{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:36:27Z","timestamp":1781109387088,"version":"3.54.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":488,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Dermatol"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1111\/bjd.12816","type":"journal-article","created":{"date-parts":[[2014,1,4]],"date-time":"2014-01-04T11:58:38Z","timestamp":1388836718000},"page":"1056-1064","source":"Crossref","is-referenced-by-count":12,"title":["A truncating mutation in the laminin-332\u03b1 chain highlights the role of the LG45 proteolytic domain in regulating keratinocyte adhesion and migration"],"prefix":"10.1093","volume":"170","author":[{"given":"G.","family":"Di Zenzo","sequence":"first","affiliation":[{"name":"Laboratory of Molecular and Cell Biology; Istituto Dermopatico dell'Immacolata-IRCCS; via dei Monti di Creta 104 00167 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"El Hachem","sequence":"additional","affiliation":[{"name":"Dermatology Division; Ospedale Pediatrico Bambino Ges\u00f9-IRCCS; P.zza Sant'Onofrio 4 00165 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Diociaiuti","sequence":"additional","affiliation":[{"name":"Dermatology Division; Ospedale Pediatrico Bambino Ges\u00f9-IRCCS; P.zza Sant'Onofrio 4 00165 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Boldrini","sequence":"additional","affiliation":[{"name":"Department of Pathology; Ospedale Pediatrico Bambino Ges\u00f9-IRCCS; P.zza Sant'Onofrio 4 00165 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Calabresi","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cell Biology; Istituto Dermopatico dell'Immacolata-IRCCS; via dei Monti di Creta 104 00167 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Cianfarani","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cell Biology; Istituto Dermopatico dell'Immacolata-IRCCS; via dei Monti di Creta 104 00167 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Fortugno","sequence":"additional","affiliation":[{"name":"Dermatology Division; Ospedale Pediatrico Bambino Ges\u00f9-IRCCS; P.zza Sant'Onofrio 4 00165 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Piccinni","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cell Biology; Istituto Dermopatico dell'Immacolata-IRCCS; via dei Monti di Creta 104 00167 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Zambruno","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cell Biology; Istituto Dermopatico dell'Immacolata-IRCCS; via dei Monti di Creta 104 00167 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Castiglia","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cell Biology; Istituto Dermopatico dell'Immacolata-IRCCS; via dei Monti di Creta 104 00167 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,5,19]]},"reference":[{"key":"10.1111\/bjd.12816-BIB0001|bjd12816-cit-0001","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1600-0625.2008.00721.x","article-title":"Laminin-332 and -511 in skin","volume":"17","author":"Sugawara","year":"2008","journal-title":"Exp Dermatol"},{"key":"10.1111\/bjd.12816-BIB0002|bjd12816-cit-0002","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/nrc2089","article-title":"Tumour microenvironment: laminin 332 in squamous-cell carcinoma","volume":"7","author":"Marinkovich","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.1111\/bjd.12816-BIB0003|bjd12816-cit-0003","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4161\/cam.22418","article-title":"Laminin 332 in junctional epidermolysis bullosa","volume":"7","author":"Kiritsi","year":"2013","journal-title":"Cell Adhes Migr"},{"key":"10.1111\/bjd.12816-BIB0004|bjd12816-cit-0004","doi-asserted-by":"crossref","first-page":"23496","DOI":"10.1074\/jbc.270.40.23496","article-title":"The assembly of laminin-5 subunits","volume":"270","author":"Matsui","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1111\/bjd.12816-BIB0005|bjd12816-cit-0005","doi-asserted-by":"crossref","first-page":"122","DOI":"10.4161\/cam.23132","article-title":"Laminin 332 processing impacts cellular behavior","volume":"7","author":"Rousselle","year":"2013","journal-title":"Cell Adhes Migr"},{"key":"10.1111\/bjd.12816-BIB0006|bjd12816-cit-0006","doi-asserted-by":"crossref","first-page":"22728","DOI":"10.1074\/jbc.M002345200","article-title":"Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain","volume":"275","author":"Amano","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1111\/bjd.12816-BIB0007|bjd12816-cit-0007","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1083\/jcb.141.1.255","article-title":"Processing of laminin-5 and its functional consequences: role of plasmin and tissue-type plasminogen activator","volume":"141","author":"Goldfinger","year":"1998","journal-title":"J Cell Biol"},{"key":"10.1111\/bjd.12816-BIB0008|bjd12816-cit-0008","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1158\/0008-5472.CAN-07-6160","article-title":"Targeting a tumor-specific laminin domain critical for human carcinogenesis","volume":"68","author":"Tran","year":"2008","journal-title":"Cancer Res"},{"key":"10.1111\/bjd.12816-BIB0009|bjd12816-cit-0009","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.jaad.2010.07.006","article-title":"Risk of squamous cell carcinoma