{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:35:47Z","timestamp":1791372947716,"version":"4.3.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T00:00:00Z","timestamp":1430352000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T00:00:00Z","timestamp":1430352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Dermatol"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1111\/bjd.13598","type":"journal-article","created":{"date-parts":[[2014,12,13]],"date-time":"2014-12-13T08:43:16Z","timestamp":1418460196000},"page":"1601-1612","source":"Crossref","is-referenced-by-count":91,"title":["Long-term observational study of afamelanotide in 115 patients with erythropoietic protoporphyria"],"prefix":"10.1093","volume":"172","author":[{"given":"G.","family":"Biolcati","sequence":"first","affiliation":[{"name":"Porphyria Centre; San Gallicano Dermatological Institute; IRCCS - IFO; Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Marchesini","sequence":"additional","affiliation":[{"name":"FarmED Service; Pharmacovigilance - Pharmacy - IFO; Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Sorge","sequence":"additional","affiliation":[{"name":"Porphyria Centre; San Gallicano Dermatological Institute; IRCCS - IFO; Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Porphyria Centre; San Gallicano Dermatological Institute; IRCCS - IFO; Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Schneider-Yin","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine; Municipal Hospital Triemli; Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.I.","family":"Minder","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine; Municipal Hospital Triemli; Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,4,30]]},"reference":[{"key":"10.1111\/bjd.13598-BIB0001|bjd13598-cit-0001","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/S0140-6736(61)92427-8","article-title":"Erythropoietic protoporphyria. A new porphyria syndrome with solar urticaria due to protoporphyrinaemia","volume":"2","author":"Magnus","year":"1961","journal-title":"Lancet"},{"key":"10.1111\/bjd.13598-BIB0002|bjd13598-cit-0002","first-page":"2991","volume-title":"The Metabolic and Molecular Basis of Inherited Disease","author":"Anderson","year":"2001","edition":"8"},{"key":"10.1111\/bjd.13598-BIB0003|bjd13598-cit-0003","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1034\/j.1600-0781.2002.00708.x","article-title":"Erythropoietic protoporphyria (EPP) at 40. Where are we now?","volume":"18","author":"Sarkany","year":"2002","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"10.1111\/bjd.13598-BIB0004|bjd13598-cit-0004","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1750-1172-4-19","article-title":"Erythropoietic protoporphyria","volume":"4","author":"Lecha","year":"2009","journal-title":"Orphanet J Rare Dis"},{"key":"10.1111\/bjd.13598-BIB0005|bjd13598-cit-0005","first-page":"299","volume-title":"Handbook of Porphyrin Science","author":"Schneider-Yin","year":"2013"},{"key":"10.1111\/bjd.13598-BIB0006|bjd13598-cit-0006","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1365-2133.2006.07472.x","article-title":"Erythropoietic protoporphyria in the U.K.: clinical features and effect on quality of life","volume":"155","author":"Holme","year":"2006","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.13598-BIB0007|bjd13598-cit-0007","first-page":"339","article-title":"\u2018... and found no shade\u2019. Coping processes of patients with erythropoietic protoporphyria","volume":"42","author":"Rufener","year":"1992","journal-title":"Psychother Psychosom Med Psychol"},{"key":"10.1111\/bjd.13598-BIB0008|bjd13598-cit-0008","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1365-2133.2008.08581.x","article-title":"The quality of life of 790\u00a0patients with photodermatoses","volume":"159","author":"Jong","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.13598-BIB0009|bjd13598-cit-0009","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1365-2133.1975.tb03051.x","article-title":"A study of physical light screening agents","volume":"92","author":"Macleod","year":"1975","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.13598-BIB0010|bjd13598-cit-0010","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1056\/NEJM197005282822204","article-title":"Beta-carotene as a photoprotective agent in erythropoietic protoporphyria","volume":"282","author":"Mathews-Roth","year":"1970","journal-title":"N Engl J Med"},{"key":"10.1111\/bjd.13598-BIB0011|bjd13598-cit-0011","first-page":"244","article-title":"A double-blind study of cysteine photoprotection in erythropoietic protoporphyria","volume":"10","author":"Mathews-Roth","year":"1994","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"10.1111\/bjd.13598-BIB0012|bjd13598-cit-0012","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1046\/j.1365-2133.2000.03442.x","article-title":"Therapeutic options