{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:45:55Z","timestamp":1784673955054,"version":"3.55.0"},"reference-count":196,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Dermatol"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1111\/bjd.15001","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T08:32:44Z","timestamp":1472027564000},"page":"34-46","source":"Crossref","is-referenced-by-count":48,"title":["The molecular pathogenesis of morphoea: from genetics to future treatment targets"],"prefix":"10.1093","volume":"177","author":[{"given":"A.M.","family":"Saracino","sequence":"first","affiliation":[{"name":"The Royal Free London NHS Foundation Trust; Department of Dermatology; London U.K"},{"name":"University College London; Centre for Rheumatology and Connective Tissue Diseases; Division of Medicine; London U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.P.","family":"Denton","sequence":"additional","affiliation":[{"name":"University College London; Centre for Rheumatology and Connective Tissue Diseases; Division of Medicine; London U.K"},{"name":"The Royal Free London NHS Foundation Trust; Department of Rheumatology; London U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.H.","family":"Orteu","sequence":"additional","affiliation":[{"name":"The Royal Free London NHS Foundation Trust; Department of Dermatology; London U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,5,30]]},"reference":[{"key":"10.1111\/bjd.15001-BIB0001|bjd15001-cit-0001","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1002\/art.38814","article-title":"Major histocompatibility complex class I and class II alleles may confer susceptibility to or protection against morphea: findings from the Morphea in Adults and Children cohort","volume":"66","author":"Jacobe","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1111\/bjd.15001-BIB0002|bjd15001-cit-0002","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1001\/archdermatol.2009.79","article-title":"Distinct autoimmune syndromes in morphea: a review of 245 adult and pediatric cases","volume":"145","author":"Leitenberger","year":"2009","journal-title":"Arch Dermatol"},{"key":"10.1111\/bjd.15001-BIB0003|bjd15001-cit-0003","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5070\/D383K6X3TB","article-title":"Familial linear scleroderma (en coup de sabre) responsive to antimalarials and narrowband ultraviolet B therapy","volume":"13","author":"Brownell","year":"2007","journal-title":"Dermatol Online J"},{"key":"10.1111\/bjd.15001-BIB0004|bjd15001-cit-0004","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.ijporl.2004.12.004","article-title":"Familial Parry-Romberg disease","volume":"69","author":"Anderson","year":"2005","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"10.1111\/bjd.15001-BIB0005|bjd15001-cit-0005","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/rheumatology\/kei251","article-title":"Juvenile localized scleroderma: clinical and epidemiological features in 750 children. An international study","volume":"45","author":"Zulian","year":"2006","journal-title":"Rheumatology"},{"key":"10.1111\/bjd.15001-BIB0006|bjd15001-cit-0006","first-page":"73","article-title":"The epidemiology of morphea (localized scleroderma) in Olmsted County 1960-1993","volume":"24","author":"Peterson","year":"1997","journal-title":"J Rheumatol"},{"key":"10.1111\/bjd.15001-BIB0007|bjd15001-cit-0007","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/bjd.12758","article-title":"Risk factors for morphoea disease severity: a retrospective review of 114 paediatric patients","volume":"170","author":"Pequet","year":"2014","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.15001-BIB0008|bjd15001-cit-0008","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3899\/jrheum.130029","article-title":"Clinical features of patients with morphea and the pansclerotic subtype: a cross-sectional study from the morphea in adults and children cohort","volume":"41","author":"Kim","year":"2014","journal-title":"J Rheumatol"},{"key":"10.1111\/bjd.15001-BIB0009|bjd15001-cit-0009","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.jaad.2012.04.003","article-title":"Coexistence of lichen sclerosus and morphea: a retrospective analysis of 472 patients with localized scleroderma from a German tertiary referral center","volume":"67","author":"Kreuter","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.15001-BIB0010|bjd15001-cit-0010","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1365-2133.1989.tb01350.x","article-title":"An investigation into the incidence of auto-immune disorders in patients with localized morphoea","volume":"120","author":"Harrington","year":"1989","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.15001-BIB0011|bjd15001-cit-0011","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1002\/art.21264","article-title":"Localized