{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:47:59Z","timestamp":1791946079008,"version":"4.3.4"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":186,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/PR13415\/BRB\/10\/758\/2009"],"award-info":[{"award-number":["BT\/PR13415\/BRB\/10\/758\/2009"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Dermatol"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1111\/bjd.13511","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T04:04:45Z","timestamp":1415246685000},"page":"940-950","source":"Crossref","is-referenced-by-count":74,"title":["Alteration in regulatory T cells and programmed cell death 1-expressing regulatory T cells in active generalized vitiligo and their clinical correlation"],"prefix":"10.1093","volume":"172","author":[{"given":"M.K.","family":"Tembhre","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology; All India Institute of Medical Sciences (AIIMS); Ansari Nagar 110029 New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.S.","family":"Parihar","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology; All India Institute of Medical Sciences (AIIMS); Ansari Nagar 110029 New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology; All India Institute of Medical Sciences (AIIMS); Ansari Nagar 110029 New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry; All India Institute of Medical Sciences (AIIMS); Ansari Nagar New Delhi 110029 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Department of Biochemistry; All India Institute of Medical Sciences (AIIMS); Ansari Nagar New Delhi 110029 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology; All India Institute of Medical Sciences (AIIMS); Ansari Nagar 110029 New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,2,27]]},"reference":[{"key":"10.1111\/bjd.13511-BIB0001|bjd13511-cit-0001","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1600-0749.2004.00130.x","article-title":"On the etiology of contact\/occupational vitiligo","volume":"17","author":"Boissy","year":"2004","journal-title":"Pigment Cell Res"},{"key":"10.1111\/bjd.13511-BIB0002|bjd13511-cit-0002","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1034\/j.1600-0749.2000.130106.x","article-title":"Higher plasma catecholamine and metabolite levels in the early phase of non-segmental vitiligo","volume":"13","author":"Cucchi","year":"2000","journal-title":"Pigment Cell Res"},{"key":"10.1111\/bjd.13511-BIB0003|bjd13511-cit-0003","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/jid.1959.49","article-title":"Vitiligo","volume":"32","author":"Lerner","year":"1959","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.13511-BIB0004|bjd13511-cit-0004","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1600-0749.2005.00244.x","article-title":"Melanocyte-specific, cytotoxic T cell responses in vitiligo: the effective variant of melanoma immunity?","volume":"18","author":"Garbelli","year":"2005","journal-title":"Pigment Cell Res"},{"key":"10.1111\/bjd.13511-BIB0005|bjd13511-cit-0005","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1034\/j.1600-0749.2003.00023.x","article-title":"Evidence for an autoimmune pathogenesis of vitiligo","volume":"16","author":"Ongenae","year":"2003","journal-title":"Pigment Cell Res"},{"key":"10.1111\/bjd.13511-BIB0006|bjd13511-cit-0006","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1600-0625.2007.00666_1.x","article-title":"Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else?","volume":"17","author":"Schallreuter","year":"2008","journal-title":"Exp Dermatol"},{"key":"10.1111\/bjd.13511-BIB0007|bjd13511-cit-0007","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1038\/jid.2009.32","article-title":"Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients","volume":"129","author":"Boorn","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.13511-BIB0008|bjd13511-cit-0008","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.autrev.2006.09.010","article-title":"Autoantibody responses to melanocytes in the depigmenting skin disease vitiligo","volume":"6","author":"Kemp","year":"2007","journal-title":"Autoimmun Rev"},{"key":"10.1111\/bjd.13511-BIB0009|bjd13511-cit-0009","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3892\/mmr.2012.1117","article-title":"CD8+ T cells from vitiligo perilesional margins induce autologous melanocyte apoptosis","volume":"7","author":"Wu","year":"2013","journal-title":"Mol Med Rep"},{"key":"10.1111\/bjd.13511-BIB0010|bjd13511-cit-0010","doi-asserted-by":"crossref","first-page":"e37513","DOI":"10.1371\/journal.pone.0037513","article-title":"Global activation of CD8+ cytotoxic T lymphocytes correlates with an impairment in regulatory T cells