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This review investigates the cost\u2010effectiveness of interventions tackling these problems, assesses the methodological quality of included studies, and indicates suggestions for further research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen databases were searched for economic evaluations of interventions related to antenatal, perinatal, and postnatal mental health conditions, published between 2000 and September 2021, in high\u2010income countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010nine studies met all inclusion criteria. Interventions considered were screening programs, pharmacological treatments, and various forms of psychosocial and psychological support. Six studies reported that the intervention was cost\u2010saving. Eighteen were cost\u2010effective and seven likely to be cost\u2010effective. Only six studies included health outcomes for the child; one study considered paternal health. The time horizon for which costs and consequences were considered was for most evaluations limited to 1\u00a0year (n\u00a0=\u00a018) or 2\u00a0years (n\u00a0=\u00a011) postpartum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Given the importance of the subject, a relatively low number of studies have investigated the cost\u2010effectiveness of interventions tackling mental health problems during and after pregnancy. The scant evidence available suggests good overall value for money. Likely, cost\u2010effectiveness is underestimated as costly long\u2010term consequences on offspring are systematically excluded. No evidence was found for several frequently occurring conditions. Further research is required to obtain reliable, long\u2010term effectiveness data and to address the methodological challenges related to measuring all relevant health outcomes for all parties affected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/birt.12623","type":"journal-article","created":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T23:02:32Z","timestamp":1648162952000},"page":"364-402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Cost\u2010effectiveness of mental health interventions during and after pregnancy: A systematic review"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9520-3991","authenticated-orcid":false,"given":"Evelyn","family":"Verbeke","sequence":"first","affiliation":[{"name":"Department of Public Health and Primary Care Leuven Institute for Healthcare Policy, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2718-4682","authenticated-orcid":false,"given":"Annick","family":"Bogaerts","sequence":"additional","affiliation":[{"name":"Department of Development &amp; Regeneration, Women &amp; Child, REALIFE research group Faculty of Medicine KU Leuven  Leuven Belgium"},{"name":"Faculty of Medicine and Health Sciences Centre for Research and Innovation in Care (CRIC) University of Antwerp  Antwerp Belgium"},{"name":"Faculty of Health University of Plymouth  Devon PL4 8AA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0627-0354","authenticated-orcid":false,"given":"Tinne","family":"Nuyts","sequence":"additional","affiliation":[{"name":"Department of Development &amp; Regeneration, Women &amp; Child, REALIFE research group Faculty of Medicine KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6808-0874","authenticated-orcid":false,"given":"Neeltje","family":"Crombag","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, Urogenital, Abdominal and Plastic Surgery KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6398-4025","authenticated-orcid":false,"given":"Jeroen","family":"Luyten","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care Leuven Institute for Healthcare Policy, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"World Health Organization.WHO | Maternal mental health [Internet].2020. 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