{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:46:42Z","timestamp":1772995602839,"version":"3.50.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T00:00:00Z","timestamp":1427932800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T00:00:00Z","timestamp":1427932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Aage Bangs foundation"},{"name":"Copenhagen County Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Dermatol"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1111\/bjd.13651","type":"journal-article","created":{"date-parts":[[2015,1,10]],"date-time":"2015-01-10T06:45:16Z","timestamp":1420872316000},"page":"1519-1529","source":"Crossref","is-referenced-by-count":27,"title":["Skin reaction and regeneration after single sodium lauryl sulfate exposure stratified by filaggrin genotype and atopic dermatitis phenotype"],"prefix":"10.1093","volume":"172","author":[{"given":"J.","family":"Bandier","sequence":"first","affiliation":[{"name":"National Allergy Research Centre; Department of Dermato-Allergology; Copenhagen University Hospital Gentofte; Kildeg\u00e5rdsvej 28 2900 Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.C.","family":"Carlsen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre; Department of Dermato-Allergology; Copenhagen University Hospital Gentofte; Kildeg\u00e5rdsvej 28 2900 Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Faculty of Science; University of Copenhagen; Frederiksberg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.J.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine; Aalborg University Hospital; Aalborg Denmark"},{"name":"Department of Clinical Medicine; Aalborg University Hospital; Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre; Department of Dermato-Allergology; Copenhagen University Hospital Gentofte; Kildeg\u00e5rdsvej 28 2900 Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,4,2]]},"reference":[{"key":"10.1111\/bjd.13651-BIB0001|bjd13651-cit-0001","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1242\/jcs.033969","article-title":"Filaggrin in the frontline: role in skin barrier function and disease","volume":"122","author":"Sandilands","year":"2009","journal-title":"J Cell Sci"},{"key":"10.1111\/bjd.13651-BIB0002|bjd13651-cit-0002","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1440-0960.2008.00443.x","article-title":"Filaggrin and the great epidermal barrier grief","volume":"49","author":"McGrath","year":"2008","journal-title":"Australas J Dermatol"},{"key":"10.1111\/bjd.13651-BIB0003|bjd13651-cit-0003","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.molmed.2007.10.006","article-title":"The filaggrin story: novel insights into skin-barrier function and disease","volume":"14","author":"McGrath","year":"2008","journal-title":"Trends Mol Med"},{"key":"10.1111\/bjd.13651-BIB0004|bjd13651-cit-0004","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/ng2020","article-title":"Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema","volume":"39","author":"Sandilands","year":"2007","journal-title":"Nat Genet"},{"key":"10.1111\/bjd.13651-BIB0005|bjd13651-cit-0005","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ng1743","article-title":"Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris","volume":"38","author":"Smith","year":"2006","journal-title":"Nat Genet"},{"key":"10.1111\/bjd.13651-BIB0006|bjd13651-cit-0006","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/sj.ejhg.5201742","article-title":"Filaggrin mutations p. R501X and c.2282del4 in ichthyosis vulgaris","volume":"15","author":"Gruber","year":"2006","journal-title":"Eur J Hum Genet"},{"key":"10.1111\/bjd.13651-BIB0007|bjd13651-cit-0007","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1365-2133.2008.08730.x","article-title":"Loss-of-function polymorphisms in the filaggrin gene are associated with an increased susceptibility to chronic irritant contact dermatitis: a case-control study","volume":"159","author":"Jongh","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.13651-BIB0008|bjd13651-cit-0008","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1600-0536.2008.01317.x","article-title":"Cytokine gene polymorphisms and susceptibility to chronic irritant contact dermatitis","volume":"58","author":"Jongh","year":"2008","journal-title":"Contact Dermatitis"},{"key":"10.1111\/bjd.13651-BIB0009|bjd13651-cit-0009","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1600-0536.1997.tb00041.x","article-title":"Guidelines on sodium lauryl sulfate (SLS) exposure tests","volume":"37","author":"Tupker","year":"1997","journal-title":"Contact Dermatitis"},{"key":"10.1111\/bjd.13651-BIB0010|bjd13651-cit-0010","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1600-0536.1999.tb06082.x","article-title":"Irritancy ranking of anionic detergents using one-time occlusive, repeated occlusive and repeated open tests","volume":"40","author":"Tupker","year":"1999","journal-title":"Contact Dermatitis"},{"key":"10.1111\/bjd.13651-BIB0011|bjd13651-cit-0011","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-3-642-03827-3_2","volume-title":"Contact Dermatitis","author":"Schnuch","year":"2011","edition":"5"},{"key":"10.1111\/bjd.13651-BIB0012|bjd13651-cit-0012","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1600-0536.1981.tb04059.x","article-title":"Thoughts on irritant contact dermatitis","volume":"7","author":"Malten","year":"1981","journal-title":"Contact