{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:06:04Z","timestamp":1761491164267,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The incidence of acidosis in term and healthy newborns and the consequences for their neurodevelopment are poorly understood. The aim of our study was to assess neurodevelopmental outcomes at 24\u00a0months of age via a parental questionnaire (ASQ, Ages and Stages Questionnaires) for a sample of infants born at term with an umbilical arterial blood pH\u00a0\u2264\u00a07 or\/and hyperlactacidemia\u00a0\u2265\u00a07\u00a0mmol\/L. In addition, we compared these groups\u2019 neurodevelopmental outcomes with a control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During the 29\u00a0months of the study, we retrospectively included all children who had an umbilical artery (UA) cord blood pH\u00a0\u2264\u00a07 and\/or lactates\u00a0\u2265\u00a07\u00a0mmol\/L with good clinical adaptation. We also included a control group of term newborns with normal gases at birth. Ages and Stages questionnaires were sent to parents at 24\u00a0months of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 9016 births during the study, 7.1% of babies had a UA pH\u00a0\u2264\u00a07 and\/or lactates\u00a0\u2265\u00a07\u00a0mmol\/L. The ASQ was considered non\u2010optimal for 32.2% and 36.3% of respondents in the acidosis and control group, respectively, without any significant difference (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.382). After matching for gestational age and sex, there was also no significant difference in the rate of non\u2010optimal ASQ. The percentage of abnormal communication was significantly higher in the control group (19.7% vs 11.4%, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Isolated biochemical umbilical cord blood abnormalities in term or near\u2010term newborns with good adaptation do not appear to have a long\u2010term impact on development. These results are rather reassuring, and the absence of specific follow\u2010up for these children seems reasonable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/birt.12527","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T02:29:27Z","timestamp":1611887367000},"page":"178-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Neurodevelopmental outcome at 24 months of healthy infants at birth with an umbilical artery blood pH\u00a0\u2264\u00a07 and\/or hyperlactacidemia\u00a0\u2265\u00a07\u00a0mmol\/L"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5740-4677","authenticated-orcid":false,"given":"Cl\u00e9mence","family":"Dain","sequence":"first","affiliation":[{"name":"Department of Neonatal Medicine Departmental Hospital Centre of Vendee La Roche sur Yon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010christophe","family":"Roze","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine Nantes University Hospital Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Olivier","sequence":"additional","affiliation":[{"name":"Loire Infant Follow\u2010up Team\u201d (LIFT) Network Pays De Loire France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margot","family":"Bossard","sequence":"additional","affiliation":[{"name":"Maternity Hospital Cholet Hospital Center Cholet France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Praud","sequence":"additional","affiliation":[{"name":"Liberal Midwife Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyril","family":"Flamant","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine Nantes University Hospital Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.319.7216.1054"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1471"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2831"},{"issue":"10","key":"e_1_2_6_5_1","first-page":"1010","article-title":"Two\u2010year outcomes for infants with low cord pH at birth","volume":"27","author":"Kayani SI","year":"2014","journal-title":"J Matern\u2010Fetal Neonatal Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb10934.x"},{"issue":"1","key":"e_1_2_6_7_1","first-page":"16","article-title":"Postnatal lactate as an early predictor of short\u2010term outcome after intrapartum 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