{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:01:41Z","timestamp":1792036901295,"version":"4.4.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CoDa Therapeutics Inc."},{"DOI":"10.13039\/501100011738","name":"Lee Kong Chian School of Medicine","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011738","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001475","name":"Nanyang Technological University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001475","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Singapore Ministry of Education Academic Research Fund","award":["2014-T1-002-098"],"award-info":[{"award-number":["2014-T1-002-098"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Dermatol"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1111\/bjd.14064","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T05:28:06Z","timestamp":1439357286000},"page":"1205-1215","source":"Crossref","is-referenced-by-count":49,"title":["Abnormal connexin expression in human chronic wounds"],"prefix":"10.1093","volume":"173","author":[{"given":"J.E.S.","family":"Sutcliffe","sequence":"first","affiliation":[{"name":"Department of Cell and Developmental Biology; University College London; Gower Street London WC1E 6BT U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.Y.","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology; University College London; Gower Street London WC1E 6BT U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Thrasivoulou","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology; University College London; Gower Street London WC1E 6BT U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.E.","family":"Serena","sequence":"additional","affiliation":[{"name":"Newbridge Medical Research Corp.; Warren PA 16365 U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"O'Neil","sequence":"additional","affiliation":[{"name":"CoDa Therapeutics; 10 College Hill Auckland 1011 New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Hu","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine; Nanyang Technological University; 11 Mandalay Road Singapore 308232 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"White","sequence":"additional","affiliation":[{"name":"CoDa Therapeutics; 10 College Hill Auckland 1011 New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Madden","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine; Nanyang Technological University; 11 Mandalay Road Singapore 308232 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Richards","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology; University College London; Gower Street London WC1E 6BT U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.R.J.","family":"Phillips","sequence":"additional","affiliation":[{"name":"CoDa Therapeutics; 10 College Hill Auckland 1011 New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.L.","family":"Becker","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine; Nanyang Technological University; 11 Mandalay Road Singapore 308232 Singapore"},{"name":"Institute of Medical Biology; A*STAR; 138648 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,10,11]]},"reference":[{"key":"10.1111\/bjd.14064-BIB0001|bjd14064-cit-0001","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1524-475X.2009.00543.x","article-title":"Human skin wounds: a major and snowballing threat to public health and the economy","volume":"17","author":"Sen","year":"2009","journal-title":"Wound Repair Regen"},{"key":"10.1111\/bjd.14064-BIB0002|bjd14064-cit-0002","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1097\/01.PHM.0000140800.83146.FA","article-title":"Assessing persistent pain and its relation to affective distress, depressive symptoms, and pain catastrophizing in patients with chronic wounds: a pilot study","volume":"83","author":"Roth","year":"2004","journal-title":"Am J Phys Med Rehabil"},{"key":"10.1111\/bjd.14064-BIB0003|bjd14064-cit-0003","doi-asserted-by":"crossref","first-page":"65S","DOI":"10.1016\/S0002-9610(03)00306-4","article-title":"Understanding chronic wounds: a unifying hypothesis on their pathogenesis and implications for therapy","volume":"187","author":"Mustoe","year":"2004","journal-title":"Am J Surg"},{"key":"10.1111\/bjd.14064-BIB0004|bjd14064-cit-0004","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.diabres.2009.10.007","article-title":"Global estimates of the prevalence of diabetes for 2010 and 2030","volume":"87","author":"Shaw","year":"2010","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1111\/bjd.14064-BIB0005|bjd14064-cit-0005","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/ndt\/gfq576","article-title":"Diabesity: an overview of a rising epidemic","volume":"26","author":"Farag","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1111\/bjd.14064-BIB0006|bjd14064-cit-0006","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1046\/j.1524-475X.1994.20305.x","article-title":"Definitions and guidelines for assessment of wounds and evaluation of healing","volume":"2","author":"Lazarus","year":"1994","journal-title":"Wound Repair Regen"},{"key":"10.1111\/bjd.14064-BIB0007|bjd14064-cit-0007","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1016\/j.bbamem.2011.09.004","article-title":"Connexins in epidermal homeostasis and skin