for erythropoietic protoporphyria","volume":"142","author":"Todd","year":"2000","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.13598-BIB0013|bjd13598-cit-0013","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0016-5085(88)90627-0","article-title":"Fecal protoporphyrin excretion in erythropoietic protoporphyria: effect of cholestyramine and bile acid feeding","volume":"94","author":"McCullough","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1111\/bjd.13598-BIB0014|bjd13598-cit-0014","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.jaad.2012.02.006","article-title":"Oral cholestyramine is not an effective treatment for uncomplicated erythropoietic protoporphyria","volume":"67","author":"Tewari","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.13598-BIB0015|bjd13598-cit-0015","first-page":"84","article-title":"A systematic review of treatment options for dermal photosensitivity in erythropoietic protoporphyria","volume":"55","author":"Minder","year":"2009","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"10.1111\/bjd.13598-BIB0016|bjd13598-cit-0016","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1073\/pnas.77.10.5754","article-title":"4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity","volume":"77","author":"Sawyer","year":"1980","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/bjd.13598-BIB0017|bjd13598-cit-0017","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1517\/13543784.2010.535515","article-title":"Afamelanotide, an agonistic analog of alpha-melanocyte-stimulating hormone, in dermal phototoxicity of erythropoietic protoporphyria","volume":"19","author":"Minder","year":"2010","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1111\/bjd.13598-BIB0018|bjd13598-cit-0018","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1749-6632.1998.tb09577.x","article-title":"Cutaneous immunomodulation and coordination of skin stress responses by alpha-melanocyte-stimulating hormone","volume":"840","author":"Luger","year":"1998","journal-title":"Ann N Y Acad Sci"},{"key":"10.1111\/bjd.13598-BIB0019|bjd13598-cit-0019","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1056\/NEJMc0805682","article-title":"An alpha-melanocyte-stimulating hormone analogue in erythropoietic protoporphyria","volume":"360","author":"Harms","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1111\/bjd.13598-BIB0020|bjd13598-cit-0020","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1111\/j.1751-1097.2009.00595.x","article-title":"Mitigating photosensitivity of erythropoietic protoporphyria patients by an agonistic analog of alpha-melanocyte stimulating hormone","volume":"85","author":"Harms","year":"2009","journal-title":"Photochem Photobiol"},{"key":"10.1111\/bjd.13598-BIB0021|bjd13598-cit-0021","first-page":"eA12","article-title":"Afamelanotide implants effectively reduce pain and prolong sun-tolerance in patients with erythropoietic protoporphyria; results of a phase III, multicenter, double-blind, randomized, placebo-controlled trial","volume":"51","author":"Langendonk","year":"2013","journal-title":"Clin Chem Lab Med"},{"key":"10.1111\/bjd.13598-BIB0022|bjd13598-cit-0022","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1136\/bmj.311.7020.1621","article-title":"Clinical trials and rare diseases: a way out of a conundrum","volume":"311","author":"Lilford","year":"1995","journal-title":"BMJ"},{"key":"10.1111\/bjd.13598-BIB0023|bjd13598-cit-0023","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1001\/archderm.1977.01640090077011","article-title":"Beta carotene therapy for erythropoietic protoporphyria and other photosensitivity diseases","volume":"113","author":"Mathews-Roth","year":"1977","journal-title":"Arch Dermatol"},{"key":"10.1111\/bjd.13598-BIB0024|bjd13598-cit-0024","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1365-2133.2010.10104.x","article-title":"Systemic photoprotection in solar urticaria with alpha-melanocyte-stimulating hormone analogue [Nle4-D-Phe7]-alpha-MSH","volume":"164","author":"Haylett","year":"2011","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.13598-BIB0025|bjd13598-cit-0025","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/S0140-6736(08)60876-4","article-title":"Clinical trials of orphan medicines","volume":"371","author":"Buckley","year":"2008","journal-title":"Lancet"},{"key":"10.1111\/bjd.13598-BIB0026|bjd13598-cit-0026","first-page":"203","article-title":"The use of spectrophotometry to estimate melanin density in Caucasians","volume":"7","author":"Dwyer","year":"1998","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1111\/bjd.13598-BIB0027|bjd13598-cit-0027","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2165\/00002018-199920020-00002","article-title":"The medical dictionary for regulatory activities (MedDRA)","volume":"20","author":"Brown","year":"1999","journal-title":"Drug