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The concept of schizotypy represents a broader framework for investigating risk for schizophrenia (and other disorders) in childhood, before the onset of prodromal or overt symptoms. We sought to detect profiles of risk for psychosis (schizotypy) in a general population sample of 22,137 Australian children aged 11\u201312\u2009years, and to determine early life risk factors associated with these profiles from data available in linked records (registers).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010nine self\u2010reported items were used as indicators of schizotypy across six broad domains;\n                      <jats:italic>z<\/jats:italic>\n                      \u2010scores for each domain were subjected to latent profile analyses (LPA). A series of multinomial logistic regressions was used to examine the association between resulting profile (class) membership and several childhood and parental risk factors, and the proportion of children with mental disorders among each schizotypy profile was examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The LPA revealed three person\u2010centred profiles referred to as\n                      <jats:italic>True Schizotypy<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091,323; 6.0%),\n                      <jats:italic>Introverted Schizotypy<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094,473; 20.2%), and\n                      <jats:italic>Affective Schizotypy<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094,261; 19.2%), as well as a group of children showing no risk (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912,080; 54.6%). Prior exposure to perinatal and familial adversities including childhood maltreatment, as well as poor early childhood development and academic functioning, was variously associated with all risk groups. There was a higher proportion of childhood mental disorder diagnoses among children in the\n                      <jats:italic>True Schizotypy<\/jats:italic>\n                      group, relative to other profiles.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Subtle differences in the pattern of exposures and antecedents among schizophrenia liability profiles in childhood may reflect distinct pathogenic pathways to psychotic or other mental illness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practitioner points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Children aged 11\u201312\u2009years report characteristics of schizotypy which can be classified into three distinct profiles that may represent different pathological processes towards later mental ill\u2010health.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Early life exposure to perinatal and familial adversities including childhood maltreatment, early childhood developmental vulnerability, and poor academic functioning predict membership in all three childhood schizotypy profiles.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Latent liability for schizophrenia (and potentially other mental disorders) may be represented by different profiles of functioning observable in childhood.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bjc.12363","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T04:00:28Z","timestamp":1646107228000},"page":"836-858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Developmental profiles of schizotypy in the general population: A record linkage study of Australian children aged 11\u201312\u2009years"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9361-4874","authenticated-orcid":false,"given":"Melissa J.","family":"Green","sequence":"first","affiliation":[{"name":"Discipline of Psychiatry and Mental Health University of New South Wales  Kensington New South Wales Australia"},{"name":"Neuroscience Research Australia  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirstie","family":"O\u2019Hare","sequence":"additional","affiliation":[{"name":"Discipline of Psychiatry and Mental Health University of New South Wales  Kensington New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin R.","family":"Laurens","sequence":"additional","affiliation":[{"name":"Discipline of Psychiatry and Mental Health University of New South Wales  Kensington New South Wales Australia"},{"name":"School of Psychology and Counselling Queensland University of Technology (QUT)  Brisbane City Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacy","family":"Tzoumakis","sequence":"additional","affiliation":[{"name":"School of Criminology and Criminal Justice Griffith University  Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberlie","family":"Dean","sequence":"additional","affiliation":[{"name":"Discipline of Psychiatry and Mental Health University of New South Wales  Kensington New South Wales Australia"},{"name":"Justice Health &amp; Forensic Mental Health Network  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna C.","family":"Badcock","sequence":"additional","affiliation":[{"name":"School of Psychological Science University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicity","family":"Harris","sequence":"additional","affiliation":[{"name":"Discipline of Psychiatry and Mental Health University of New South Wales  Kensington New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Linscott","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Otago  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaughan J.","family":"Carr","sequence":"additional","affiliation":[{"name":"Discipline of Psychiatry and Mental Health University of New South Wales  Kensington New South Wales Australia"},{"name":"Neuroscience Research Australia  Sydney New South Wales Australia"},{"name":"Department of Psychiatry School of Clinical Sciences Monash University  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"The Australian Curriculum Assessment and Reporting Authority (ACARA). 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