scleroderma in childhood is not just a skin disease","volume":"52","author":"Zulian","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1111\/bjd.15001-BIB0012|bjd15001-cit-0012","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/S0190-9622(87)70251-5","article-title":"Frequency, levels, and significance of blood eosinophilia in systemic sclerosis, localized scleroderma, and eosinophilic fasciitis","volume":"17","author":"Falanga","year":"1987","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.15001-BIB0013|bjd15001-cit-0013","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1001\/archderm.1987.01660270088021","article-title":"Antinuclear and anti-single-stranded DNA antibodies in morphea and generalized morphea","volume":"123","author":"Falanga","year":"1987","journal-title":"Arch Dermatol"},{"key":"10.1111\/bjd.15001-BIB0014|bjd15001-cit-0014","first-page":"171","article-title":"Localized scleroderma in adults and children. Clinical and laboratory investigations on 239 cases","volume":"13","author":"Marzano","year":"2003","journal-title":"Eur J Dermatol"},{"key":"10.1111\/bjd.15001-BIB0015|bjd15001-cit-0015","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/art.1780370618","article-title":"Serum levels of soluble interleukin-2 receptor. A marker of disease activity in localized scleroderma","volume":"37","author":"Uziel","year":"1994","journal-title":"Arthritis Rheum"},{"key":"10.1111\/bjd.15001-BIB0016|bjd15001-cit-0016","first-page":"2337","article-title":"Antinuclear antibodies in children with localized scleroderma","volume":"22","author":"Rosenberg","year":"1995","journal-title":"J Rheumatol"},{"key":"10.1111\/bjd.15001-BIB0017|bjd15001-cit-0017","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0190-9622(86)70217-X","article-title":"Anticentromere antibody in localized scleroderma","volume":"15","author":"Ruffatti","year":"1986","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.15001-BIB0018|bjd15001-cit-0018","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/art.1780260506","article-title":"Antinuclear antibodies in localized scleroderma","volume":"26","author":"Takehara","year":"1983","journal-title":"Arthritis Rheum"},{"key":"10.1111\/bjd.15001-BIB0019|bjd15001-cit-0019","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1002\/art.1780390624","article-title":"Childhood-onset scleroderma: is it different from adult-onset disease","volume":"39","author":"Vancheeswaran","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1111\/bjd.15001-BIB0020|bjd15001-cit-0020","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1001\/jamadermatol.2013.4207","article-title":"Morphea in adults and children cohort III: nested case-control study - the clinical significance of autoantibodies in morphea","volume":"149","author":"Dharamsi","year":"2013","journal-title":"JAMA Dermatol"},{"key":"10.1111\/bjd.15001-BIB0021|bjd15001-cit-0021","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/jid.2011.472","article-title":"Intrinsic gene expression subsets of diffuse cutaneous systemic sclerosis are stable in serial skin biopsies","volume":"132","author":"Pendergrass","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.15001-BIB0022|bjd15001-cit-0022","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/jid.2009.318","article-title":"A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity","volume":"130","author":"Sargent","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.15001-BIB0023|bjd15001-cit-0023","doi-asserted-by":"crossref","first-page":"e2696","DOI":"10.1371\/journal.pone.0002696","article-title":"Molecular subsets in the gene expression signatures of scleroderma skin","volume":"3","author":"Milano","year":"2008","journal-title":"PLOS ONE"},{"key":"10.1111\/bjd.15001-BIB0024|bjd15001-cit-0024","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1586\/eci.11.41","article-title":"Capturing the heterogeneity in systemic sclerosis with genome-wide expression profiling","volume":"7","author":"Sargent","year":"2011","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1111\/bjd.15001-BIB0025|bjd15001-cit-0025","doi-asserted-by":"crossref","first-page":"12319","DOI":"10.1073\/pnas.1635114100","article-title":"Systemic and cell type-specific gene expression patterns in scleroderma skin","volume":"100","author":"Whitfield","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/bjd.15001-BIB0026|bjd15001-cit-0026","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1002\/art.21894","article-title":"Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts","volume":"54","author":"Gardner","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1111\/bjd.15001-BIB0027|bjd15001-cit-0027","doi-asserted-by":"crossref","first-page":"R188","DOI":"10.1186\/ar4378","article-title":"Interferon-gamma