Dermatitis"},{"key":"10.1111\/bjd.13651-BIB0013|bjd13651-cit-0013","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1038\/jid.2010.115","article-title":"Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model","volume":"130","author":"Mildner","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.13651-BIB0014|bjd13651-cit-0014","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jaci.2009.06.046","article-title":"Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens","volume":"124","author":"Scharschmidt","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/bjd.13651-BIB0015|bjd13651-cit-0015","doi-asserted-by":"crossref","first-page":"296","DOI":"10.2340\/0001555571296300","article-title":"Susceptibility of atopic dermatitis patients to irritant dermatitis caused by sodium lauryl sulphate","volume":"71","author":"Agner","year":"1991","journal-title":"Acta Derm Venereol"},{"key":"10.1111\/bjd.13651-BIB0016|bjd13651-cit-0016","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-2133.1990.tb01847.x","article-title":"Susceptibility to irritants: role of barrier function, skin dryness and history of atopic dermatitis","volume":"123","author":"Tupker","year":"1990","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.13651-BIB0017|bjd13651-cit-0017","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1398-9995.2010.02326.x","article-title":"Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema","volume":"65","author":"Jungersted","year":"2010","journal-title":"Allergy"},{"key":"10.1111\/bjd.13651-BIB0018|bjd13651-cit-0018","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1600-0625.2011.01259.x","article-title":"Distinct barrier integrity phenotypes in filaggrin-related atopic eczema following sequential tape stripping and lipid profiling","volume":"20","author":"Angelova-Fischer","year":"2011","journal-title":"Exp Dermatol"},{"key":"10.1111\/bjd.13651-BIB0019|bjd13651-cit-0019","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1111\/jdv.12079","article-title":"Complete filaggrin deficiency in ichthyosis vulgaris is associated with only moderate changes in epidermal permeability barrier function profile","volume":"27","author":"Perusqu\u00eda-Ortiz","year":"2013","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1111\/bjd.13651-BIB0020|bjd13651-cit-0020","doi-asserted-by":"crossref","first-page":"640","DOI":"10.2340\/00015555-1815","article-title":"Skin barrier integrity and natural moisturising factor levels after cumulative dermal exposure to alkaline agents in atopic dermatitis","volume":"94","author":"Angelova-Fischer","year":"2014","journal-title":"Acta Derm Venereol"},{"key":"10.1111\/bjd.13651-BIB0021|bjd13651-cit-0021","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/sj.jid.5701170","article-title":"Skin barrier disruption by sodium lauryl sulfate-exposure alters the expressions of involucrin, transglutaminase 1, profilaggrin, and kallikreins during the repair phase in human skin in vivo","volume":"128","author":"Torma","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.13651-BIB0022|bjd13651-cit-0022","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1365-2133.1994.tb08530.x","article-title":"The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. I. Derivation of a minimum set of discriminators for atopic dermatitis","volume":"131","author":"Williams","year":"1994","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.13651-BIB0023|bjd13651-cit-0023","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/j.cca.2012.06.014","article-title":"A novel multiplex analysis of filaggrin polymorphisms: a universally applicable method for genotyping","volume":"413","author":"Meldgaard","year":"2012","journal-title":"Clin Chim Acta"},{"key":"10.1111\/bjd.13651-BIB0024|bjd13651-cit-0024","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1600-0536.1990.tb01553.x","article-title":"Guidelines for transepidermal water loss (TEWL) measurement","volume":"22","author":"Pinnagoda","year":"1990","journal-title":"Contact Dermatitis"},{"key":"10.1111\/bjd.13651-BIB0025|bjd13651-cit-0025","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1093\/bioinformatics\/bti476","article-title":"anova-simultaneous component analysis (ASCA): a new tool for analyzing designed metabolomics data","volume":"21","author":"Smilde","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1111\/bjd.13651-BIB0026|bjd13651-cit-0026","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/DER.0000000000000045","article-title":"Skin pH, atopic dermatitis, and filaggrin mutations","volume":"25","author":"Bandier","year":"2014","journal-title":"Dermatitis"},{"key":"10.1111\/bjd.13651-BIB0027|bjd13651-cit-0027","first-page":"1","article-title":"Hand eczema and long-term prognosis in atopic dermatitis","volume":"117","author":"Rystedt","year":"1985","journal-title":"Acta Derm Venereol Suppl (Stockh)"},{"key":"10.1111\/bjd.13651-BIB0028|bjd13651-cit-0028","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/ng1767","article-title":"Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis","volume":"38","author":"Palmer","year":"2006","journal-title":"Nat Genet"},{"key":"10.1111\/bjd.13651-BIB0029|bjd13651-cit-0029","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1056\/NEJMra1011040","article-title":"Filaggrin mutations associated with skin and allergic diseases","volume":"365","author":"Irvine","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1111\/bjd.13651-BIB0030|bjd13651-cit-0030","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/jid.2010.307","article-title":"Skin barrier function