{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:45:44Z","timestamp":1790628344308,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspsychub.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Clinic Psychol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Generalized anxiety disorder (GAD) is associated with the lowest treatment response rate among all anxiety disorders. Understanding mechanisms of improvement may help to develop more effective and personalized treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The objective of the study was to investigate different improvement mechanisms in the treatment of individuals diagnosed with GAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>We reported data from a randomized controlled trial that evaluated three different GAD treatments (mindfulness\u2010based intervention, BMT; fluoxetine, FLX; and an active comparison group, QoL) for 8\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Mediation analyses were performed evaluating the association between worry symptoms at baseline and anxiety scoring at the endpoint, considering self\u2010compassion or mindfulness or its dimensions at mid\u2010treatment as mediators for the whole sample (assessing GAD improvement mechanism) and the different interventions as moderators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Contrary to mindfulness state scoring (\n                      <jats:italic>C<\/jats:italic>\n                      \u00a0=\u2009.06; 95% CI\u00a0=\u00a0\u2212.05 to .20), self\u2010compassion (\n                      <jats:italic>C<\/jats:italic>\n                      \u00a0=\u2009.11; 95% CI\u00a0=\u00a0.01 to .28) and non\u2010judgement of inner experience (\n                      <jats:italic>C<\/jats:italic>\n                      \u00a0=\u2009.10; 95% CI\u00a0=\u00a0.004 to .21) mediated the association between worry symptoms at baseline and anxiety at the endpoint. When comparing BMT to FLX, the intervention modality did not moderate these associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Self\u2010compassion and non\u2010judgement of inner experience seem to be essential targets in GAD treatment, contrary to the mindfulness state itself. Although no difference was found considering the intervention modality, future research may assess how to boost these dimensions in specific treatments for GAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bjc.12402","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T01:45:26Z","timestamp":1669772726000},"page":"196-208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mechanisms of improvement in generalized anxiety disorder: A mediation and moderated mediation analysis from a randomized controlled trial"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0303-943X","authenticated-orcid":false,"given":"Marianna de Abreu","family":"Costa","sequence":"first","affiliation":[{"name":"Anxiety Disorders Outpatient Program (PROTAN), Hospital de Cl\u00ednicas de Porto Alegre (HCPA) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil"},{"name":"Graduate Program in Psychiatry and Behavioral Sciences, Hospital de Cl\u00ednicas de Porto Alegre (HCPA) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara A.","family":"Russell","sequence":"additional","affiliation":[{"name":"Neuroimaging Department, Institute of Psychiatry, Psychology and Neuroscience King's College London London UK"},{"name":"British Psychological Society London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natan Pereira","family":"Gosmann","sequence":"additional","affiliation":[{"name":"Anxiety Disorders Outpatient Program (PROTAN), Hospital de Cl\u00ednicas de Porto Alegre (HCPA) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil"},{"name":"Graduate Program in Psychiatry and Behavioral Sciences, Hospital de Cl\u00ednicas de Porto Alegre (HCPA) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil"},{"name":"Section of Negative Affect and Social Processes, Hospital de Cl\u00ednicas de Porto Alegre (HCPA) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Anxiety Disorders Outpatient Program (PROTAN), Hospital de Cl\u00ednicas de Porto Alegre (HCPA) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil"},{"name":"Graduate Program in Psychiatry and Behavioral Sciences, Hospital de Cl\u00ednicas de Porto Alegre (HCPA) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Tatton\u2010Ramos","sequence":"additional","affiliation":[{"name":"Iniciativa Mindfulness (Brazil) Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Borges","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Anxiety Disorders Outpatient Program (PROTAN), Hospital de Cl\u00ednicas de Porto Alegre (HCPA) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele Gus","family":"Manfro","sequence":"additional","affiliation":[{"name":"Anxiety Disorders Outpatient Program (PROTAN), Hospital de Cl\u00ednicas de Porto Alegre (HCPA) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil"},{"name":"Graduate Program in Psychiatry and Behavioral Sciences, Hospital de Cl\u00ednicas de Porto Alegre (HCPA) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2013.12.018"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073191105283504"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102\u201037722014000300009"},{"key":"e_1_2_12_5_1","volume-title":"Terapia cognitivo\u2010comportamental: Teoria e pr\u00e1tica (2a edi\u00e7\u00e3o)","author":"Beck J. 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