disease","volume":"1818","author":"Scott","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1111\/bjd.14064-BIB0008|bjd14064-cit-0008","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1046\/j.0022-202x.2001.01468.x","article-title":"Multiple epidermal connexins are expressed in different keratinocyte subpopulations including connexin 31","volume":"117","author":"Di","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.14064-BIB0009|bjd14064-cit-0009","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/1523-1747.ep12616154","article-title":"Gap-junctional protein connexin 43 is expressed in dermis and epidermis of human skin: differential modulation by retinoids","volume":"99","author":"Guo","year":"1992","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.14064-BIB0010|bjd14064-cit-0010","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1091\/mbc.6.11.1491","article-title":"Wounding alters epidermal connexin expression and gap junction-mediated intercellular communication","volume":"6","author":"Goliger","year":"1995","journal-title":"Mol Biol Cell"},{"key":"10.1111\/bjd.14064-BIB0011|bjd14064-cit-0011","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1065-6995(03)00077-5","article-title":"Dynamic changes in connexin expression correlate with key events in the wound healing process","volume":"27","author":"Coutinho","year":"2003","journal-title":"Cell Biol Int"},{"key":"10.1111\/bjd.14064-BIB0012|bjd14064-cit-0012","doi-asserted-by":"crossref","first-page":"e37374","DOI":"10.1371\/journal.pone.0037374","article-title":"Targeting Cx43 and N-cadherin, which are abnormally upregulated in venous leg ulcers, influences migration, adhesion and activation of Rho GTPases","volume":"7","author":"Mendoza-Naranjo","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1111\/bjd.14064-BIB0013|bjd14064-cit-0013","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1042\/CBI20110628","article-title":"Overexpression of the gap junction protein Cx43 as found in diabetic foot ulcers can retard fibroblast migration","volume":"36","author":"Mendoza-Naranjo","year":"2012","journal-title":"Cell Biol Int"},{"key":"10.1111\/bjd.14064-BIB0014|bjd14064-cit-0014","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/j.cub.2003.09.007","article-title":"Targeting connexin43 expression accelerates the rate of wound repair","volume":"13","author":"Qiu","year":"2003","journal-title":"Curr Biol"},{"key":"10.1111\/bjd.14064-BIB0015|bjd14064-cit-0015","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1242\/jcs.03320","article-title":"Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation and wound fibroblast migration","volume":"119","author":"Mori","year":"2006","journal-title":"J Cell Sci"},{"key":"10.1111\/bjd.14064-BIB0016|bjd14064-cit-0016","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1242\/jcs.00638","article-title":"Altered connexin expression and wound healing in the epidermis of connexin-deficient mice","volume":"116","author":"Kretz","year":"2003","journal-title":"J Cell Sci"},{"key":"10.1111\/bjd.14064-BIB0017|bjd14064-cit-0017","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00210-013-0840-9","article-title":"The antiarrhythmic dipeptide ZP1609 (danegaptide) when given at reperfusion reduces myocardial infarct size in pigs","volume":"386","author":"Skyschally","year":"2013","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1111\/bjd.14064-BIB0018|bjd14064-cit-0018","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2217\/17460751.4.2.205","article-title":"Connexin43 carboxyl-terminal peptides reduce scar progenitor and promote regenerative healing following skin wounding","volume":"4","author":"Ghatnekar","year":"2009","journal-title":"Regen Med"},{"key":"10.1111\/bjd.14064-BIB0019|bjd14064-cit-0019","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1089\/wound.2011.0341","article-title":"A connexin43 mimetic peptide promotes regenerative healing and improves mechanical properties in skin and heart","volume":"2","author":"Ongstad","year":"2013","journal-title":"Adv Wound Care"},{"key":"10.1111\/bjd.14064-BIB0020|bjd14064-cit-0020","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1113\/jphysiol.1995.sp021003","article-title":"Specific motifs in the external loops of connexin proteins can determine gap junction formation between chick heart myocytes","volume":"488","author":"Warner","year":"1995","journal-title":"J Physiol"},{"key":"10.1111\/bjd.14064-BIB0021|bjd14064-cit-0021","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1042\/bst0290606","article-title":"Connexin mimetic peptides: specific inhibitors of gap-junctional intercellular communication","volume":"29","author":"Evans","year":"2001","journal-title":"Biochem Soc Trans"},{"key":"10.1111\/bjd.14064-BIB0022|bjd14064-cit-0022","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00232-012-9488-5","article-title":"Manipulating connexin communication channels: use of peptidomimetics and the translational outputs","volume":"245","author":"Evans","year":"2012","journal-title":"J Membr Biol"},{"key":"10.1111\/bjd.14064-BIB0023|bjd14064-cit-0023","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.2337\/db07-0613","article-title":"Abnormal connexin expression underlies delayed wound healing in diabetic skin","volume":"56","author":"Wang","year":"2007","journal-title":"Diabetes"},{"key":"10.1111\/bjd.14064-BIB0024|bjd14064-cit-0024","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1111\/j.0022-202X.2004.22529.x","article-title":"Connexins 