in patients with generalized vitiligo","volume":"7","author":"Lili","year":"2012","journal-title":"PLoS One"},{"key":"10.1111\/bjd.13511-BIB0011|bjd13511-cit-0011","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0092-8674(00)80856-9","article-title":"Regulatory T cells: key controllers of immunologic self-tolerance","volume":"101","author":"Sakaguchi","year":"2000","journal-title":"Cell"},{"key":"10.1111\/bjd.13511-BIB0012|bjd13511-cit-0012","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ni1178","article-title":"Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self","volume":"6","author":"Sakaguchi","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1111\/bjd.13511-BIB0013|bjd13511-cit-0013","doi-asserted-by":"crossref","first-page":"89195","DOI":"10.1155\/2007\/89195","article-title":"Regulatory T cells and human disease","volume":"2007","author":"Cools","year":"2007","journal-title":"Clin Dev Immunol"},{"key":"10.1111\/bjd.13511-BIB0014|bjd13511-cit-0014","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"10.1111\/bjd.13511-BIB0015|bjd13511-cit-0015","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/ni1179","article-title":"A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3","volume":"6","author":"Fontenot","year":"2005","journal-title":"Nat Immunol"},{"issue":"Suppl.","key":"10.1111\/bjd.13511-BIB0016|bjd13511-cit-0016","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jaut.2005.04.008","article-title":"IPEX and FOXP3: clinical and research perspectives","volume":"25","author":"Wildin","year":"2005","journal-title":"J Autoimmun"},{"key":"10.1111\/bjd.13511-BIB0017|bjd13511-cit-0017","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1136\/jmg.39.8.537","article-title":"Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome","volume":"39","author":"Wildin","year":"2002","journal-title":"J Med Genet"},{"key":"10.1111\/bjd.13511-BIB0018|bjd13511-cit-0018","doi-asserted-by":"crossref","first-page":"10398","DOI":"10.1073\/pnas.0403342101","article-title":"Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease","volume":"101","author":"Paust","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/bjd.13511-BIB0019|bjd13511-cit-0019","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/ni1003","article-title":"Modulation of tryptophan catabolism by regulatory T cells","volume":"4","author":"Fallarino","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1111\/bjd.13511-BIB0020|bjd13511-cit-0020","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1365-2567.2006.02321.x","article-title":"Mechanisms of immune suppression by interleukin-10 and transforming growth factor-\u03b2: the role of T regulatory cells","volume":"117","author":"Taylor","year":"2006","journal-title":"Immunology"},{"key":"10.1111\/bjd.13511-BIB0021|bjd13511-cit-0021","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000067596","article-title":"The role of IL-10 and TGF-\u03b2 in the differentiation and effector function of T regulatory cells","volume":"129","author":"Levings","year":"2002","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1111\/bjd.13511-BIB0022|bjd13511-cit-0022","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1172\/JCI40926","article-title":"Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice","volume":"120","author":"Tomura","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1111\/bjd.13511-BIB0023|bjd13511-cit-0023","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.clim.2007.11.008","article-title":"Differential expression of CCR7 defines two distinct subsets of human memory CD4+CD25+ Tregs","volume":"126","author":"Tosello","year":"2008","journal-title":"Clin Immunol"},{"key":"10.1111\/bjd.13511-BIB0024|bjd13511-cit-0024","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.4049\/jimmunol.177.7.4488","article-title":"The majority of human peripheral blood CD4+ CD25high Foxp3+ regulatory T cells bear functional skin-homing receptors","volume":"177","author":"Hirahara","year":"2006","journal-title":"J Immunol"},{"key":"10.1111\/bjd.13511-BIB0025|bjd13511-cit-0025","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1084\/jem.20061405","article-title":"CCR7 is required for the in vivo function of CD4CD25 regulatory T cells","volume":"204","author":"Schneider","year":"2007","journal-title":"J Exp Med"},{"key":"10.1111\/bjd.13511-BIB0026|bjd13511-cit-0026","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1084\/jem.20070081","article-title":"Altering the distribution of Foxp3 regulatory T cells results in tissue-specific inflammatory disease","volume":"204","author":"Sather","year":"2007","journal-title":"J Exp