{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T02:07:51Z","timestamp":1769911671335,"version":"3.49.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":549,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Dermatol"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1111\/bjd.12706","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T13:05:51Z","timestamp":1383051951000},"page":"557-564","source":"Crossref","is-referenced-by-count":16,"title":["Systematic review on the rapidity of the onset of action of topical treatments in the therapy of mild-to-moderate acne vulgaris"],"prefix":"10.1093","volume":"170","author":[{"given":"A.","family":"Jacobs","sequence":"first","affiliation":[{"name":"Division of Evidence Based Medicine (dEBM); Department of Dermatology; Charit\u00e9-Universit\u00e4tsmedizin Berlin; Charit\u00e9platz 1 10117 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Starke","sequence":"additional","affiliation":[{"name":"Division of Evidence Based Medicine (dEBM); Department of Dermatology; Charit\u00e9-Universit\u00e4tsmedizin Berlin; Charit\u00e9platz 1 10117 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Rosumeck","sequence":"additional","affiliation":[{"name":"Division of Evidence Based Medicine (dEBM); Department of Dermatology; Charit\u00e9-Universit\u00e4tsmedizin Berlin; Charit\u00e9platz 1 10117 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nast","sequence":"additional","affiliation":[{"name":"Division of Evidence Based Medicine (dEBM); Department of Dermatology; Charit\u00e9-Universit\u00e4tsmedizin Berlin; Charit\u00e9platz 1 10117 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,3,12]]},"reference":[{"key":"10.1111\/bjd.12706-BIB0001|bjd12706-cit-0001","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/jdv.12053","article-title":"Which factors influence quality of life in acne patients?","volume":"28","author":"Zauli","year":"2014","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1111\/bjd.12706-BIB0002|bjd12706-cit-0002","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s40257-013-0016-x","article-title":"Medication adherence, healthcare costs and utilization associated with acne drugs in Medicaid enrollees with acne vulgaris","volume":"14","author":"Tan","year":"2013","journal-title":"Am J Clin Dermatol"},{"issue":"Suppl. 1","key":"10.1111\/bjd.12706-BIB0003|bjd12706-cit-0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1468-3083.2011.04374.x","article-title":"European evidence-based (S3) guidelines for the treatment of acne","volume":"26","author":"Nast","year":"2012","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1111\/bjd.12706-BIB0004|bjd12706-cit-0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2230.2012.04335.x","article-title":"Baron SE; British Association of Dermatologists and Royal College of General Practitioners. Guidance on the diagnosis and clinical management of acne","volume":"37","author":"Archer","year":"2012","journal-title":"Clin Exp Dermatol"},{"issue":"Suppl. 1","key":"10.1111\/bjd.12706-BIB0005|bjd12706-cit-0005","first-page":"1","article-title":"Acne in India: guidelines for management - IAA consensus document","volume":"75","author":"Kubba","year":"2009","journal-title":"Indian J Dermatol Venereol Leprol"},{"issue":"Suppl. 2","key":"10.1111\/bjd.12706-BIB0006|bjd12706-cit-0006","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/j.1610-0387.2010.07466.supp.x","article-title":"S2k-guideline on treatment of acne","volume":"8","author":"Nast","year":"2010","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1111\/bjd.12706-BIB0007|bjd12706-cit-0007","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1177\/009286150804200608","article-title":"A noninferiority margin for acne lesion counts","volume":"42","author":"Gerlinger","year":"2008","journal-title":"Drug Inf J"},{"key":"10.1111\/bjd.12706-BIB0008|bjd12706-cit-0008","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1038\/jid.2013.78","article-title":"Which antipsoriatic drug has the fastest onset of action? Systematic review on the rapidity of the onset of action","volume":"133","author":"Nast","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.12706-BIB0009|bjd12706-cit-0009","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"62","author":"Moher","year":"2009","journal-title":"J Clin Epidemiol"},{"key":"10.1111\/bjd.12706-BIB0010|bjd12706-cit-0010","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1365-4362.1986.tb04534.x","article-title":"Comparing 2.5%, 5%, and 10% benzoyl peroxide on inflammatory acne vulgaris","volume":"25","author":"Mills","year":"1986","journal-title":"Int