26, 30, and 43: differences among spontaneous, chronic, and accelerated human wound healing","volume":"122","author":"Brandner","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.14064-BIB0025|bjd14064-cit-0025","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1046\/j.1432-1327.1999.00343.x","article-title":"Assembly of heteromeric connexons in guinea-pig liver en route to the Golgi apparatus, plasma membrane and gap junctions","volume":"262","author":"Diez","year":"1999","journal-title":"Eur J Biochem"},{"key":"10.1111\/bjd.14064-BIB0026|bjd14064-cit-0026","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/1523-1747.ep12334217","article-title":"Identification of aberrantly regulated genes in diseased skin using the cDNA differential display technique","volume":"108","author":"Rivas","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.14064-BIB0027|bjd14064-cit-0027","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1046\/j.1523-1747.1998.00248.x","article-title":"Upregulation of connexin 26 between keratinocytes of psoriatic lesions","volume":"111","author":"Labarthe","year":"1998","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.14064-BIB0028|bjd14064-cit-0028","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1083\/jcb.200404142","article-title":"Protein kinase C spatially and temporally regulates gap junctional communication during human wound repair via phosphorylation of connexin43 on serine368","volume":"167","author":"Richards","year":"2004","journal-title":"J Cell Biol"},{"key":"10.1111\/bjd.14064-BIB0029|bjd14064-cit-0029","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1016\/j.bbamem.2011.12.009","article-title":"Gap junctional channels are parts of multiprotein complexes","volume":"1818","author":"Herv\u00e9","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1111\/bjd.14064-BIB0030|bjd14064-cit-0030","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000316942","article-title":"Connexin channel-dependent signaling pathways in inflammation","volume":"48","author":"Scheckenbach","year":"2011","journal-title":"J Vasc Res"},{"key":"10.1111\/bjd.14064-BIB0031|bjd14064-cit-0031","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.mcn.2008.06.005","article-title":"Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury","volume":"39","author":"Cronin","year":"2008","journal-title":"Mol Cell Neurosci"},{"key":"10.1111\/bjd.14064-BIB0032|bjd14064-cit-0032","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1111\/j.1582-4934.2008.00654.x","article-title":"Connexin43 modulates neutrophil recruitment to the lung","volume":"13","author":"Sarieddine","year":"2009","journal-title":"J Cell Mol Med"},{"key":"10.1111\/bjd.14064-BIB0033|bjd14064-cit-0033","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1046\/j.1523-1747.1999.00512.x","article-title":"Upregulation of connexin 26 is a feature of keratinocyte differentiation in hyperproliferative epidermis, vaginal epithelium, and buccal epithelium","volume":"112","author":"Lucke","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.14064-BIB0034|bjd14064-cit-0034","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/j.1365-2133.2006.07439.x","article-title":"Connexin 30, a new marker of hyperproliferative epidermis","volume":"155","author":"Lema\u00eetre","year":"2006","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.14064-BIB0035|bjd14064-cit-0035","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.0303-6987.2004.00247.x","article-title":"Gene expression profiling of porokeratosis demonstrates similarities with psoriasis","volume":"31","author":"Hivnor","year":"2004","journal-title":"J Cutan Pathol"},{"key":"10.1111\/bjd.14064-BIB0036|bjd14064-cit-0036","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1111\/j.1582-4934.2008.00321.x","article-title":"Deregulation of keratinocyte differentiation and activation: a hallmark of venous ulcers","volume":"12","author":"Stojadinovic","year":"2008","journal-title":"J Cell Mol Med"},{"key":"10.1111\/bjd.14064-BIB0037|bjd14064-cit-0037","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1369\/jhc.2008.951194","article-title":"Keratinocyte migration, proliferation, and differentiation in chronic ulcers from patients with diabetes and normal wounds","volume":"56","author":"Usui","year":"2008","journal-title":"J Histochem Cytochem"},{"key":"10.1111\/bjd.14064-BIB0038|bjd14064-cit-0038","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1172\/JCI27186","article-title":"Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response","volume":"116","author":"Djalilian","year":"2006","journal-title":"J Clin Invest"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.14064","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/bjd.14064\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T14:17:02Z","timestamp":1676384222000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/173\/5\/1205\/6616834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,11]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,11]]}},"URL":"https:\/\/doi.org\/10.1111\/bjd.14064","archive":["Portico"],"relation":{},"ISSN":["0007-0963"],"issn-type":[{"value":"0007-0963","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10,11]]}}}