{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:49:53Z","timestamp":1789386593269,"version":"build-2803163510"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":292,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["KR 905\/6-2, KR 905\/7-1 and SCHN 569\/4-1"],"award-info":[{"award-number":["KR 905\/6-2, KR 905\/7-1 and SCHN 569\/4-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Dermatol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1111\/bjd.13308","type":"journal-article","created":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T05:04:40Z","timestamp":1406783080000},"page":"1347-1357","source":"Crossref","is-referenced-by-count":9,"title":["A mouse organotypic tissue culture model for autosomal recessive congenital ichthyosis"],"prefix":"10.1093","volume":"171","author":[{"given":"S.","family":"Rosenberger","sequence":"first","affiliation":[{"name":"Genome Modifications and Carcinogenesis; Deutsches Krebsforschungszentrum; Im Neuenheimer Feld 280 D-69120 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dick","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; University of Erlangen-N\u00fcrnberg; D-91054 Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Latzko","sequence":"additional","affiliation":[{"name":"Genome Modifications and Carcinogenesis; Deutsches Krebsforschungszentrum; Im Neuenheimer Feld 280 D-69120 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Hausser","sequence":"additional","affiliation":[{"name":"Institute of Pathology; University Hospital Heidelberg and Electron Microscopy Core Facility; Heidelberg University; D-69115 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-J.","family":"Stark","sequence":"additional","affiliation":[{"name":"Genetics of Skin Carcinogenesis; Deutsches Krebsforschungszentrum; Im Neuenheimer Feld 280 D-69120 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rauh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; University of Erlangen-N\u00fcrnberg; D-91054 Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; University of Erlangen-N\u00fcrnberg; D-91054 Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Krieg","sequence":"additional","affiliation":[{"name":"Genome Modifications and Carcinogenesis; Deutsches Krebsforschungszentrum; Im Neuenheimer Feld 280 D-69120 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,11,13]]},"reference":[{"key":"10.1111\/bjd.13308-BIB0001|bjd13308-cit-0001","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbrc.2006.07.035","article-title":"Gene silencing in a human organotypic skin model","volume":"348","author":"Mildner","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/bjd.13308-BIB0002|bjd13308-cit-0002","doi-asserted-by":"crossref","first-page":"970","DOI":"10.2353\/ajpath.2009.080860","article-title":"Premature terminal differentiation and a reduction in specific proteases associated with loss of ABCA12 in Harlequin ichthyosis","volume":"174","author":"Thomas","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1111\/bjd.13308-BIB0003|bjd13308-cit-0003","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1093\/hmg\/ddq145","article-title":"Interleukin-1 alpha blockade prevents hyperkeratosis in an in vitro model of lamellar ichthyosis","volume":"19","author":"O'Shaughnessy","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1111\/bjd.13308-BIB0004|bjd13308-cit-0004","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1038\/jid.2010.115","article-title":"Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model","volume":"130","author":"Mildner","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.13308-BIB0005|bjd13308-cit-0005","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1755-148X.2010.00786.x","article-title":"Artificial skin in perspective: concepts and applications","volume":"24","author":"Brohem","year":"2011","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1111\/bjd.13308-BIB0006|bjd13308-cit-0006","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1038\/jid.2011.126","article-title":"Full-thickness human skin models for congenital ichthyosis and related keratinization disorders","volume":"131","author":"Eckl","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.13308-BIB0007|bjd13308-cit-0007","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2353\/ajpath.2008.080173","article-title":"Development and validation of human psoriatic skin equivalents","volume":"173","author":"Tjabringa","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1111\/bjd.13308-BIB0008|bjd13308-cit-0008","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1517\/17425255.2013.816284","article-title":"Reconstructed skin models as emerging tools for drug absorption studies","volume":"9","author":"K\u00fcchler","year":"2013","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1111\/bjd.13308-BIB0009|bjd13308-cit-0009","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1159\/000336268","article-title":"Organotypic modeling of human keratinocyte response to peroxisome proliferators","volume":"196","author":"Zhang","year":"2012","journal-title":"Cells