in healthy subjects and patients with atopic dermatitis in relation to filaggrin loss-of-function mutations","volume":"131","author":"Jakasa","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.13651-BIB0031|bjd13651-cit-0031","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/bjd.12743","article-title":"Severe skin inflammation and filaggrin mutation similarly alter the skin barrier in patients with atopic dermatitis","volume":"170","author":"Mocsai","year":"2014","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.13651-BIB0032|bjd13651-cit-0032","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1365-2230.1985.tb00535.x","article-title":"Vulnerability of the skin to surfactants in different groups of eczema patients and controls as measured by water vapour loss","volume":"10","author":"Valk","year":"1985","journal-title":"Clin Exp Dermatol"},{"key":"10.1111\/bjd.13651-BIB0033|bjd13651-cit-0033","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/jid.2008.280","article-title":"Clinical severity correlates with impaired barrier in filaggrin-related eczema","volume":"129","author":"Nemoto-Hasebe","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.13651-BIB0034|bjd13651-cit-0034","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1111\/j.1398-9995.2010.02540.x","article-title":"Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity","volume":"66","author":"Kezic","year":"2011","journal-title":"Allergy"},{"key":"10.1111\/bjd.13651-BIB0035|bjd13651-cit-0035","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/1523-1747.ep12504896","article-title":"Sodium lauryl sulphate for irritant patch testing - a dose-response study using bioengineering methods for determination of skin irritation","volume":"95","author":"Agner","year":"1990","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.13651-BIB0036|bjd13651-cit-0036","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s00011-013-0668-2","article-title":"Direct comparison of laser Doppler flowmetry and laser Doppler imaging for assessment of experimentally-induced inflammation in human skin","volume":"62","author":"Petersen","year":"2013","journal-title":"Inflamm Res"},{"key":"10.1111\/bjd.13651-BIB0037|bjd13651-cit-0037","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00011-010-0189-1","article-title":"A novel model of inflammatory pain in human skin involving topical application of sodium lauryl sulfate","volume":"59","author":"Petersen","year":"2010","journal-title":"Inflamm Res"},{"key":"10.1111\/bjd.13651-BIB0038|bjd13651-cit-0038","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.jaci.2012.12.1566","article-title":"Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin","volume":"131","author":"Pellerin","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/bjd.13651-BIB0039|bjd13651-cit-0039","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/bjd.12083","article-title":"Impact of atopic dermatitis and loss-of-function mutations in the filaggrin gene on the development of occupational irritant contact dermatitis","volume":"168","author":"Visser","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.13651-BIB0040|bjd13651-cit-0040","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1365-2133.2010.09822.x","article-title":"Filaggrin null mutations increase the risk and persistence of hand eczema in subjects with atopic dermatitis: results from a general population study","volume":"163","author":"Thyssen","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.13651-BIB0041|bjd13651-cit-0041","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/cod.12097","article-title":"Carriers of filaggrin gene (FLG) mutations avoid professional exposure to irritants in adulthood","volume":"69","author":"Bandier","year":"2013","journal-title":"Contact Dermatitis"},{"issue":"3 Suppl. 2","key":"10.1111\/bjd.13651-BIB0042|bjd13651-cit-0042","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1016\/j.jaci.2009.07.012","article-title":"Cytokine modulation of atopic dermatitis filaggrin skin expression","volume":"124","author":"Howell","year":"2009","journal-title":"J Allergy Clin Immun"},{"key":"10.1111\/bjd.13651-BIB0043|bjd13651-cit-0043","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1600-0536.1999.tb06158.x","article-title":"The influence of patch test size and design on the distribution of erythema induced by sodium lauryl sulfate","volume":"41","author":"Nicholson","year":"1999","journal-title":"Contact Dermatitis"},{"key":"10.1111\/bjd.13651-BIB0044|bjd13651-cit-0044","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-2230.1990.tb02014.x","article-title":"Individual and instrumental variations in irritant patch-test reactions - clinical evaluation and quantification by bioengineering methods","volume":"15","author":"Agner","year":"1990","journal-title":"Clin Exp Dermatol"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.13651","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.13651","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/bjd.13651\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T19:25:21Z","timestamp":1690831521000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/172\/6\/1519\/6615822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,2]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"URL":"https:\/\/doi.org\/10.1111\/bjd.13651","archive":["Portico"],"relation":{},"ISSN":["0007-0963"],"issn-type":[{"value":"0007-0963","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4,2]]}}}