inducible protein-10 as a potential biomarker in localized scleroderma","volume":"15","author":"Magee","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"10.1111\/bjd.15001-BIB0028|bjd15001-cit-0028","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1365-2133.1976.tb00835.x","article-title":"The lines of Blaschko: a review and reconsideration: observations of the cause of certain unusual linear conditions of the skin","volume":"95","author":"Jackson","year":"1976","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.15001-BIB0029|bjd15001-cit-0029","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0190-9622(94)70143-1","article-title":"Lines of Blaschko","volume":"31","author":"Bolognia","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.15001-BIB0030|bjd15001-cit-0030","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.1365-2133.1996.tb16254.x","article-title":"Morphoea following Blaschko's lines","volume":"134","author":"Hauser","year":"1996","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.15001-BIB0031|bjd15001-cit-0031","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0190-9622(98)70586-9","article-title":"Frontoparietal scleroderma (en coup de sabre) following Blaschko's lines","volume":"38","author":"Soma","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.15001-BIB0032|bjd15001-cit-0032","first-page":"362","article-title":"Linear scleroderma along Blaschko's lines in a patient with systematized morphea","volume":"83","author":"Soma","year":"2003","journal-title":"Acta Dermatovenereol"},{"key":"10.1111\/bjd.15001-BIB0033|bjd15001-cit-0033","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1046\/j.1365-2230.1999.00535.x","article-title":"A tri-linear pattern of scleroderma \u2018en coup de sabre\u2019 following Blaschko's lines","volume":"24","author":"McKenna","year":"1999","journal-title":"Clin Exp Dermatol"},{"key":"10.1111\/bjd.15001-BIB0034|bjd15001-cit-0034","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000018236","article-title":"Double-lined frontoparietal scleroderma en coup de sabre","volume":"199","author":"Itin","year":"1999","journal-title":"Dermatology"},{"key":"10.1111\/bjd.15001-BIB0035|bjd15001-cit-0035","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4103\/0378-6323.18949","article-title":"Linear scleroderma following Blaschko's lines","volume":"71","author":"Mukhopadhyay","year":"2005","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"10.1111\/bjd.15001-BIB0036|bjd15001-cit-0036","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/j.1365-2230.2007.02521.x","article-title":"An unusual manifestation of linear scleroderma \u2018en coup de sabre\u2019 on the vertex and frontoparietal regions","volume":"32","author":"Asano","year":"2007","journal-title":"Clin Exp Dermatol"},{"key":"10.1111\/bjd.15001-BIB0037|bjd15001-cit-0037","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1046\/j.1525-1470.2000.01757.x","article-title":"Bilateral en coup de sabre - a rare entity","volume":"17","author":"Rai","year":"2000","journal-title":"Pediatr Dermatol"},{"key":"10.1111\/bjd.15001-BIB0038|bjd15001-cit-0038","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1365-2133.2008.08647.x","article-title":"Linear morphoea follows Blaschko's lines","volume":"159","author":"Weibel","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.15001-BIB0039|bjd15001-cit-0039","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1346-8138.2010.01162.x","article-title":"Digital image processing for the acquisition of graphic similarity of the distributional patterns between cutaneous lesions of linear scleroderma and Blaschko's lines","volume":"38","author":"Jue","year":"2011","journal-title":"J Dermatol"},{"key":"10.1111\/bjd.15001-BIB0040|bjd15001-cit-0040","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/ng0707-820","article-title":"Wnt signaling in focal dermal hypoplasia","volume":"39","author":"Paller","year":"2007","journal-title":"Nat Genet"},{"key":"10.1111\/bjd.15001-BIB0041|bjd15001-cit-0041","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1111\/j.1365-2133.2007.08141.x","article-title":"Severe linear form of granuloma annulare along Blaschko's lines preceding the onset of a classical form of granuloma annulare in a child","volume":"157","author":"Morice-Picard","year":"2007","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.15001-BIB0042|bjd15001-cit-0042","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1002\/art.21948","article-title":"Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts","volume":"54","author":"Wang","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1111\/bjd.15001-BIB0043|bjd15001-cit-0043","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1073\/pnas.062010399","article-title":"Deficient