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We investigated whether relationships between early childhood developmental vulnerabilities and childhood schizotypy are mediated by educational underachievement in middle childhood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants were members of a large Australian (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a019,216) population cohort followed longitudinally. Path analyses were used to model relationships between developmental vulnerabilities at age ~5\u2009years, educational underachievement from ages ~8 to 10\u2009years and three distinct profiles of schizotypy at age ~11\u2009years (\n                      <jats:italic>true<\/jats:italic>\n                      ,\n                      <jats:italic>introverted<\/jats:italic>\n                      and\n                      <jats:italic>affective schizotypy<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Early childhood developmental vulnerabilities on five broad domains (related to physical, emotional, social, cognitive and communication development) were associated with schizotypy profiles in middle childhood. Educational underachievement in middle childhood was associated with all schizotypy profiles, but most strongly with the\n                      <jats:italic>true schizotypy<\/jats:italic>\n                      profile (OR\u00a0=\u00a03.92, 95% CI\u00a0=\u00a03.12, 4.91). The relationships between schizotypy profiles and early childhood developmental vulnerabilities in \u2018language and cognitive skills (school\u2010based)\u2019 and \u2018communication skills and general knowledge\u2019 domains were fully mediated by educational underachievement in middle childhood, and the relationships with early childhood \u2018physical health and well\u2010being\u2019 and \u2018emotional maturity\u2019 domains were partially mediated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Developmental continuity from early childhood developmental vulnerabilities to schizotypy in middle childhood is mediated by educational underachievement in middle childhood. While some domains of early developmental functioning showed differential relationships with distinct schizotypy profiles, these findings support a developmental pathway to schizotypy in which cognitive vulnerability operates from early childhood through to middle childhood.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bjc.12405","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T06:01:22Z","timestamp":1669960882000},"page":"228-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pathways from developmental vulnerabilities in early childhood to schizotypy in middle childhood"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1166-9792","authenticated-orcid":false,"given":"Kirstie","family":"O'Hare","sequence":"first","affiliation":[{"name":"Discipline of Psychiatry and Mental Health, School of Clinical Medicine University of New South Wales Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Watkeys","sequence":"additional","affiliation":[{"name":"Discipline of Psychiatry and Mental Health, School of Clinical Medicine University of New South Wales Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna C.","family":"Badcock","sequence":"additional","affiliation":[{"name":"School of Psychological Science University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin R.","family":"Laurens","sequence":"additional","affiliation":[{"name":"Discipline of Psychiatry and Mental Health, School of Clinical Medicine University of New South Wales Sydney NSW Australia"},{"name":"School of Psychology and Counselling Queensland University of Technology (QUT) Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacy","family":"Tzoumakis","sequence":"additional","affiliation":[{"name":"Discipline of Psychiatry and Mental Health, School of Clinical Medicine University of New South Wales Sydney NSW Australia"},{"name":"School of Criminology and Criminal Justice Griffith University Southport Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberlie","family":"Dean","sequence":"additional","affiliation":[{"name":"Discipline of Psychiatry and Mental Health, School of Clinical Medicine University of New South Wales Sydney NSW Australia"},{"name":"Justice Health and Forensic Mental Health Network Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicity","family":"Harris","sequence":"additional","affiliation":[{"name":"Discipline of Psychiatry and Mental Health, School of Clinical Medicine University of New South Wales Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaughan J.","family":"Carr","sequence":"additional","affiliation":[{"name":"Discipline of Psychiatry and Mental Health, School of Clinical Medicine University of New South Wales Sydney NSW Australia"},{"name":"Neuroscience Research Australia Sydney NSW Australia"},{"name":"Department of Psychiatry Monash University Melbourne Vic. 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