{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:13:21Z","timestamp":1787505201846,"version":"build-2736575974"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":549,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Dermatol"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1111\/bjd.12635","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T06:45:12Z","timestamp":1394606712000},"page":"661-671","source":"Crossref","is-referenced-by-count":59,"title":["Increased risk and pattern of secondary malignancies in patients with invasive extramammary Paget disease"],"prefix":"10.1093","volume":"170","author":[{"given":"A.","family":"Karam","sequence":"first","affiliation":[{"name":"Stanford Women's Cancer Center; Division of Gynecologic Oncology; Stanford University; Stanford CA 94305 U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Dorigo","sequence":"additional","affiliation":[{"name":"Stanford Women's Cancer Center; Division of Gynecologic Oncology; Stanford University; Stanford CA 94305 U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,3,12]]},"reference":[{"key":"10.1111\/bjd.12635-BIB0001|bjd12635-cit-0001","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0190-9622(85)70254-X","article-title":"Extramammary Paget's disease: prognosis and relationship to internal malignancy","volume":"13","author":"Chanda","year":"1985","journal-title":"J Am Acad Dermatol"},{"issue":"1 Pt 1","key":"10.1111\/bjd.12635-BIB0002|bjd12635-cit-0002","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0002-9378(99)70143-2","article-title":"Paget's disease of the vulva: prevalence of associated vulvar adenocarcinoma, invasive Paget's disease, and recurrence after surgical excision","volume":"180","author":"Fanning","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"10.1111\/bjd.12635-BIB0003|bjd12635-cit-0003","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1159\/000249245","article-title":"Triple extramammary Paget's disease. Immunohistochemical studies","volume":"173","author":"Hashimoto","year":"1986","journal-title":"Dermatologica"},{"key":"10.1111\/bjd.12635-BIB0004|bjd12635-cit-0004","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1097\/01.PRS.0000076193.67701.6A","article-title":"Penoscrotal extramammary Paget's disease: a review of 33 cases in a 20-year experience","volume":"112","author":"Lai","year":"2003","journal-title":"Plast Reconstr Surg"},{"key":"10.1111\/bjd.12635-BIB0005|bjd12635-cit-0005","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/s10350-004-6618-x","article-title":"Long-term outcome of perianal Paget's disease","volume":"46","author":"McCarter","year":"2003","journal-title":"Dis Colon Rectum"},{"key":"10.1111\/bjd.12635-BIB0006|bjd12635-cit-0006","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1072-7515(02)01619-8","article-title":"Prognosis and management of extramammary Paget's disease and the association with secondary malignancies","volume":"196","author":"Pierie","year":"2003","journal-title":"J Am Coll Surg"},{"key":"10.1111\/bjd.12635-BIB0007|bjd12635-cit-0007","first-page":"507","article-title":"Bile duct cancer associated with extramammary Paget's disease","volume":"90","author":"Nakano","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"10.1111\/bjd.12635-BIB0008|bjd12635-cit-0008","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/gyno.1998.5136","article-title":"Synchronous Paget's disease of the vulva and breast","volume":"71","author":"Popiolek","year":"1998","journal-title":"Gynecol Oncol"},{"key":"10.1111\/bjd.12635-BIB0009|bjd12635-cit-0009","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.ejso.2006.11.028","article-title":"Epidemiology and treatment of extramammary Paget disease in the Netherlands","volume":"33","author":"Siesling","year":"2007","journal-title":"Eur J Surg Oncol"},{"key":"10.1111\/bjd.12635-BIB0010|bjd12635-cit-0010","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1468-3083.2007.02154.x","article-title":"Mammary and extramammary Paget's disease","volume":"21","author":"Kanitakis","year":"2007","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1111\/bjd.12635-BIB0011|bjd12635-cit-0011","first-page":"199","article-title":"Anorectal