Smad7 expression: a putative molecular defect in scleroderma","volume":"99","author":"Dong","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/bjd.15001-BIB0044|bjd15001-cit-0044","first-page":"47","article-title":"The global microRNA profile of systemic sclerosis whole skin\/dermal fibroblasts and the role of the XQ26.3 miRNA cluster as a TGFB pathway positive feedback mechanism","volume":"1","author":"Salazar","year":"2016","journal-title":"J Scleroderma Related Disord"},{"key":"10.1111\/bjd.15001-BIB0045|bjd15001-cit-0045","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1164\/rccm.200911-1698OC","article-title":"Inhibition and role of let-7d in idiopathic pulmonary fibrosis","volume":"182","author":"Pandit","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1111\/bjd.15001-BIB0046|bjd15001-cit-0046","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/nrrheum.2011.149","article-title":"Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities","volume":"8","author":"Bhattacharyya","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"10.1111\/bjd.15001-BIB0047|bjd15001-cit-0047","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1093\/rheumatology\/ket254","article-title":"Alteration of circulating miRNAs in SSc: miR-30b regulates the expression of PDGF receptor beta","volume":"52","author":"Tanaka","year":"2013","journal-title":"Rheumatology"},{"key":"10.1111\/bjd.15001-BIB0048|bjd15001-cit-0048","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00403-012-1287-4","article-title":"microRNA-7 down-regulation mediates excessive collagen expression in localized scleroderma","volume":"305","author":"Etoh","year":"2013","journal-title":"Arch Dermatol Res"},{"key":"10.1111\/bjd.15001-BIB0049|bjd15001-cit-0049","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.4049\/jimmunol.1200822","article-title":"The downregulation of microRNA let-7a contributes to the excessive expression of type I collagen in systemic and localized scleroderma","volume":"190","author":"Makino","year":"2013","journal-title":"J Immunol"},{"key":"10.1111\/bjd.15001-BIB0050|bjd15001-cit-0050","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1684\/ejd.2014.2384","article-title":"Down-regulation of microRNA-196a in the sera and involved skin of localized scleroderma patients","volume":"24","author":"Makino","year":"2014","journal-title":"Eur J Dermatol"},{"key":"10.1111\/bjd.15001-BIB0051|bjd15001-cit-0051","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jaad.2008.09.023","article-title":"\u2018Borrelia-associated early-onset morphea\u2019: a particular type of scleroderma in childhood and adolescence with high tire antinuclear antibodies? Results of a cohort analysis and presentation of three cases","volume":"60","author":"Prinz","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.15001-BIB0052|bjd15001-cit-0052","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jaad.2010.05.046","article-title":"Update on morphea: part II. Outcome measures and treatment","volume":"64","author":"Fett","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.15001-BIB0053|bjd15001-cit-0053","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jaad.2010.05.045","article-title":"Update on morphea: part I. Epidemiology, clinical presentation, and pathogenesis","volume":"64","author":"Fett","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.15001-BIB0054|bjd15001-cit-0054","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jaad.2014.04.009","article-title":"The role of skin trauma in the distribution of morphea lesions: a cross-sectional survey of the Morphea in Adults and Children cohort IV","volume":"71","author":"Grabell","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.15001-BIB0055|bjd15001-cit-0055","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3346\/jkms.1995.10.2.152","article-title":"Trauma-induced isomorphic lesions in morphea - a brief case report","volume":"10","author":"Ahn","year":"1995","journal-title":"J Korean Med Sci"},{"key":"10.1111\/bjd.15001-BIB0056|bjd15001-cit-0056","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1017\/erm.2013.10","article-title":"Role of Toll-like receptors in systemic sclerosis","volume":"15","author":"Ciechomska","year":"2013","journal-title":"Exp Rev Mol Med"},{"key":"10.1111\/bjd.15001-BIB0057|bjd15001-cit-0057","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1046\/j.1365-2230.1998.00324.x","article-title":"Generalized morphoea after antitetanus vaccination","volume":"23","author":"Drago","year":"1998","journal-title":"Clin Exp