,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T00:00:00Z","timestamp":1423526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vaginal infection in early pregnancy is associated with preterm birth. This study evaluates long\u2010term results after integrating an antenatal screen\u2010and\u2010treat program for asymptomatic vaginal infections into routine pregnancy care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed data of all women with singleton high\u2010risk pregnancies delivering at our tertiary referral center between 2005 and 2014. The intervention group included women who presented for a prenatal visit for a planned birth between 10\u00a0+\u00a00 and 16\u00a0+\u00a00 gestational weeks. Women were routinely screened for asymptomatic infections using Gram stain. In cases of bacterial vaginosis, candidiasis or trichomoniasis, women were treated according to our clinical protocol. The control group included women who did not undergo the program. Prenatal care was equal in both groups. Preterm birth served as the primary outcome variable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 20,052 women with singleton pregnancies, 8,490 (42.3%) participated in the antenatal prevention program. The mean gestational age at birth was 38.8\u00a0\u00b1\u00a02.6\u00a0weeks and 37.5\u00a0\u00b1\u00a04.3\u00a0weeks in the intervention and control groups, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). The incidence of preterm birth was significantly lower in the intervention group than in the control group (9.7% vs 22.3%;\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001). Low\u2010birthweight neonates, stillbirths, and late miscarriages were less frequent in the intervention group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Long\u2010term results support the use of an antenatal infection screen\u2010and\u2010treat program to prevent preterm birth. If integrated into routine pregnancy care at a high\u2010risk obstetrical setting, this simple public health intervention could lead to a significant reduction in preterm birth, low infant birthweight, and adverse pregnancy outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/birt.12154","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T13:16:08Z","timestamp":1423746968000},"page":"173-180","source":"Crossref","is-referenced-by-count":38,"title":["Routine Use of an Antenatal Infection Screen\u2010and\u2010Treat Program to Prevent Preterm Birth: Long\u2010Term Experience at a Tertiary Referral Center"],"prefix":"10.1111","volume":"42","author":[{"given":"Alex","family":"Farr","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Obstetrics and Fetomaternal Medicine Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Obstetrics and Fetomaternal Medicine Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hagmann","sequence":"additional","affiliation":[{"name":"Section for Medical Statistics (IMS) Center of Medical Statistics Informatics and Intelligent Systems Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Marschalek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Obstetrics and Fetomaternal Medicine Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Husslein","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Obstetrics and Fetomaternal Medicine Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljubomir","family":"Petricevic","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Obstetrics and Fetomaternal Medicine Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt251"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2214.2001.00203.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.339"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01120.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12823-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2004.02.038"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38169.519653.EB"},{"key":"e_1_2_6_10_1","unstructured":"NICHD.What Are the Factors that Put a Pregnancy at Risk?Accessed September 22 2014. 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