J Dermatol"},{"key":"10.1111\/bjd.12706-BIB0011|bjd12706-cit-0011","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1365-4362.1978.tb06072.x","article-title":"Comparative effectiveness of benzoyl peroxide and tretinoin in acne vulgaris","volume":"17","author":"Lyons","year":"1978","journal-title":"Int J Dermatol"},{"key":"10.1111\/bjd.12706-BIB0012|bjd12706-cit-0012","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1365-2230.1992.tb00196.x","article-title":"A double-blind evaluation of topical isotretinoin 0.05%, benzoyl peroxide gel 5% and placebo in patients with acne","volume":"17","author":"Hughes","year":"1992","journal-title":"Clin Exp Dermatol"},{"key":"10.1111\/bjd.12706-BIB0013|bjd12706-cit-0013","first-page":"145","article-title":"The efficacy and safety of adapalene gel 0.3% in the treatment of acne vulgaris: a randomized, multicenter, investigator-blinded, controlled comparison study versus adapalene gel 0.1% and vehicle","volume":"76","author":"Pariser","year":"2005","journal-title":"Cutis"},{"key":"10.1111\/bjd.12706-BIB0014|bjd12706-cit-0014","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1007\/BF00577761","article-title":"Liposomal tretinoin for uncomplicated acne vulgaris","volume":"72","author":"Schafer-Korting","year":"1994","journal-title":"Clin Investig"},{"key":"10.1111\/bjd.12706-BIB0015|bjd12706-cit-0015","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.clinthera.2007.06.021","article-title":"Tretinoin gel microspheres 0.04% versus 0.1% in adolescents and adults with mild to moderate acne vulgaris: a 12-week, multicenter, randomized, double-blind, parallel-group, phase IV trial","volume":"29","author":"Berger","year":"2007","journal-title":"Clin Ther"},{"key":"10.1111\/bjd.12706-BIB0016|bjd12706-cit-0016","first-page":"146","article-title":"A combined analysis of 2 randomized clinical studies of tretinoin gel 0.05% for the treatment of acne","volume":"83","author":"Webster","year":"2009","journal-title":"Cutis"},{"key":"10.1111\/bjd.12706-BIB0017|bjd12706-cit-0017","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1046\/j.1365-2133.2002.04873.x","article-title":"Topical adapalene gel 0.1% vs. isotretinoin gel 0.05% in the treatment of acne vulgaris: a randomized open-label clinical trial","volume":"147","author":"Ioannides","year":"2002","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.12706-BIB0018|bjd12706-cit-0018","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/09546630152607880","article-title":"A comparative trial of two retinoids commonly used in the treatment of acne vulgaris","volume":"12","author":"Nyirady","year":"2001","journal-title":"J Dermatolog Treat"},{"issue":"Suppl. 52","key":"10.1111\/bjd.12706-BIB0019|bjd12706-cit-0019","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1046\/j.1365-2133.1998.1390s2041.x","article-title":"Comparison of adapalene 0.1% solution and tretinoin 0.025% gel in the topical treatment of acne vulgaris","volume":"139","author":"Ellis","year":"1998","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.12706-BIB0020|bjd12706-cit-0020","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3109\/09546639709160514","article-title":"Efficacy and safety comparison of adapalene (CD271) gel and tretinoin gel in the topical treatment of acne vulgaris. A European multicentre trial","volume":"8","author":"Cunliffe","year":"1997","journal-title":"J Dermatolog Treat"},{"issue":"Suppl. 52","key":"10.1111\/bjd.12706-BIB0021|bjd12706-cit-0021","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1046\/j.1365-2133.1998.1390s2026.x","article-title":"Evaluation of clinical efficacy and safety of adapalene 0.1% gel versus tretinoin 0.025% gel in the treatment of acne vulgaris, with particular reference to the onset of action and impact on quality of life","volume":"139","author":"Grosshans","year":"1998","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.12706-BIB0022|bjd12706-cit-0022","first-page":"350","article-title":"Randomised, controlled trial of the efficacy and safety of adapalene gel 0.1% and tretinoin cream 0.05% in patients with acne vulgaris","volume":"12","author":"Cunliffe","year":"2002","journal-title":"Eur J Dermatol"},{"key":"10.1111\/bjd.12706-BIB0023|bjd12706-cit-0023","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1046\/j.1365-4362.1998.00254.x","article-title":"Topical isotretinoin vs. topical retinoic acid in the treatment of acne vulgaris","volume":"37","author":"Dominguez","year":"1998","journal-title":"Int J Dermatol"},{"key":"10.1111\/bjd.12706-BIB0024|bjd12706-cit-0024","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2165\/00128071-200102010-00006","article-title":"Comparison