Med"},{"key":"10.1111\/bjd.13511-BIB0027|bjd13511-cit-0027","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/pcmr.12105","article-title":"Decreased regulatory T-cells and CD4+\/CD8+ ratio correlate with disease onset and progression in patients with generalized vitiligo","volume":"26","author":"Dwivedi","year":"2013","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1111\/bjd.13511-BIB0028|bjd13511-cit-0028","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1755-148X.2011.00920.x","article-title":"Functional defects of peripheral regulatory T lymphocytes in patients with progressive vitiligo","volume":"25","author":"Ben Ahmed","year":"2012","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1111\/bjd.13511-BIB0029|bjd13511-cit-0029","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1755-148X.2010.00688.x","article-title":"Reduced skin homing by functional Treg in vitiligo","volume":"23","author":"Klarquist","year":"2010","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1111\/bjd.13511-BIB0030|bjd13511-cit-0030","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/intimm\/8.5.765","article-title":"Expression of the PD1 antigen on the surface of stimulated mouse T and B lymphocytes","volume":"8","author":"Agata","year":"1996","journal-title":"Int Immunol"},{"key":"10.1111\/bjd.13511-BIB0031|bjd13511-cit-0031","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1002\/j.1460-2075.1992.tb05481.x","article-title":"Induced expression of PD1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death","volume":"11","author":"Ishida","year":"1992","journal-title":"EMBO J"},{"key":"10.1111\/bjd.13511-BIB0032|bjd13511-cit-0032","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/ni1443","article-title":"The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection","volume":"8","author":"Sharpe","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1111\/bjd.13511-BIB0033|bjd13511-cit-0033","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.immunol.26.021607.090331","article-title":"PD1 and its ligands in tolerance and immunity","volume":"26","author":"Keir","year":"2008","journal-title":"Annu Rev Immunol"},{"key":"10.1111\/bjd.13511-BIB0034|bjd13511-cit-0034","doi-asserted-by":"crossref","first-page":"10468","DOI":"10.1073\/pnas.1201131109","article-title":"Regulatory T cells use programmed death 1 ligands to directly suppress autoreactive B cells in vivo","volume":"109","author":"Gotot","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/bjd.13511-BIB0035|bjd13511-cit-0035","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1084\/jem.192.7.1027","article-title":"Engagement of the PD1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation","volume":"192","author":"Freeman","year":"2000","journal-title":"J Exp Med"},{"key":"10.1111\/bjd.13511-BIB0036|bjd13511-cit-0036","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/85330","article-title":"PD-L2 is a second ligand for PD1 and inhibits T cell activation","volume":"2","author":"Latchman","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1111\/bjd.13511-BIB0037|bjd13511-cit-0037","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1600-065X.2010.00923.x","article-title":"The PD1 pathway in tolerance and autoimmunity","volume":"236","author":"Francisco","year":"2010","journal-title":"Immunol Rev"},{"key":"10.1111\/bjd.13511-BIB0038|bjd13511-cit-0038","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0952-7915(02)00341-2","article-title":"Negative co-receptors on lymphocytes","volume":"14","author":"Greenwald","year":"2002","journal-title":"Curr Opin Immunol"},{"key":"10.1111\/bjd.13511-BIB0039|bjd13511-cit-0039","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/0470871628.ch6","article-title":"CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo","volume":"252","author":"Baecher-Allan","year":"2003","journal-title":"Novartis Found Symp"},{"key":"10.1111\/bjd.13511-BIB0040|bjd13511-cit-0040","first-page":"723","article-title":"Cell interactions in the induction of tolerance: the role of thymic lymphocytes","volume":"18","author":"Gershon","year":"1970","journal-title":"Immunology"},{"key":"10.1111\/bjd.13511-BIB0041|bjd13511-cit-0041","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jaad.2008.09.048","article-title":"The role of helper and regulatory T cells in the pathogenesis of vitiligo","volume":"60","author":"Basak","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.13511-BIB0042|bjd13511-cit-0042","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00403-011-1154-8","article-title":"Levels of TGF-\u03b21 in serum and culture supernatants of CD4+CD25+ T cells from patients with non-segmental vitiligo","volume":"303","author":"Tu","year":"2011","journal-title":"Arch Dermatol