Tissues Organs"},{"key":"10.1111\/bjd.13308-BIB0010|bjd13308-cit-0010","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/all.12051","article-title":"Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model","volume":"68","author":"Gschwandtner","year":"2013","journal-title":"Allergy"},{"key":"10.1111\/bjd.13308-BIB0011|bjd13308-cit-0011","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/jid.2013.402","article-title":"Filaggrin deficiency leads to impaired lipid profile and altered acidification pathways in a 3D skin construct","volume":"134","author":"V\u00e1vrov\u00e1","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.13308-BIB0012|bjd13308-cit-0012","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jaad.2009.11.020","article-title":"Revised nomenclature and classification of inherited ichthyoses: results of the First Ichthyosis Consensus Conference in Soreze 2009","volume":"63","author":"Oji","year":"2010","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.13308-BIB0013|bjd13308-cit-0013","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/jid.2009.57","article-title":"Autosomal recessive congenital ichthyosis","volume":"129","author":"Fischer","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.13308-BIB0014|bjd13308-cit-0014","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1038\/jid.2008.409","article-title":"Molecular analysis of 250 patients with autosomal recessive congenital ichthyosis: evidence for mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B","volume":"129","author":"Eckl","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.13308-BIB0015|bjd13308-cit-0015","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/humu.20236","article-title":"Mutation spectrum and functional analysis of epidermis-type lipoxygenases in patients with autosomal recessive congenital ichthyosis","volume":"26","author":"Eckl","year":"2005","journal-title":"Hum Mutat"},{"key":"10.1111\/bjd.13308-BIB0016|bjd13308-cit-0016","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/hmg\/11.1.107","article-title":"Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1","volume":"11","author":"Jobard","year":"2002","journal-title":"Hum Mol Genet"},{"key":"10.1111\/bjd.13308-BIB0017|bjd13308-cit-0017","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/sj.jid.5700640","article-title":"Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13","volume":"127","author":"Lesueur","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.13308-BIB0018|bjd13308-cit-0018","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/978-1-4615-0193-0_26","article-title":"Epidermis-type lipoxygenases","volume":"507","author":"Krieg","year":"2002","journal-title":"Adv Exp Med Biol"},{"key":"10.1111\/bjd.13308-BIB0019|bjd13308-cit-0019","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.bbalip.2013.08.005","article-title":"The role of lipoxygenases in epidermis","volume":"1841","author":"Krieg","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1111\/bjd.13308-BIB0020|bjd13308-cit-0020","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1006\/geno.1999.5816","article-title":"cDNA cloning, genomic structure, and chromosomal localization of a novel murine epidermis-type lipoxygenase","volume":"58","author":"Kinzig","year":"1999","journal-title":"Genomics"},{"key":"10.1111\/bjd.13308-BIB0021|bjd13308-cit-0021","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0014-5793(99)00196-9","article-title":"Murine 12(R)-lipoxygenase: functional expression, genomic structure and chromosomal localization","volume":"446","author":"Krieg","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1111\/bjd.13308-BIB0022|bjd13308-cit-0022","doi-asserted-by":"crossref","first-page":"9162","DOI":"10.1073\/pnas.1633612100","article-title":"The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase","volume":"100","author":"Yu","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/bjd.13308-BIB0023|bjd13308-cit-0023","doi-asserted-by":"crossref","first-page":"39866","DOI":"10.1074\/jbc.M110.155374","article-title":"Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids","volume":"285","author":"Zheng","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1111\/bjd.13308-BIB0024|bjd13308-cit-0024","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1038\/jid.2008.410","article-title":"Development of an ichthyosiform phenotype in Alox12b-deficient mouse skin transplants","volume":"129","author":"Juanes","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.13308-BIB0025|bjd13308-cit-0025","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1083\/jcb.200612116","article-title":"12R-lipoxygenase deficiency disrupts epidermal barrier function","volume":"177","author":"Epp","year":"2007","journal-title":"J Cell