in junctional epidermolysis bullosa, non-Herlitz type: report of 7 cases and a review of the literature","volume":"65","author":"Yuen","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.12816-BIB0010|bjd12816-cit-0010","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/PAT.0b013e32835f515c","article-title":"Non-melanoma skin cancer: carcinogenesis and chemoprevention","volume":"45","author":"Chen","year":"2013","journal-title":"Pathology"},{"key":"10.1111\/bjd.12816-BIB0011|bjd12816-cit-0011","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.det.2009.10.006","article-title":"Herlitz junctional epidermolysis bullosa","volume":"28","author":"Laimer","year":"2010","journal-title":"Dermatol Clin"},{"key":"10.1111\/bjd.12816-BIB0012|bjd12816-cit-0012","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00439-004-1210-y","article-title":"Novel and recurrent mutations in the laminin-5 genes causing lethal junctional epidermolysis bullosa: molecular basis and clinical course of Herlitz disease","volume":"116","author":"M\u00fchle","year":"2005","journal-title":"Hum Genet"},{"key":"10.1111\/bjd.12816-BIB0013|bjd12816-cit-0013","first-page":"38","article-title":"Herlitz junctional epidermolysis bullosa: laminin-5 mutational profile and carrier frequency in the Italian population","volume":"158","author":"Castori","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.12816-BIB0014|bjd12816-cit-0014","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1111\/j.1365-2133.2011.10553.x","article-title":"Herlitz junctional epidermolysis bullosa: diagnostic features, mutational profile, incidence and population carrier frequency in the Netherlands","volume":"165","author":"Yuen","year":"2011","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.12816-BIB0015|bjd12816-cit-0015","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00439-001-0630-1","article-title":"Laminin 5 mutations in junctional epidermolysis bullosa: molecular basis of Herlitz vs. non-Herlitz phenotypes","volume":"110","author":"Nakano","year":"2002","journal-title":"Hum Genet"},{"key":"10.1111\/bjd.12816-BIB0016|bjd12816-cit-0016","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.0022-202X.2004.23302.x","article-title":"Laminin-5 mutational analysis in an Italian cohort of patients with junctional epidermolysis bullosa","volume":"123","author":"Posteraro","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.12816-BIB0017|bjd12816-cit-0017","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1093\/hmg\/10.21.2453","article-title":"Genetic bases of severe junctional epidermolysis bullosa presenting spontaneous amelioration with aging","volume":"10","author":"Gache","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1111\/bjd.12816-BIB0018|bjd12816-cit-0018","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1136\/jmg.2011.089615","article-title":"Efficiency of translation termination in humans is highly dependent upon nucleotides in the neighbourhood of a (premature) termination codon","volume":"48","author":"Pacho","year":"2011","journal-title":"J Med Genet"},{"key":"10.1111\/bjd.12816-BIB0019|bjd12816-cit-0019","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1046\/j.0022-202x.2001.01453.x","article-title":"Novel mutations in the LAMC2 gene in non-Herlitz junctional epidermolysis bullosa: effects on laminin-5 assembly, secretion, and deposition","volume":"117","author":"Castiglia","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.12816-BIB0020|bjd12816-cit-0020","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1093\/hmg\/ddg234","article-title":"An unusual N-terminal deletion of the laminin alpha3a isoform leads to the chronic granulation tissue disorder laryngo-onycho-cutaneous syndrome","volume":"12","author":"McLean","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1111\/bjd.12816-BIB0021|bjd12816-cit-0021","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2353\/ajpath.2006.051314","article-title":"Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential","volume":"169","author":"Cianfarani","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1111\/bjd.12816-BIB0022|bjd12816-cit-0022","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1001\/archderm.1990.01670270037006","article-title":"Multiple keratoacanthomas and junctional epidermolysis bullosa. A therapeutic conundrum","volume":"126","author":"Pellicano","year":"1990","journal-title":"Arch Dermatol"},{"key":"10.1111\/bjd.12816-BIB0023|bjd12816-cit-0023","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/ng0394-299","article-title":"Herlitz's junctional epidermolysis bullosa is linked to mutations in the gene (LAMC2) for the gamma 2 subunit of nicein\/kalinin (LAMININ-5)","volume":"6","author":"Aberdam","year":"1994","journal-title":"Nat Genet"},{"key":"10.1111\/bjd.12816-BIB0024|bjd12816-cit-0024","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1093\/hmg\/3.10.1909","article-title":"A novel homozygous nonsense mutation in the LAMC2 gene in patients with the Herlitz junctional epidermolysis bullosa","volume":"3","author":"Baudoin","year":"1994","journal-title":"Hum Mol Genet"},{"key":"10.1111\/bjd.12816-BIB0025|bjd12816-cit-0025","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1101\/gad.1566807","article-title":"Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function","volume":"21","author":"Isken","year":"2007","journal-title":"Genes