Res"},{"key":"10.1111\/bjd.13511-BIB0043|bjd13511-cit-0043","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/ijd.12160","article-title":"Assessment of tissue FoxP3+, CD4+ and CD8+ T-cells in active and stable nonsegmental vitiligo","volume":"53","author":"Abdallah","year":"2014","journal-title":"Int J Dermatol"},{"key":"10.1111\/bjd.13511-BIB0044|bjd13511-cit-0044","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/j.1755-148X.2012.01019.x","article-title":"Systemic analyses of immunophenotypes of peripheral T cells in non-segmental vitiligo: implication of defective natural killer T cells","volume":"25","author":"Zhou","year":"2012","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1111\/bjd.13511-BIB0045|bjd13511-cit-0045","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/jid.2013.540","article-title":"A quantitative increase in regulatory T cells controls development of vitiligo","volume":"134","author":"Chatterjee","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.13511-BIB0046|bjd13511-cit-0046","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cca.2013.05.005","article-title":"T helper and regulatory T cell cytokine profile in active, stable and narrow band ultraviolet B treated generalized vitiligo","volume":"424","author":"Tembhre","year":"2013","journal-title":"Clin Chim Acta"},{"key":"10.1111\/bjd.13511-BIB0047|bjd13511-cit-0047","doi-asserted-by":"crossref","first-page":"840","DOI":"10.4049\/jimmunol.177.2.840","article-title":"Regulation of trafficking receptor expression in human forkhead box P3 regulatory T cells","volume":"177","author":"Lim","year":"2006","journal-title":"J Immunol"},{"key":"10.1111\/bjd.13511-BIB0048|bjd13511-cit-0048","first-page":"567","article-title":"CD4+CD25hi regulatory T cells in healthy males and females mediate gender difference in the prevalence of autoimmune diseases","volume":"58","author":"Afshan","year":"2012","journal-title":"Clin Lab"},{"key":"10.1111\/bjd.13511-BIB0049|bjd13511-cit-0049","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.coi.2007.04.012","article-title":"PD1 and its ligands in T-cell immunity","volume":"19","author":"Keir","year":"2007","journal-title":"Curr Opin Immunol"},{"key":"10.1111\/bjd.13511-BIB0050|bjd13511-cit-0050","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.4049\/jimmunol.176.5.2808","article-title":"Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells","volume":"176","author":"Raimondi","year":"2006","journal-title":"J Immunol"},{"key":"10.1111\/bjd.13511-BIB0051|bjd13511-cit-0051","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1084\/jem.20062105","article-title":"Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis","volume":"204","author":"Scott-Browne","year":"2007","journal-title":"J Exp Med"},{"key":"10.1111\/bjd.13511-BIB0052|bjd13511-cit-0052","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1172\/JCI31911","article-title":"Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase","volume":"117","author":"Sharma","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1111\/bjd.13511-BIB0053|bjd13511-cit-0053","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1172\/JCI36604","article-title":"PD-L1 negatively regulates CD4+ CD25+ Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV","volume":"119","author":"Franceschini","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1111\/bjd.13511-BIB0054|bjd13511-cit-0054","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/intimm\/dxm057","article-title":"PD1 and PD1 ligands: from discovery to clinical application","volume":"19","author":"Okazaki","year":"2007","journal-title":"Int Immunol"},{"key":"10.1111\/bjd.13511-BIB0055|bjd13511-cit-0055","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/ni.2762","article-title":"A rheostat for immune responses: the unique properties of PD1 and their advantages for clinical application","volume":"14","author":"Okazaki","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1111\/bjd.13511-BIB0056|bjd13511-cit-0056","first-page":"17","article-title":"Role of PD1 in regulating T-cell immunity","volume":"350","author":"Jin","year":"2011","journal-title":"Curr Top Microbiol Immunol"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.13511","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/bjd.13511\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T14:12:51Z","timestamp":1676383971000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/172\/4\/940\/6615944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,27]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"URL":"https:\/\/doi.org\/10.1111\/bjd.13511","relation":{},"ISSN":["0007-0963"],"issn-type":[{"value":"0007-0963","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2,27]]}}}