{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:49:18Z","timestamp":1790887758095,"version":"4.1.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":549,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Dermatol"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1111\/bjd.12702","type":"journal-article","created":{"date-parts":[[2013,10,27]],"date-time":"2013-10-27T11:50:03Z","timestamp":1382874603000},"page":"687-693","source":"Crossref","is-referenced-by-count":29,"title":["Altered global methylation and hydroxymethylation status in vulvar lichen sclerosus: further support for epigenetic mechanisms"],"prefix":"10.1093","volume":"170","author":[{"given":"T.","family":"Gambichler","sequence":"first","affiliation":[{"name":"Department of Dermatology; Ruhr-University Bochum; Gudrunstra\u00dfe 56 44791 Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Terras","sequence":"additional","affiliation":[{"name":"Department of Dermatology; Ruhr-University Bochum; Gudrunstra\u00dfe 56 44791 Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kreuter","sequence":"additional","affiliation":[{"name":"Department of Dermatology; Ruhr-University Bochum; Gudrunstra\u00dfe 56 44791 Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Skrygan","sequence":"additional","affiliation":[{"name":"Department of Dermatology; Ruhr-University Bochum; Gudrunstra\u00dfe 56 44791 Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,3,12]]},"reference":[{"key":"10.1111\/bjd.12702-BIB0001|bjd12702-cit-0001","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/S0140-6736(98)08228-2","article-title":"Lichen sclerosus","volume":"353","author":"Powell","year":"1999","journal-title":"Lancet"},{"key":"10.1111\/bjd.12702-BIB0002|bjd12702-cit-0002","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1067\/mjd.2002.118552","article-title":"Low-dose ultraviolet A1 phototherapy for extragenital lichen sclerosus: results of a preliminary study","volume":"46","author":"Kreuter","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.12702-BIB0003|bjd12702-cit-0003","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1365-2230.2006.02082.x","article-title":"UVA1 phototherapy for genital lichen sclerosus","volume":"31","author":"Beattie","year":"2006","journal-title":"Clin Exp Dermatol"},{"key":"10.1111\/bjd.12702-BIB0004|bjd12702-cit-0004","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.mrfmmm.2004.06.057","article-title":"Mutations induced by ultraviolet light","volume":"571","author":"Pfeifer","year":"2005","journal-title":"Mutat Res"},{"key":"10.1111\/bjd.12702-BIB0005|bjd12702-cit-0005","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.clindermatol.2013.01.011","article-title":"Treatment regimens, protocols, dosage and indications for UVA1 phototherapy: facts and controversies","volume":"31","author":"Gambichler","year":"2013","journal-title":"Clin Dermatol"},{"key":"10.1111\/bjd.12702-BIB0006|bjd12702-cit-0006","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.2217\/14622416.9.12.1835","article-title":"Epigenetics and dermatological disease","volume":"9","author":"Millington","year":"2008","journal-title":"Pharmacogenomics"},{"key":"10.1111\/bjd.12702-BIB0007|bjd12702-cit-0007","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/LGT.0b013e3182457fcc","article-title":"Promoter hypermethylation of death-associated protein kinase and p16 genes in vulvar lichen sclerosus","volume":"16","author":"Aid\u00e9","year":"2012","journal-title":"J Low Genit Tract Dis"},{"key":"10.1111\/bjd.12702-BIB0008|bjd12702-cit-0008","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1002\/ijc.25629","article-title":"Differential hypermethylation of genes in vulvar cancer and lichen sclerosus coexisting or not with vulvar cancer","volume":"128","author":"Guerrero","year":"2011","journal-title":"Int J Cancer"},{"key":"10.1111\/bjd.12702-BIB0009|bjd12702-cit-0009","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1053\/hupa.2002.129415","article-title":"Alterations of the p16\/Rb\/cyclin-D1 pathway in vulvar carcinoma, vulvar intraepithelial neoplasia, and lichen sclerosus","volume":"33","author":"Lerma","year":"2002","journal-title":"Hum Pathol"},{"key":"10.1111\/bjd.12702-BIB0010|bjd12702-cit-0010","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1039\/C1PP05197K","article-title":"UVA-induced epigenetic regulation of P16(INK4a) in human epidermal keratinocytes and skin tumor derived cells","volume":"11","author":"Chen","year":"2012","journal-title":"Photochem Photobiol Sci"},{"key":"10.1111\/bjd.12702-BIB0011|bjd12702-cit-0011","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1038\/sj.bjc.6601444","article-title":"TP53 mutations in vulval lichen sclerosus adjacent to squamous