Biol"},{"key":"10.1111\/bjd.13308-BIB0026|bjd13308-cit-0026","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/jid.2012.250","article-title":"Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation","volume":"133","author":"Krieg","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.13308-BIB0027|bjd13308-cit-0027","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.bbalip.2013.08.020","article-title":"The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier","volume":"1841","author":"Mu\u00f1oz-Garcia","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1111\/bjd.13308-BIB0028|bjd13308-cit-0028","doi-asserted-by":"crossref","first-page":"24046","DOI":"10.1074\/jbc.M111.251496","article-title":"Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope","volume":"286","author":"Zheng","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1111\/bjd.13308-BIB0029|bjd13308-cit-0029","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nprot.2008.50","article-title":"Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice","volume":"3","author":"Lichti","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1111\/bjd.13308-BIB0030|bjd13308-cit-0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-662-03011-0_1","volume-title":"Cell Culture in Pharmaceutical Research","author":"Fusenig","year":"1994"},{"key":"10.1111\/bjd.13308-BIB0031|bjd13308-cit-0031","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-5945-11-9","article-title":"Establishment of a murine epidermal cell line suitable for in vitro and in vivo skin modelling","volume":"11","author":"Segrelles","year":"2011","journal-title":"BMC Dermatol"},{"key":"10.1111\/bjd.13308-BIB0032|bjd13308-cit-0032","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1046\/j.1523-1747.1999.00573.x","article-title":"Organotypic keratinocyte\u00a0cocultures in defined medium with regular epidermal morphogenesis and differentiation","volume":"112","author":"Stark","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.13308-BIB0033|bjd13308-cit-0033","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.ejcb.2006.12.005","article-title":"Effects of fibroblasts and microenvironment on epidermal regeneration and tissue function in long-term skin equivalents","volume":"86","author":"Boehnke","year":"2007","journal-title":"Eur J Cell Biol"},{"key":"10.1111\/bjd.13308-BIB0034|bjd13308-cit-0034","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1046\/j.1523-1747.1999.00535.x","article-title":"Keratin 15 expression in stratified epithelia: down regulation in activated keratinocytes","volume":"112","author":"Waseem","year":"1999","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1111\/bjd.13308-BIB0035|bjd13308-cit-0035","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1365-2133.2010.09745.x","article-title":"Partially disturbed lamellar granule secretion in mild congenital ichthyosiform erythroderma with ALOX12B mutations","volume":"163","author":"Akiyama","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.13308-BIB0036|bjd13308-cit-0036","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.chemphyslip.2010.02.003","article-title":"Identification of\u00a0oxylipins with antifungal activity by LC-MS\/MS from the supernatant of Pseudomonas 42A2","volume":"163","author":"Martin-Arjol","year":"2010","journal-title":"Chem Phys Lipids"},{"key":"10.1111\/bjd.13308-BIB0037|bjd13308-cit-0037","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1109\/JSEN.2009.2035736","article-title":"Endogenous levels of five fatty acid metabolites in exhaled breath condensate to monitor asthma by high-performance liquid chromatography: electrospray tandem mass spectrometry","volume":"10","author":"Nording","year":"2010","journal-title":"IEEE Sens J"},{"key":"10.1111\/bjd.13308-BIB0038|bjd13308-cit-0038","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s00216-012-6226-x","article-title":"Quantitative profiling of oxylipins through comprehensive LC-MS\/MS analysis: application in cardiac surgery","volume":"404","author":"Strassburg","year":"2012","journal-title":"Anal Bioanal Chem"},{"issue":"Suppl. 1","key":"10.1111\/bjd.13308-BIB0039|bjd13308-cit-0039","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0169-409X(02)00121-7","article-title":"New insights into skin structure: scratching the surface","volume":"54","author":"Menon","year":"2002","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1111\/bjd.13308-BIB0040|bjd13308-cit-0040","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/exd.12366","article-title":"Increased cutaneous absorption reflects impaired barrier function of reconstructed skin models mimicking keratinisation disorders","volume":"23","author":"Eckl","year":"2014","journal-title":"Exp Dermatol"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.13308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/bjd.13308\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T14:11:37Z","timestamp":1676383897000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/171\/6\/1347\/6616221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,13]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"URL":"https:\/\/doi.org\/10.1111\/bjd.13308","relation":{},"ISSN":["0007-0963"],"issn-type":[{"value":"0007-0963","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11,13]]}}}