{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:46:48Z","timestamp":1792619208682,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T00:00:00Z","timestamp":1520467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["836011020"],"award-info":[{"award-number":["836011020"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Depression and anxiety during pregnancy are associated with adverse health outcomes for both mother and child. This study aims to investigate the occurrence of symptoms of depression and anxiety in early and late pregnancy, the longitudinal changes from early to late pregnancy, and factors associated with symptoms of depression and anxiety in pregnant women in the Netherlands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 2897 women participating in the PRegnancy and Infant DEvelopment (PRIDE) Study. To assess symptoms of depression and anxiety, web\u2010based questionnaires including the Hospital Anxiety and Depression Scale (HADS) and multiple questions on maternal characteristics were completed in early and late pregnancy. Cross\u2010sectional and longitudinal multivariable linear regression analyses were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The depressive symptoms in our population increased, with a prevalence of probable depression from 5.4% in early pregnancy to 10.0% in late pregnancy (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), whereas the anxiety symptoms decreased, with a prevalence of probable anxiety from 17.9% to 14.2% (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Characteristics associated with depressive or anxiety symptoms included low level of education, multiparity, a history of depression, severe nausea, extreme fatigue, lack of physical exercise, and negative life events. Being non\u2010Dutch, not living with a partner, and having an unplanned pregnancy or a long time to pregnancy were associated with the depressive and\/or anxiety symptoms in early pregnancy only.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Symptoms of depression and anxiety are common in both early and late pregnancy. Screening for risk factors in early pregnancy is important, since prenatal depression and anxiety may be related to adverse maternal and child health outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/birt.12343","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T06:04:39Z","timestamp":1520489079000},"page":"478-489","source":"Crossref","is-referenced-by-count":113,"title":["Depression and anxiety during pregnancy: The influence of maternal characteristics"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9030-8302","authenticated-orcid":false,"given":"Kim F. E.","family":"van de Loo","sequence":"first","affiliation":[{"name":"Department of Medical Psychology Radboud Institute for Health Sciences Radboudumc Amalia Children's Hospital Radboud university medical center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richelle","family":"Vlenterie","sequence":"additional","affiliation":[{"name":"Department for Health Evidence Radboud Institute for Health Sciences Radboud university medical center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylke J.","family":"Nikkels","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Radboudumc Amalia Children's Hospital Radboud university medical center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J. F. M.","family":"Merkus","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pulmonology Radboudumc Amalia Children's Hospital Radboud university medical center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolt","family":"Roukema","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pulmonology Radboudumc Amalia Children's Hospital Radboud university medical center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris M.","family":"Verhaak","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology Radboud Institute for Health Sciences Radboudumc Amalia Children's Hospital Radboud university medical center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nel","family":"Roeleveld","sequence":"additional","affiliation":[{"name":"Department for Health Evidence Radboud Institute for Health Sciences Radboud university medical center  Nijmegen The Netherlands"},{"name":"Department of Paediatrics Radboudumc Amalia Children's Hospital Radboud university medical center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen M. H. J.","family":"van Gelder","sequence":"additional","affiliation":[{"name":"Department for Health Evidence Radboud Institute for Health Sciences Radboud university medical center  Nijmegen The Netherlands"},{"name":"Radboud REshape Innovation Center Radboud university medical center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050701209560"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e3283503680"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.03.022"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wombi.2011.09.002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2014.12.003"},{"key":"e_1_2_6_7_1","first-page":"1","article-title":"Trajectories of maternal depression: a 27\u2010year population\u2010based prospective study","volume":"26","author":"Najman JM","year":"2016","journal-title":"Epidemiol Psychiatr Sci"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.01.039"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000287065.59491.70"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000183597.31630.db"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000116689.75396.5f"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-015-0671-y"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.07.018"},{"key":"e_1_2_6_14_1","first-page":"173","article-title":"The influence of sociodemografic and medical variables on severity of anxiety and depressive symptoms during particular trimesters of pregnancy","volume":"48","author":"Morylowska\u2010Topolska J","year":"2014","journal-title":"Psychiatr Pol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.27.1.43"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-200109000-00004"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.11.014"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2004.02.006"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12023"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.165.5.669"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(01)00296-3"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291796004382"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(67)90010-4"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(68)90018-4"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/0097840X.1978.9934972"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2009.01062.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.3847"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-005-0090-z"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.044"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.01.012"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1017\/S109285290000897X"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2012.03.021"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/652630"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-013-0334-2"},{"key":"e_1_2_6_36_1","first-page":"470","article-title":"Physical activity among pregnant women in relation to pregnancy\u2010related complaints and symptoms of depression","volume":"122","author":"Nordhagen IH","year":"2002","journal-title":"Tidsskr Nor Laegeforen"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20777"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-015-0511-6"}],"container-title":["Birth"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbirt.12343","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/birt.12343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T09:13:40Z","timestamp":1694769220000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/birt.12343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,8]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/birt.12343"],"URL":"https:\/\/doi.org\/10.1111\/birt.12343","archive":["Portico"],"relation":{},"ISSN":["0730-7659","1523-536X"],"issn-type":[{"value":"0730-7659","type":"print"},{"value":"1523-536X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,8]]}}}