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Given the substantial heterogeneity in OCD symptom presentations, examining changes in obsessive\u2010compulsive (O\u2010C) symptom profiles, rather than overall symptom severity, may clarify why patients respond differently to treatment. Accordingly, this study aimed to identify O\u2010C symptom profile classes across treatment and to characterize transitions between classes during EX\/RP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The sample included 152 patients with OCD from two clinical trials that delivered 17 twice\u2010weekly EX\/RP sessions over 8\u2009weeks, with assessments conducted at baseline, midpoint and post\u2010treatment. Latent profile analysis was used to identify O\u2010C symptom profiles at each time point, followed by latent transition analysis to examine how individuals transitioned between profile classes over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Distinct O\u2010C profiles were identified at each time point, reflecting varying severity across Obsessive\u2010Compulsive Inventory\u2010Revised\u00a0dimensions. Most patients maintained stable profiles with reduced overall symptom severity across treatment, supporting EX\/RP's effectiveness. However, some profiles\u2014particularly those characterized by elevated neutralizing symptoms\u2014showed more variable transitions. A novel profile emerged at midpoint, with lower baseline avoidance predicting the membership.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that meaningful clinical information is gained by monitoring changes in O\u2010C symptom profiles alongside overall severity during EX\/RP. In particular, elevated neutralizing symptoms may signal a more variable response, whereas hoarding elevations may warrant early identification and proactive planning for targeted strategies beyond standard EX\/RP. Incorporating profile\u2010based monitoring into clinical practice may help clinicians more precisely tailor EX\/RP to maximize therapeutic benefit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bjc.70059","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T09:53:03Z","timestamp":1777974783000},"page":"1163-1179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in obsessive\u2010compulsive symptom profiles in response to exposure and response prevention"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8120-4133","authenticated-orcid":false,"given":"Seung Yun","family":"Baek","sequence":"first","affiliation":[{"name":"Department of Psychology Sogang University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunsik","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychology Sogang University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Wheaton","sequence":"additional","affiliation":[{"name":"Department of Psychology Barnard College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Tyler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Center for the Treatment and Study of Anxiety University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edna","family":"Foa","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Center for the Treatment and Study of Anxiety University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen Blair","family":"Simpson","sequence":"additional","affiliation":[{"name":"New York State Psychiatric Institute  New York New York USA"},{"name":"Department of Psychiatry Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocrd.2020.100557"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2006.03.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02294359"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425787"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712000244"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2013.08.029"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2020.11.010"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20240"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.50"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7967(98)00135-1"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01246098"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2010.06.007"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.155.1.102"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0025579"},{"key":"e_1_2_11_17_1","unstructured":"First M. 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