cell carcinoma of the vulva","volume":"89","author":"Rolfe","year":"2003","journal-title":"Br J Cancer"},{"key":"10.1111\/bjd.12702-BIB0012|bjd12702-cit-0012","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1038\/sj.jid.5700889","article-title":"Single base instability is promoted in vulvar lichen sclerosus","volume":"127","author":"Tapp","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.12702-BIB0013|bjd12702-cit-0013","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1111\/j.1751-1097.2011.01020.x","article-title":"Epigenetic alterations in ultraviolet radiation-induced skin carcinogenesis: interaction of bioactive dietary components on epigenetic targets","volume":"88","author":"Katiyar","year":"2012","journal-title":"Photochem Photobiol"},{"key":"10.1111\/bjd.12702-BIB0014|bjd12702-cit-0014","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-4419-9967-2_3","article-title":"Ten eleven translocation enzymes and 5-hydroxymethylation in mammalian development and cancer","volume":"754","author":"Kinney","year":"2013","journal-title":"Adv Exp Med Biol"},{"key":"10.1111\/bjd.12702-BIB0015|bjd12702-cit-0015","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/CMR.0b013e32835f9bd4","article-title":"Loss of 5-hydroxymethylcytosine and ten-eleven translocation 2 protein expression in malignant melanoma","volume":"23","author":"Gambichler","year":"2013","journal-title":"Melanoma Res"},{"key":"10.1111\/bjd.12702-BIB0016|bjd12702-cit-0016","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1021\/tx950182o","article-title":"Photochemical deamination and demethylation of 5-methylcytosine","volume":"9","author":"Privat","year":"1996","journal-title":"Chem Res Toxicol"},{"key":"10.1111\/bjd.12702-BIB0017|bjd12702-cit-0017","doi-asserted-by":"crossref","DOI":"10.1001\/jamadermatol.2013.7733","article-title":"Ultraviolet-A1 phototherapy versus clobetasol propionate 0.05% in the treatment of vulvar lichen sclerosus. A randomized controlled study","author":"Terras","year":"2014","journal-title":"JAMA Dermatol"},{"key":"10.1111\/bjd.12702-BIB0018|bjd12702-cit-0018","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.regpep.2011.02.003","article-title":"Cell cycle regulation and proliferation in lichen sclerosus","volume":"167","author":"Gambichler","year":"2011","journal-title":"Regul Pept"},{"key":"10.1111\/bjd.12702-BIB0019|bjd12702-cit-0019","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-61779-612-8_1","article-title":"Epigenetic markers of early tumor development","volume":"863","author":"Dumitrescu","year":"2012","journal-title":"Methods Mol Biol"},{"key":"10.1111\/bjd.12702-BIB0020|bjd12702-cit-0020","doi-asserted-by":"crossref","first-page":"e52672","DOI":"10.1371\/journal.pone.0052672","article-title":"Identification of epigenetically altered genes in sporadic amyotrophic lateral sclerosis","volume":"7","author":"Figueroa-Romero","year":"2012","journal-title":"PLoS One"},{"key":"10.1111\/bjd.12702-BIB0021|bjd12702-cit-0021","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1039\/c3pp50037c","article-title":"Formation of cyclobutane pyrimidine dimers at dipyrimidines containing 5-hydroxymethylcytosine","volume":"12","author":"Kim","year":"2013","journal-title":"Photochem Photobiol Sci"},{"key":"10.1111\/bjd.12702-BIB0022|bjd12702-cit-0022","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1756-8935-6-10","article-title":"5-Hydroxymethylcytosine and its potential roles in development and cancer","volume":"6","author":"Pfeifer","year":"2013","journal-title":"Epigenetics Chromatin"},{"key":"10.1111\/bjd.12702-BIB0023|bjd12702-cit-0023","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1006\/bbrc.2002.6667","article-title":"Cellular defense against UVB-induced phototoxicity by cytosolic NADP(+)-dependent isocitrate dehydrogenase","volume":"292","author":"Jo","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/bjd.12702-BIB0024|bjd12702-cit-0024","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/jid.2011.369","article-title":"An autoimmune phenotype in vulvar lichen sclerosus and lichen planus: a Th1 response and high levels of microRNA-155","volume":"132","author":"Terlou","year":"2012","journal-title":"J Invest Dermatol"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.12702","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/bjd.12702\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T14:07:30Z","timestamp":1676383650000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/170\/3\/687\/6614851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"URL":"https:\/\/doi.org\/10.1111\/bjd.12702","relation":{},"ISSN":["0007-0963"],"issn-type":[{"value":"0007-0963","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}