{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T16:40:10Z","timestamp":1778949610563,"version":"3.51.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":237,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Dermatol"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1111\/bjd.13265","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T11:41:19Z","timestamp":1405424479000},"page":"494-503","source":"Crossref","is-referenced-by-count":10,"title":["Clindamycin phosphate 1\u00b72%-benzoyl peroxide 3\u00b70% fixed-dose combination gel has an effective and acceptable safety and tolerability profile for the treatment of acne vulgaris in Japanese patients: a phase III, multicentre, randomised, single-blinded, acti"],"prefix":"10.1093","volume":"172","author":[{"given":"M.","family":"Kawashima","sequence":"first","affiliation":[{"name":"Department of Dermatology; Tokyo Women's Medical University; Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Biomedical Data Science; Japan Development and Medical Affairs; GlaxoSmithKline K.K.; Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.B.","family":"Ali\u00f3 S\u00e1enz","sequence":"additional","affiliation":[{"name":"Medicines Development R&D; Stiefel, A GSK Company, Research Triangle Park; NC U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ono","sequence":"additional","affiliation":[{"name":"Business Innovation; GlaxoSmithKline K.K.; Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Yamada","sequence":"additional","affiliation":[{"name":"Medicines Development; Japan Development and Medical Affairs; GlaxoSmithKline K.K.; Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,1,7]]},"reference":[{"key":"10.1111\/bjd.13265-BIB0001|bjd13265-cit-0001","first-page":"1893","article-title":"[Guideline for the treatment of acne vulgaris]","volume":"118","author":"Hayashi","year":"2008","journal-title":"Jpn J Dermatol"},{"issue":"1 Suppl.","key":"10.1111\/bjd.13265-BIB0002|bjd13265-cit-0002","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1067\/mjd.2003.618","article-title":"Management of acne: a report from a Global Alliance to Improve Outcomes in Acne","volume":"49","author":"Gollnick","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.13265-BIB0003|bjd13265-cit-0003","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jdermsci.2007.09.012","article-title":"Adapalene gel 0.1% is effective and safe for Japanese patients with acne vulgaris: a randomized, multicenter, investigator-blinded, controlled study","volume":"49","author":"Kawashima","year":"2008","journal-title":"J Dermatol Sci"},{"key":"10.1111\/bjd.13265-BIB0004|bjd13265-cit-0004","first-page":"1714","article-title":"Acne vulgaris","volume":"2008","author":"Purdy","year":"2008","journal-title":"Clin Evid (Online)"},{"key":"10.1111\/bjd.13265-BIB0005|bjd13265-cit-0005","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1365-2133.2007.08308.x","article-title":"A randomized, single-blind comparison of topical clindamycin + benzoyl peroxide and adapalene in the treatment of mild to moderate facial acne vulgaris","volume":"158","author":"Langner","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.13265-BIB0006|bjd13265-cit-0006","first-page":"44","article-title":"A new, once-daily, optimized, fixed combination of clindamycin phosphate 1.2% and low-concentration benzoyl peroxide 2.5% gel for the treatment of moderate-to-severe acne","volume":"2","author":"Gold","year":"2009","journal-title":"J Clin Aesthet Dermatol"},{"key":"10.1111\/bjd.13265-BIB0007|bjd13265-cit-0007","unstructured":"Stiefel: a GSK company Summary product characteristics of Duac once daily 10\u00a0mg\/g\u00a0+\u00a050\u00a0mg\/g gel http:\/\/www.medicines.org.uk\/emc\/medicine\/13513\/SPC\/Duac+Once+Daily+10mg+g+%2b+50mg+g+Gel\/"},{"key":"10.1111\/bjd.13265-BIB0008|bjd13265-cit-0008","unstructured":"Stiefel: a GSK company Summary product characteristics of Duac once daily 10\u00a0mg\/g\u00a0+\u00a030 mg\/g gel http:\/\/www.medicines.org.uk\/emc\/medicine\/28007\/SPC\/Duac+Once+Daily+10+mg+g+%2b+30+mg+g+Gel\/"},{"key":"10.1111\/bjd.13265-BIB0009|bjd13265-cit-0009","first-page":"736","article-title":"Efficacy and tolerability of a fixed combination of clindamycin phosphate (1.2%) and low concentration benzoyl peroxide (2.5%) aqueous gel in moderate or severe acne subpopulations","volume":"8","author":"Webster","year":"2009","journal-title":"J Drugs Dermatol"},{"key":"10.1111\/bjd.13265-BIB0010|bjd13265-cit-0010","doi-asserted-by":"crossref","first-page":"813","DOI":"10.2165\/00128071-200304120-00002","article-title":"Is antibiotic resistance in cutaneous propionibacteria clinically relevant?: implications of resistance for acne patients and prescribers","volume":"4","author":"Eady","year":"2003","journal-title":"Am J Clin Dermatol"},{"key":"10.1111\/bjd.13265-BIB0011|bjd13265-cit-0011","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1348-0421.2008.00081.x","article-title":"Antimicrobial susceptibilities of Propionibacterium acnes isolated from patients with acne vulgaris","volume":"52","author":"Ishida","year":"2008","journal-title":"Microbiol Immunol"},{"key":"10.1111\/bjd.13265-BIB0012|bjd13265-cit-0012","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/j.1346-8138.2011.01423.x","article-title":"First report of high levels of clindamycin-resistant Propionibacterium acnes carrying erm(X) in Japanese patients with acne vulgaris","volume":"39","author":"Nakase","year":"2012","journal-title":"J Dermatol"},{"key":"10.1111\/bjd.13265-BIB0013|bjd13265-cit-0013","first-page":"161","article-title":"Susceptibility of Propionibacterium acnes isolated from patients with acne vulgaris to zinc ascorbate and antibiotics","volume":"4","author":"Iinuma","year":"2011","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"10.1111\/bjd.13265-BIB0014|bjd13265-cit-0014","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaad.2009.01.019","article-title":"New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group","volume":"60","author":"Thiboutot","year":"2009","journal-title":"J Am Acad Dermatol"},{"issue":"Suppl. 