{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T14:33:38Z","timestamp":1743086018710},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The association between birth order and adverse perinatal outcomes has been well studied in twin pregnancies. However, little is known about the differences in immediate perinatal outcomes as well as long\u2010term hospitalization of the offspring in triplet pregnancies according to their birth order. As such, we aimed to assess the differences in immediate perinatal outcomes and long\u2010term hospitalizations among triplets by their birth order.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective hospital\u2010based cohort study, immediate perinatal outcomes and long\u2010term hospitalizations were compared among triplet siblings according to their birth order. Deliveries occurred between the years 1991 and 2021 in a tertiary medical center. The study groups were followed until 18\u2009years of age for cardiovascular, respiratory, neurological, and infection\u2010related hospitalizations. Generalized estimation equation (GEE) models were used to control for confounders. Kaplan\u2013Meier survival curves were used to compare cumulative long\u2010term hospitalization incidences and Cox proportional hazards models were performed to control for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 117 triplet deliveries. Rates of small for gestational age (SGA) infants increased linearly by birth order (6.0%, 7.7%, and 15.4% for the first, second, and third siblings, respectively; <jats:italic>p<\/jats:italic>\u2010value for trends\u2009=\u20090.035). Using a GEE model controlling for maternal age, being born third in a triplet pregnancy was independently associated with SGA (third vs. first sibling, adjusted OR 3.0, 95% CI 1.38\u20136.59, <jats:italic>p<\/jats:italic>\u2009=\u20090.005). No significant differences in cardiovascular, respiratory, neurological, and infection\u2010related hospitalizations were noted among the first, second, and third siblings. Likewise, using Kaplan\u2013Meier survival analyses, no significant differences in the cumulative incidence of long\u2010term pediatric hospitalizations were noted between the siblings. In Cox proportional hazards models, controlling for weight and gender, birth order in a triplet pregnancy did not exhibit an association with long\u2010term hospitalizations of the offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the association between birth order and SGA, birth order in triplets does not seem to have an impact on the risk for long\u2010term offspring hospitalization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/birt.12798","type":"journal-article","created":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T03:39:42Z","timestamp":1700278782000},"page":"424-431","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Perinatal outcome and long\u2010term hospitalization of triplets according to birth order"],"prefix":"10.1111","volume":"51","author":[{"given":"David Nadav","family":"Sabag","sequence":"first","affiliation":[{"name":"Joyce and Irving Goldman Medical School, Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"},{"name":"Department of Obstetrics and Gynecology, Soroka University Medical Center Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gali","family":"Pariente","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Soroka University Medical Center Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Sheiner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Soroka University Medical Center Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayna","family":"Miodownik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Soroka University Medical Center Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Wainstock","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.05.012"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001709"},{"issue":"1","key":"e_1_2_6_4_1","first-page":"1","article-title":"Births: final data for 2009","volume":"60","author":"Martin JA","year":"2011","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-200304000-00005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004397"},{"issue":"13","key":"e_1_2_6_7_1","first-page":"1","article-title":"Births: final data for 2018","volume":"68","author":"Martin JA","year":"2019","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000059372"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493191"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2004.04.014"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7210950"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2018.1514490"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340801934276"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/147670505000132484"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000227747.37184.0a"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.02.079"},{"key":"e_1_2_6_17_1","unstructured":"Statistics TCBo.Israel in figures\u00a02021.https:\/\/www.cbs.gov.il\/he\/publications\/doclib\/2021\/2.shnatonpopulation\/st02_18x.pdf. 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