Dermatol"},{"key":"10.1111\/bjd.15001-BIB0058|bjd15001-cit-0058","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1525-1470.2006.00289.x","article-title":"Deep morphea after vaccination in two young children","volume":"23","author":"Torrelo","year":"2006","journal-title":"Pediatr Dermatol"},{"key":"10.1111\/bjd.15001-BIB0059|bjd15001-cit-0059","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.jaad.2009.02.047","article-title":"Morphea profunda in a young infant after hepatitis B vaccination","volume":"63","author":"Benmously Mlika","year":"2010","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.15001-BIB0060|bjd15001-cit-0060","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1525-1470.2011.01548.x","article-title":"Postvaccination morphea profunda in a child","volume":"29","author":"Khaled","year":"2012","journal-title":"Pediatr Dermatol"},{"key":"10.1111\/bjd.15001-BIB0061|bjd15001-cit-0061","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ad.2014.06.012","article-title":"Pediatric generalized morphea that developed at a BCG vaccination site","volume":"106","author":"Matsumoto","year":"2015","journal-title":"Actas Dermosifiliograf"},{"key":"10.1111\/bjd.15001-BIB0062|bjd15001-cit-0062","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1365-4362.1995.tb01569.x","article-title":"Morphea-like reaction from vitamin K1","volume":"34","author":"Morell","year":"1995","journal-title":"Int J Dermatol"},{"key":"10.1111\/bjd.15001-BIB0063|bjd15001-cit-0063","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0190-9622(98)70574-2","article-title":"Vitamin K1-induced localized scleroderma (morphea) with linear deposition of IgA in the basement membrane zone","volume":"38","author":"Alonso-Llamazares","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.15001-BIB0064|bjd15001-cit-0064","first-page":"1252","article-title":"Vitamin B12-associated localized scleroderma and its treatment","volume":"30","author":"Ho","year":"2004","journal-title":"Dermatol Surg"},{"key":"10.1111\/bjd.15001-BIB0065|bjd15001-cit-0065","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1684\/ejd.2014.2303","article-title":"Morphea as a sign of autoimmune syndrome induced by adjuvants (ASIA)","volume":"24","author":"Frances","year":"2014","journal-title":"Eur J Dermatol"},{"key":"10.1111\/bjd.15001-BIB0066|bjd15001-cit-0066","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1111\/j.1365-2230.2009.03717.x","article-title":"Postirradiation linear morphoea","volume":"35","author":"Akay","year":"2010","journal-title":"Clin Exp Dermatol"},{"key":"10.1111\/bjd.15001-BIB0067|bjd15001-cit-0067","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1046\/j.1440-0960.1999.00330.x","article-title":"Radiation-induced localized scleroderma in breast cancer patients","volume":"40","author":"Bleasel","year":"1999","journal-title":"Australas J Dermatol"},{"key":"10.1111\/bjd.15001-BIB0068|bjd15001-cit-0068","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1748-717X-3-40","article-title":"Radiation-induced skin injury in the animal model of scleroderma: implications for post-radiotherapy fibrosis","volume":"3","author":"Kumar","year":"2008","journal-title":"Radiat Oncol"},{"key":"10.1111\/bjd.15001-BIB0069|bjd15001-cit-0069","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0140-6736(85)90329-0","article-title":"Is localised scleroderma a Borrelia infection?","volume":"2","author":"Aberer","year":"1985","journal-title":"Lancet"},{"key":"10.1111\/bjd.15001-BIB0070|bjd15001-cit-0070","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/00000372-199108000-00003","article-title":"A clinical, histological, and immunohistochemical comparison of acrodermatitis chronica atrophicans and morphea","volume":"13","author":"Aberer","year":"1991","journal-title":"Am J Dermatopathol"},{"key":"10.1111\/bjd.15001-BIB0071|bjd15001-cit-0071","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/0190-9622(95)91281-9","article-title":"Borrelia burgdorferi DNA is undetectable by polymerase chain reaction in skin lesions of morphea, scleroderma, or lichen sclerosus et atrophicus of patients from North America","volume":"33","author":"Dillon","year":"1995","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.15001-BIB0072|bjd15001-cit-0072","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1136\/mp.55.6.374","article-title":"Morphoea and Borrelia burgdorferi: results from the Scottish Highlands in the context of the world literature","volume":"55","author":"Goodlad","year":"2002","journal-title":"Mol Pathol"},{"key":"10.1111\/bjd.15001-BIB0073|bjd15001-cit-0073","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1046\/j.1365-2133.2000.03407.x","article-title":"Is morphoea caused by Borrelia burgdorferi?","volume":"142","author":"Weide","year":"2000","journal-title":"A