1","key":"10.1111\/bjd.13265-BIB0015|bjd13265-cit-0015","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/j.1468-3083.2011.04374.x","article-title":"European evidence-based (S3) guidelines for the treatment of acne","volume":"26","author":"Nast","year":"2012","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1111\/bjd.13265-BIB0016|bjd13265-cit-0016","first-page":"252","article-title":"A benzoyl peroxide-sulfur cream for acne vulgaris","volume":"93","author":"Pace","year":"1965","journal-title":"Can Med Assoc J"},{"key":"10.1111\/bjd.13265-BIB0017|bjd13265-cit-0017","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1159\/000093984","article-title":"\u2018Keratolytic\u2019 properties of benzoyl peroxide and retinoic acid resemble salicylic acid in man","volume":"19","author":"Waller","year":"2006","journal-title":"Skin Pharmacol Physiol"},{"key":"10.1111\/bjd.13265-BIB0018|bjd13265-cit-0018","first-page":"5","article-title":"Benzoyl peroxide: enhancing antibiotic efficacy in acne management","volume":"15","author":"Dutil","year":"2010","journal-title":"Skin Therapy Lett"},{"key":"10.1111\/bjd.13265-BIB0019|bjd13265-cit-0019","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1365-4362.1986.tb04534.x","article-title":"Kligman AM, Pochi P, Comite H. Comparing 2.5%, 5%, and 10% benzoyl peroxide on inflammatory acne vulgaris","volume":"25","author":"Mills","year":"1986","journal-title":"Int J Dermatol"},{"key":"10.1111\/bjd.13265-BIB0020|bjd13265-cit-0020","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1517\/14656560903277228","article-title":"Benzoyl peroxide: a review of its current use in the treatment of acne vulgaris","volume":"10","author":"Sagransky","year":"2009","journal-title":"Expert Opin Pharmacother"},{"key":"10.1111\/bjd.13265-BIB0021|bjd13265-cit-0021","first-page":"482","article-title":"Benzoyl peroxide development, pharmacology, formulation and clinical uses in topical fixed-combinations","volume":"9","author":"Harper","year":"2010","journal-title":"J Drugs Dermatol"},{"key":"10.1111\/bjd.13265-BIB0022|bjd13265-cit-0022","first-page":"1382","article-title":"Safety and efficacy of clindamycin phosphate 1.2%-benzoyl peroxide 3% fixed-dose combination gel for the treatment of acne vulgaris: a phase 3, multicenter, randomized, double-blind, active- and vehicle-controlled study","volume":"10","author":"Eichenfield","year":"2011","journal-title":"J Drugs Dermatol"},{"key":"10.1111\/bjd.13265-BIB0023|bjd13265-cit-0023","first-page":"281","article-title":"The effect of vehicle formulation on acne medication tolerability","volume":"82","author":"Draelos","year":"2008","journal-title":"Cutis"},{"key":"10.1111\/bjd.13265-BIB0024|bjd13265-cit-0024","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/cpdd.7","article-title":"Bioavailability of clindamycin from a new clindamycin phosphate 1.2%-benzoyl peroxide 3% combination gel","volume":"2","author":"Jones","year":"2013","journal-title":"Clin Pharmacol Drug Develop"},{"key":"10.1111\/bjd.13265-BIB0025|bjd13265-cit-0025","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/j.1365-2230.1991.tb01232.x","article-title":"The finger-tip unit - a new practical measure","volume":"16","author":"Long","year":"1991","journal-title":"Clin Exp Dermatol"},{"key":"10.1111\/bjd.13265-BIB0026|bjd13265-cit-0026","unstructured":"International Conference on Harmonisation Guidance E9: statistical principles for clinical trials http:\/\/www.ich.org\/fileadmin\/Public_Web_Site\/ICH_Products\/Guidelines\/Efficacy\/E9\/Step4\/E9_Guideline.pdf"},{"key":"10.1111\/bjd.13265-BIB0027|bjd13265-cit-0027","first-page":"673","article-title":"[Survey of the patients with acne at the dermatological clinics]","volume":"62","author":"Kawashima","year":"2008","journal-title":"Clin Dermatol"},{"key":"10.1111\/bjd.13265-BIB0028|bjd13265-cit-0028","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1468-3083.2008.02920.x","article-title":"Prospective, open-label, comparative study of clindamycin 1%\/benzoyl peroxide 5% gel with adapalene 0.1% gel in Asian acne patients: efficacy and tolerability","volume":"23","author":"Ko","year":"2009","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1111\/bjd.13265-BIB0029|bjd13265-cit-0029","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jdermsci.2010.06.003","article-title":"Structural and functional differences in barrier properties of African American, Caucasian and East Asian skin","volume":"59","author":"Muizzuddin","year":"2010","journal-title":"J Dermatol Sci"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.13265","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/bjd.13265\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T01:43:12Z","timestamp":1717033392000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/172\/2\/494\/6615735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,7]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"URL":"https:\/\/doi.org\/10.1111\/bjd.13265","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718499102.793503221","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.718499102.793498450","asserted-by":"object"}]},"ISSN":["0007-0963"],"issn-type":[{"value":"0007-0963","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1,7]]}}}