{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T02:24:09Z","timestamp":1783736649629,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,20]],"date-time":"2022-02-20T00:00:00Z","timestamp":1645315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1004604"],"award-info":[{"award-number":["2018YFC1004604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2018\u201002667"],"award-info":[{"award-number":["2018\u201002667"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2018\u201002682"],"award-info":[{"award-number":["2018\u201002682"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011447","name":"Science and Technology Department of Henan Province","doi-asserted-by":"publisher","award":["171100310200"],"award-info":[{"award-number":["171100310200"]}],"id":[{"id":"10.13039\/501100011447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801305"],"award-info":[{"award-number":["81801305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M652590"],"award-info":[{"award-number":["2019M652590"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Preterm complications and neonatal asphyxia are the leading causes of death in those under 5\u00a0years of age. However, little information exists for the province of Henan, China. The purpose of this study was to explore changes in the live birth profile in a provincial hospital over the past 32\u00a0years in Henan, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted to reveal the characteristics of live neonates from 1987 to 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 118\u00a0253 live births during the period, including 19\u00a0798 (16.74%) preterm births. The neonatal death rate was 6.45\u2030, and the top risk factor was preterm birth complications and birth asphyxia. Before 1998, neonatal death occurred primarily among term infants. Between 1999 and 2018, preterm infants, especially extreme and very preterm infants with very low birthweight, constituted more than half of all mortalities, and the preterm birth rate increased from 5.94% in 1999 to 16.69% in 2018. The risk factors associated with preterm birth were being male (aOR\u00a0=\u00a01.18, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), advanced maternal age (&gt;35\u00a0years old; aOR\u00a0=\u00a01.08, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008), gravidity \u22652 (aOR\u00a0=\u00a01.15, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), parity \u22652 (aOR\u00a0=\u00a01.50, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), placenta previa (aOR\u00a0=\u00a07.41, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), twin or multiple births (aOR\u00a0=\u00a010.63, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), hypertension (aOR\u00a0=\u00a02.08, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and rupture of membrane (aOR\u00a0=\u00a05.03, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The preterm birth rate has increased over the past 32\u00a0years from 4.98% to 16.69% in a provincial hospital in China. Preterm birth was the leading reason for neonatal death, and birth asphyxia was the major risk factor for death in term infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/birt.12620","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T05:44:06Z","timestamp":1645422246000},"page":"497-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Changes in the live birth profile in Henan, China: A\u00a0hospital registry\u2010based study"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5111-9405","authenticated-orcid":false,"given":"Xiaoli","family":"Zhang","sequence":"first","affiliation":[{"name":"Henan Key Laboratory of Child Brain Injury Institute of Neuroscience Third Affiliated Hospital of Zhengzhou University  Zhengzhou 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Institute of Neuroscience Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Ding","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Child Brain Injury Institute of Neuroscience Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Gao","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Child Brain Injury Institute of Neuroscience Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Third Affiliated Hospital of Zhengzhou University  Zhengzhou 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