Dev"},{"key":"10.1111\/bjd.12816-BIB0026|bjd12816-cit-0026","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1006\/excr.1997.3586","article-title":"Laminin-5 inhibits human keratinocyte migration","volume":"233","author":"O'Toole","year":"1997","journal-title":"Exp Cell Res"},{"key":"10.1111\/bjd.12816-BIB0027|bjd12816-cit-0027","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.1242\/jcs.01310","article-title":"Globular domains 4\/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5","volume":"117","author":"Sigle","year":"2004","journal-title":"J Cell Sci"},{"key":"10.1111\/bjd.12816-BIB0028|bjd12816-cit-0028","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0945-053X(00)00072-X","article-title":"Structure and function of laminin LG modules","volume":"19","author":"Timpl","year":"2000","journal-title":"Matrix Biol"},{"key":"10.1111\/bjd.12816-BIB0029|bjd12816-cit-0029","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S1097-2765(00)80388-3","article-title":"The crystal structure of a laminin G-like module reveals the molecular basis of alpha-dystroglycan binding to laminins, perlecan, and agrin","volume":"4","author":"Hohenester","year":"1999","journal-title":"Mol Cell"},{"key":"10.1111\/bjd.12816-BIB0030|bjd12816-cit-0030","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1093\/emboj\/19.7.1432","article-title":"Structure of the C-terminal laminin G-like domain pair of the laminin alpha2 chain harbouring binding sites for alpha-dystroglycan and heparin","volume":"19","author":"Tisi","year":"2000","journal-title":"EMBO J"},{"key":"10.1111\/bjd.12816-BIB0031|bjd12816-cit-0031","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nrm1052","article-title":"Quality control in the endoplasmic reticulum","volume":"4","author":"Ellgaard","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1111\/bjd.12816-BIB0032|bjd12816-cit-0032","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/74035","article-title":"Recognition of local glycoprotein misfolding by the ER folding sensor UDP-glucose:glycoprotein glucosyltransferase","volume":"7","author":"Ritter","year":"2000","journal-title":"Nat Struct Biol"},{"key":"10.1111\/bjd.12816-BIB0033|bjd12816-cit-0033","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0006-291X(03)01533-X","article-title":"A missense mutation (G1506E) in the adhesion G domain of laminin-5 causes mild junctional epidermolysis bullosa","volume":"309","author":"Scaturro","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/bjd.12816-BIB0034|bjd12816-cit-0034","doi-asserted-by":"crossref","first-page":"18828","DOI":"10.1074\/jbc.M100381200","article-title":"Reduced expression of the epithelial adhesion ligand laminin 5 in the skin causes intradermal tissue separation","volume":"276","author":"Spirito","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1111\/bjd.12816-BIB0035|bjd12816-cit-0035","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1086\/302672","article-title":"Digenic junctional epidermolysis bullosa: mutations in COL17A1 and LAMB3 genes","volume":"65","author":"Floeth","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1111\/bjd.12816-BIB0036|bjd12816-cit-0036","doi-asserted-by":"crossref","first-page":"28779","DOI":"10.1074\/jbc.M101420200","article-title":"A unique sequence of the laminin alpha 3\u00a0G domain binds to heparin and promotes cell adhesion through syndecan-2 and -4","volume":"276","author":"Utani","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1111\/bjd.12816-BIB0037|bjd12816-cit-0037","doi-asserted-by":"crossref","first-page":"12204","DOI":"10.1074\/jbc.M111.300061","article-title":"Cell surface proteoglycans syndecan-1 and -4 bind overlapping but distinct sites in laminin \u03b13 LG45 protein domain","volume":"287","author":"Carulli","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1111\/bjd.12816-BIB0038|bjd12816-cit-0038","article-title":"The syndecan binding sequence KKLRIKSKEK in laminin \u03b13 LG4 domain promotes epidermal repair","author":"Rousselle","year":"2013","journal-title":"Eur J Dermatol"},{"key":"10.1111\/bjd.12816-BIB0039|bjd12816-cit-0039","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.ajpath.2012.01.005","article-title":"Partial loss of epithelial phenotype in kindlin-1-deficient keratinocytes","volume":"180","author":"Qu","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1111\/bjd.12816-BIB0040|bjd12816-cit-0040","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1158\/0008-5472.CAN-11-2996","article-title":"Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa","volume":"72","author":"Ng","year":"2012","journal-title":"Cancer Res"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.12816","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/bjd.12816\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T14:08:21Z","timestamp":1676383701000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/170\/5\/1056\/6614829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"URL":"https:\/\/doi.org\/10.1111\/bjd.12816","relation":{},"ISSN":["0007-0963"],"issn-type":[{"value":"0007-0963","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}