review. Br J Dermatol"},{"key":"10.1111\/bjd.15001-BIB0074|bjd15001-cit-0074","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1111\/j.1365-2133.2007.08235.x","article-title":"Morphoea: a manifestation of infection with Borrelia species?","volume":"157","author":"Eisendle","year":"2007","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.15001-BIB0075|bjd15001-cit-0075","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1001\/archdermatol.2009.131","article-title":"Anti-double-stranded DNA-positive unilateral generalized morphea in an adult, possibly exacerbated by ibuprofen","volume":"145","author":"Kraigher","year":"2009","journal-title":"Arch Dermatol"},{"key":"10.1111\/bjd.15001-BIB0076|bjd15001-cit-0076","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.4081\/dr.2010.e9","article-title":"Taxane-induced morphea in a patient with CREST syndrome","volume":"2","author":"Bouchard","year":"2010","journal-title":"Dermatol Rep"},{"key":"10.1111\/bjd.15001-BIB0077|bjd15001-cit-0077","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1067\/mjd.2003.30","article-title":"Scleroderma-like cutaneous lesions induced by paclitaxel: a case study","volume":"48","author":"Kupfer","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.15001-BIB0078|bjd15001-cit-0078","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jaad.2008.03.009","article-title":"Drug-induced morphea: report of a case induced by balicatib and review of the literature","volume":"59","author":"Peroni","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.15001-BIB0079|bjd15001-cit-0079","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1016\/j.jaad.2010.11.033","article-title":"Morphea-like skin reactions in patients treated with the cathepsin K inhibitor balicatib","volume":"66","author":"Runger","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.15001-BIB0080|bjd15001-cit-0080","first-page":"573","article-title":"Drug induction in connective tissue diseases","volume":"149","author":"Verdelli","year":"2014","journal-title":"G Ital Dermatol Venereol"},{"key":"10.1111\/bjd.15001-BIB0081|bjd15001-cit-0081","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.1016\/j.jaad.2010.02.036","article-title":"Pseudoscleroderma possibly induced by intravesical instillation of mitomycin C","volume":"63","author":"Calistru","year":"2010","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.15001-BIB0082|bjd15001-cit-0082","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/sj.jidsp.5640205","article-title":"The roles of keratinocyte-derived cytokines in the epidermis and their possible responses to UVA-irradiation","volume":"4","author":"Kondo","year":"1999","journal-title":"J Invest Dermatol Symp Proc"},{"key":"10.1111\/bjd.15001-BIB0083|bjd15001-cit-0083","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1160\/TH03-11-0669","article-title":"Dissecting the roles of endothelin, TGF-beta and GM-CSF on myofibroblast differentiation by keratinocytes","volume":"92","author":"Shephard","year":"2004","journal-title":"Thromb Haemost"},{"key":"10.1111\/bjd.15001-BIB0084|bjd15001-cit-0084","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/jid.2008.253","article-title":"Keratinocyte-conditioned media regulate collagen expression in dermal fibroblasts","volume":"129","author":"Ghaffari","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.15001-BIB0085|bjd15001-cit-0085","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1524-475X.2010.00605.x","article-title":"Regulation of fibroblast gene expression by keratinocytes in organotypic skin culture provides possible mechanisms for the antifibrotic effect of reepithelialization","volume":"18","author":"Koskela","year":"2010","journal-title":"Wound Repair Regen"},{"key":"10.1111\/bjd.15001-BIB0086|bjd15001-cit-0086","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/rheumatology\/ken370","article-title":"Proteomic analysis of scleroderma lesional skin reveals activated wound healing phenotype of epidermal cell layer","volume":"47","author":"Aden","year":"2008","journal-title":"Rheumatology"},{"key":"10.1111\/bjd.15001-BIB0087|bjd15001-cit-0087","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1038\/jid.2014.253","article-title":"Abnormally differentiating keratinocytes in the epidermis of systemic sclerosis patients show enhanced secretion of CCN2 and S100A9","volume":"134","author":"Nikitorowicz-Buniak","year":"2014","journal-title":"J Invest Dermatol"},{"issue":"Suppl. 