mucinous adenocarcinoma associated with latent perianal Paget's disease","volume":"85","author":"Sasaki","year":"1990","journal-title":"Am J Gastroenterol"},{"key":"10.1111\/bjd.12635-BIB0012|bjd12635-cit-0012","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1053\/hupa.2002.124788","article-title":"Vulvar Paget disease of urothelial origin: a report of three cases and a proposed classification of vulvar Paget disease","volume":"33","author":"Wilkinson","year":"2002","journal-title":"Hum Pathol"},{"key":"10.1111\/bjd.12635-BIB0013|bjd12635-cit-0013","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ygyno.2006.09.017","article-title":"The outcomes of patients with positive margins after excision for intraepithelial Paget's disease of the vulva","volume":"104","author":"Black","year":"2007","journal-title":"Gynecol Oncol"},{"key":"10.1111\/bjd.12635-BIB0014|bjd12635-cit-0014","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ygyno.2007.12.014","article-title":"HER-2\/neu targeting for recurrent vulvar Paget's disease. A case report and literature review","volume":"111","author":"Karam","year":"2008","journal-title":"Gynecol Oncol"},{"key":"10.1111\/bjd.12635-BIB0015|bjd12635-cit-0015","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1006\/gyno.1995.1010","article-title":"A clinicopathologic study of 30 patients with Paget's disease of the vulva","volume":"56","author":"Kodama","year":"1995","journal-title":"Gynecol Oncol"},{"key":"10.1111\/bjd.12635-BIB0016|bjd12635-cit-0016","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1006\/gyno.2000.5741","article-title":"Paget's disease of the vulva: pathology, pattern of involvement, and prognosis","volume":"77","author":"Parker","year":"2000","journal-title":"Gynecol Oncol"},{"key":"10.1111\/bjd.12635-BIB0017|bjd12635-cit-0017","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/cncr.22193","article-title":"Annual report to the nation on the status of cancer, 1975-2003, featuring cancer among U.S. Hispanic\/Latino populations","volume":"107","author":"Howe","year":"2006","journal-title":"Cancer"},{"key":"10.1111\/bjd.12635-BIB0018|bjd12635-cit-0018","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1002\/cncr.21803","article-title":"Estimates of long-term survival for newly diagnosed cancer patients: a projection approach","volume":"106","author":"Mariotto","year":"2006","journal-title":"Cancer"},{"key":"10.1111\/bjd.12635-BIB0019|bjd12635-cit-0019","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3324\/haematol.12585","article-title":"Secondary malignancies after therapy of indolent non-Hodgkin's lymphoma","volume":"93","author":"Friedberg","year":"2008","journal-title":"Haematologica"},{"key":"10.1111\/bjd.12635-BIB0020|bjd12635-cit-0020","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1093\/jnci\/dji290","article-title":"Cumulative absolute breast cancer risk for young women treated for Hodgkin lymphoma","volume":"97","author":"Travis","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"10.1111\/bjd.12635-BIB0021|bjd12635-cit-0021","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ejso.2011.12.008","article-title":"Invasive extramammary Paget's disease and the risk for secondary tumours in Europe","volume":"38","author":"Zwan","year":"2012","journal-title":"Eur J Surg Oncol"},{"key":"10.1111\/bjd.12635-BIB0022|bjd12635-cit-0022","unstructured":"Surveillance, Epidemiology, and End Results (WWW document) http:\/\/seer.cancer.gov\/about\/factsheets\/SEER_brochure.pdf"},{"key":"10.1111\/bjd.12635-BIB0023|bjd12635-cit-0023","first-page":"1117","article-title":"The surveillance, epidemiology, and end results program: a national resource","volume":"8","author":"Hankey","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1111\/bjd.12635-BIB0024|bjd12635-cit-0024","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1634\/theoncologist.12-1-20","article-title":"Cancer statistics, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) Program","volume":"12","author":"Hayat","year":"2007","journal-title":"Oncologist"},{"issue":"Suppl. 