of the efficacy and safety of a combination topical gel formulation of benzoyl peroxide and clindamycin with benzoyl peroxide, clindamycin and vehicle gel in the treatments of acne vulgaris","volume":"2","author":"Leyden","year":"2001","journal-title":"Am J Clin Dermatol"},{"key":"10.1111\/bjd.12706-BIB0025|bjd12706-cit-0025","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0190-9622(97)70177-4","article-title":"Treatment of acne with a combination clindamycin\/benzoyl peroxide gel compared with clindamycin gel, benzoyl peroxide gel and vehicle gel: combined results of two double-blind investigations","volume":"37","author":"Lookingbill","year":"1997","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.12706-BIB0026|bjd12706-cit-0026","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/120347540100500109","article-title":"The efficacy and safety of a combination benzoyl peroxide\/clindamycin topical gel compared with benzoyl peroxide alone and a benzoyl peroxide\/erythromycin combination product","volume":"5","author":"Leyden","year":"2001","journal-title":"J Cutan Med Surg"},{"key":"10.1111\/bjd.12706-BIB0027|bjd12706-cit-0027","first-page":"534","article-title":"Solubilized benzoyl peroxide versus benzoyl peroxide\/clindamycin in the treatment of moderate acne","volume":"7","author":"Tanghetti","year":"2008","journal-title":"J Drugs Dermatol"},{"key":"10.1111\/bjd.12706-BIB0028|bjd12706-cit-0028","first-page":"714","article-title":"Effects of benzoyl peroxide 5% clindamycin combination gel versus adapalene 0.1% on quality of life in patients with mild to moderate acne vulgaris: a randomized single-blind study","volume":"11","author":"Guerra-Tapia","year":"2012","journal-title":"J Drugs Dermatol"},{"key":"10.1111\/bjd.12706-BIB0029|bjd12706-cit-0029","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1365-2133.2007.08308.x","article-title":"A randomized, single-blind comparison of topical clindamycin + benzoyl peroxide and adapalene in the treatment of mild to moderate facial acne vulgaris","volume":"158","author":"Langner","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.12706-BIB0030|bjd12706-cit-0030","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1468-3083.2008.02920.x","article-title":"Prospective, open-label, comparative study of clindamycin 1%\/benzoyl peroxide 5% gel with adapalene 0.1% gel in Asian acne patients: efficacy and tolerability","volume":"23","author":"Ko","year":"2009","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1111\/bjd.12706-BIB0031|bjd12706-cit-0031","first-page":"223","article-title":"Study of the efficacy, tolerability, and safety of 2 fixed-dose combination gels in the management of acne vulgaris","volume":"84","author":"Zouboulis","year":"2009","journal-title":"Cutis"},{"key":"10.1111\/bjd.12706-BIB0032|bjd12706-cit-0032","first-page":"265","article-title":"Comparison of 2 clindamycin 1%-benzoyl peroxide 5% topical gels used once daily in the management of acne vulgaris","volume":"83","author":"Dhawan","year":"2009","journal-title":"Cutis"},{"key":"10.1111\/bjd.12706-BIB0033|bjd12706-cit-0033","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2133.1984.tb04664.x","article-title":"Comparison of topical clindamycin phosphate, benzoyl peroxide, and a combination of the two for the treatment of acne vulgaris","volume":"110","author":"Tucker","year":"1984","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.12706-BIB0034|bjd12706-cit-0034","doi-asserted-by":"crossref","first-page":"434","DOI":"10.5414\/CP201694","article-title":"Low intrinsic drug activity and dominant vehicle (placebo) effect in the topical treatment of acne vulgaris","volume":"50","author":"Chiou","year":"2012","journal-title":"Int J Clin Pharmacol Ther"},{"key":"10.1111\/bjd.12706-BIB0035|bjd12706-cit-0035","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.jaad.2007.08.008","article-title":"Eligibility creep: a cause for placebo group improvement in controlled trials of psoriasis treatments","volume":"57","author":"Hick","year":"2007","journal-title":"J Am Acad Dermatol"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.12706","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/bjd.12706\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T14:07:32Z","timestamp":1676383652000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/170\/3\/557\/6614849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"URL":"https:\/\/doi.org\/10.1111\/bjd.12706","relation":{},"ISSN":["0007-0963"],"issn-type":[{"value":"0007-0963","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}