Saf"},{"key":"10.1111\/bjd.13598-BIB0028|bjd13598-cit-0028","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/0021-9681(87)90080-4","article-title":"A comparison of Likert and visual analogue scales for measuring change in function","volume":"40","author":"Guyatt","year":"1987","journal-title":"J Chronic Dis"},{"key":"10.1111\/bjd.13598-BIB0029|bjd13598-cit-0029","first-page":"1117","article-title":"The natural history of the pigmented nevus; factors of age and anatomic location","volume":"25","author":"Lund","year":"1949","journal-title":"Am J Pathol"},{"key":"10.1111\/bjd.13598-BIB0030|bjd13598-cit-0030","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1365-2133.2009.09362.x","article-title":"Eruptive melanocytic naevi following melanotan injection","volume":"161","author":"Cousen","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.13598-BIB0031|bjd13598-cit-0031","first-page":"b566","article-title":"Malignant melanoma in a user of melanotan I","volume":"338","author":"Ellis","year":"2009","journal-title":"BMJ"},{"key":"10.1111\/bjd.13598-BIB0032|bjd13598-cit-0032","first-page":"148","article-title":"Atypical melanocytic naevi following melanotan injection","volume":"106","author":"Reid","year":"2013","journal-title":"Ir Med J"},{"key":"10.1111\/bjd.13598-BIB0033|bjd13598-cit-0033","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1111\/j.1365-2133.2011.10273.x","article-title":"Melanotan-associated melanoma","volume":"164","author":"Paurobally","year":"2011","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.13598-BIB0034|bjd13598-cit-0034","doi-asserted-by":"crossref","first-page":"b566","DOI":"10.1136\/bmj.b566","article-title":"Use of melanotan I and II in the general population","volume":"338","author":"Evans-Brown","year":"2009","journal-title":"BMJ"},{"key":"10.1111\/bjd.13598-BIB0035|bjd13598-cit-0035","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1755-148X.2007.00433.x","article-title":"How to make a melanoma: what do we know of the primary clonal events?","volume":"21","author":"Bennett","year":"2008","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1111\/bjd.13598-BIB0036|bjd13598-cit-0036","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.5858\/2009-0418-RAR.1","article-title":"Molecular pathogenesis of sporadic melanoma and melanoma-initiating cells","volume":"134","author":"Kong","year":"2010","journal-title":"Arch Pathol Lab Med"},{"key":"10.1111\/bjd.13598-BIB0037|bjd13598-cit-0037","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1093\/hmg\/10.21.2397","article-title":"Functional variation of MC1R alleles from red-haired individuals","volume":"10","author":"Healy","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1111\/bjd.13598-BIB0038|bjd13598-cit-0038","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1046\/j.0022-202x.2001.01421.x","article-title":"Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color","volume":"117","author":"Kennedy","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.13598-BIB0039|bjd13598-cit-0039","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1002\/ijc.23396","article-title":"MC1R variants, melanoma and red hair color phenotype: a meta-analysis","volume":"122","author":"Raimondi","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1111\/bjd.13598-BIB0040|bjd13598-cit-0040","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1093\/hmg\/5.10.1663","article-title":"The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma","volume":"5","author":"Valverde","year":"1996","journal-title":"Hum Mol Genet"},{"key":"10.1111\/bjd.13598-BIB0041|bjd13598-cit-0041","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1242\/dev.02161","article-title":"Molecular characterization of melanocyte stem cells in their niche","volume":"132","author":"Osawa","year":"2005","journal-title":"Development"},{"key":"10.1111\/bjd.13598-BIB0042|bjd13598-cit-0042","doi-asserted-by":"crossref","first-page":"9328","DOI":"10.1158\/0008-5472.CAN-05-1343","article-title":"A tumorigenic subpopulation with stem cell properties in melanomas","volume":"65","author":"Fang","year":"2005","journal-title":"Cancer Res"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.13598","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.13598","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/bjd.13598\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T09:13:17Z","timestamp":1676365997000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/172\/6\/1601\/6616051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,30]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"URL":"https:\/\/doi.org\/10.1111\/bjd.13598","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725276565.793538142","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.725276565.793502653","asserted-by":"object"}]},"ISSN":["0007-0963"],"issn-type":[{"value":"0007-0963","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4,30]]}}}