4","key":"10.1111\/bjd.12635-BIB0025|bjd12635-cit-0025","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1002\/1097-0142(197710)40:4+<1892::AID-CNCR2820400820>3.0.CO;2-H","article-title":"Statistical methods for studying multiple primary malignant neoplasms","volume":"40","author":"Schoenberg","year":"1977","journal-title":"Cancer"},{"key":"10.1111\/bjd.12635-BIB0026|bjd12635-cit-0026","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0010-4809(74)90010-X","article-title":"Analysis of relative survival and proportional mortality","volume":"7","author":"Monson","year":"1974","journal-title":"Comput Biomed Res"},{"key":"10.1111\/bjd.12635-BIB0027|bjd12635-cit-0027","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1001\/archdermatol.2010.2","article-title":"Increased risk of second primary cancers after a diagnosis of melanoma","volume":"146","author":"Bradford","year":"2010","journal-title":"Arch Dermatol"},{"key":"10.1111\/bjd.12635-BIB0028|bjd12635-cit-0028","volume-title":"Cancer Registry Management","author":"Hutchison","year":"1997"},{"key":"10.1111\/bjd.12635-BIB0029|bjd12635-cit-0029","volume-title":"Multiple Primary Cancers","author":"Neugut","year":"1999","edition":"13"},{"key":"10.1111\/bjd.12635-BIB0030|bjd12635-cit-0030","first-page":"359","article-title":"Perianal extramammary Paget's disease","volume":"167","author":"Berardi","year":"1988","journal-title":"Surg Gynecol Obstet"},{"key":"10.1111\/bjd.12635-BIB0031|bjd12635-cit-0031","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0090-8258(90)90016-E","article-title":"Vulvar Paget's disease: the need to exclude an invasive lesion","volume":"38","author":"Feuer","year":"1990","journal-title":"Gynecol Oncol"},{"key":"10.1111\/bjd.12635-BIB0032|bjd12635-cit-0032","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1365-2559.1989.tb02169.x","article-title":"The histogenesis of mammary and extramammary Paget's disease","volume":"14","author":"Jones","year":"1989","journal-title":"Histopathology"},{"key":"10.1111\/bjd.12635-BIB0033|bjd12635-cit-0033","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/DAD.0b013e318215c3fb","article-title":"Hematopoietic progenitor kinase 1, mitogen-activated protein\/extracellular signal-related protein kinase kinase kinase 1, and phosphomitogen-activated protein kinase kinase 4 are overexpressed in extramammary Paget disease","volume":"33","author":"Qian","year":"2011","journal-title":"Am J Dermatopathol"},{"key":"10.1111\/bjd.12635-BIB0034|bjd12635-cit-0034","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1111\/j.1525-1438.2006.00602.x","article-title":"Paget's disease of the vulva: clinicopathologic study of type 1 cases treated at a single institution","volume":"16","author":"Niikura","year":"2006","journal-title":"Int J Gynecol Cancer"},{"key":"10.1111\/bjd.12635-BIB0035|bjd12635-cit-0035","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3816\/CBC.2003.n.032","article-title":"Risk for the development of treatment-related acute myelocytic leukemia and myelodysplastic syndrome among patients with breast cancer: review of the literature and the National Surgical Adjuvant Breast and Bowel Project experience","volume":"4","author":"Smith","year":"2003","journal-title":"Clin Breast Cancer"},{"key":"10.1111\/bjd.12635-BIB0036|bjd12635-cit-0036","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0895-4356(99)00011-6","article-title":"Information on radiation treatment in patients with breast cancer: the advantages of the linked medicare and SEER data. Surveillance, Epidemiology and End Results","volume":"52","author":"Du","year":"1999","journal-title":"J Clin Epidemiol"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.12635","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/bjd.12635\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T19:19:35Z","timestamp":1716578375000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/170\/3\/661\/6614891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"URL":"https:\/\/doi.org\/10.1111\/bjd.12635","relation":{},"ISSN":["0007-0963"],"issn-type":[{"value":"0007-0963","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}