10","key":"10.1111\/bjd.15001-BIB0088|bjd15001-cit-0088","article-title":"Scleroderma keratinocytes promote fibroblast activation independent of TGFB","volume":"67","author":"McCoy","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.1111\/bjd.15001-BIB0089|bjd15001-cit-0089","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/jidsymp.2011.1","article-title":"The role of chronic inflammation in cutaneous fibrosis: fibroblast growth factor receptor deficiency in keratinocytes as an example","volume":"15","author":"Meyer","year":"2011","journal-title":"J Invest Dermatol Symp Proc"},{"key":"10.1111\/bjd.15001-BIB0090|bjd15001-cit-0090","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/1523-1747.ep12345771","article-title":"Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders","volume":"106","author":"Igarashi","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.15001-BIB0091|bjd15001-cit-0091","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1159\/000087015","article-title":"Nodular scleroderma: increased expression of connective tissue growth factor","volume":"211","author":"Yamamoto","year":"2005","journal-title":"Dermatology"},{"key":"10.1111\/bjd.15001-BIB0092|bjd15001-cit-0092","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1369\/0022155410397999","article-title":"Spatial and temporal localization of the melanocortin 1 receptor and its ligand alpha-melanocyte-stimulating hormone during cutaneous wound repair","volume":"59","author":"Muffley","year":"2011","journal-title":"J Histochem Cytochem"},{"key":"10.1111\/bjd.15001-BIB0093|bjd15001-cit-0093","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1210\/er.2007-0027","article-title":"Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in\u00a0vitro and in\u00a0vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases","volume":"29","author":"Brzoska","year":"2008","journal-title":"Endocr Rev"},{"issue":"Suppl. 4","key":"10.1111\/bjd.15001-BIB0094|bjd15001-cit-0094","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1600-0625.2004.00256.x","article-title":"Melanocortins in fibroblast biology - current update and future perspective for dermatology","volume":"13","author":"Bohm","year":"2004","journal-title":"Exp Dermatol"},{"key":"10.1111\/bjd.15001-BIB0095|bjd15001-cit-0095","doi-asserted-by":"crossref","first-page":"6959","DOI":"10.1074\/jbc.M312549200","article-title":"Collagen metabolism is a novel target of the neuropeptide alpha-melanocyte-stimulating hormone","volume":"279","author":"Bohm","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1111\/bjd.15001-BIB0096|bjd15001-cit-0096","first-page":"61","article-title":"Non-pigmentary actions of alpha-melanocyte-stimulating hormone - lessons from the cutaneous melanocortin system","volume":"52","author":"Bohm","year":"2006","journal-title":"Cell Mol Biol"},{"key":"10.1111\/bjd.15001-BIB0097|bjd15001-cit-0097","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/exd.12310","article-title":"Melanocortin 1 receptor and skin pathophysiology: beyond colour, much more than meets the eye","volume":"23","author":"Garcia-Borron","year":"2014","journal-title":"Exp Dermatol"},{"key":"10.1111\/bjd.15001-BIB0098|bjd15001-cit-0098","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1002\/1529-0131(199912)42:12<2656::AID-ANR22>3.0.CO;2-N","article-title":"Autoantibodies to the extracellular matrix microfibrillar protein, fibrillin 1, in patients with localized scleroderma","volume":"42","author":"Arnett","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1111\/bjd.15001-BIB0099|bjd15001-cit-0099","doi-asserted-by":"crossref","first-page":"23ra20","DOI":"10.1126\/scitranslmed.3000488","article-title":"Mutations in fibrillin-1 cause congenital scleroderma: stiff skin syndrome","volume":"2","author":"Loeys","year":"2010","journal-title":"Sci Transl Med"},{"key":"10.1111\/bjd.15001-BIB0100|bjd15001-cit-0100","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1542\/peds.47.2.360","article-title":"Stiff skin syndrome","volume":"47","author":"Esterly","year":"1971","journal-title":"Pediatrics"},{"key":"10.1111\/bjd.15001-BIB0101|bjd15001-cit-0101","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/1529-0131(200104)44:4<893::AID-ANR146>3.0.CO;2-3","article-title":"Association of fibrillin 1 single-nucleotide polymorphism haplotypes with systemic sclerosis in Choctaw and Japanese populations","volume":"44","author":"Tan","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1111\/bjd.15001-BIB0102|bjd15001-cit-0102","first-page":"28","article-title":"Inhibition of phosphodiesterase 4 (PDE4) reduces dermal fibrosis by interfering with the release of profibrotic cytokines from M2-macrophages","volume":"1","author":"Maier","year":"2016","journal-title":"J Scleroderma Relat Disord"},{"key":"10.1111\/bjd.15001-BIB0103|bjd15001-cit-0103","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/path.853","article-title":"Keratinocyte-derived growth factors play a role in the formation of hypertrophic scars","volume":"194","author":"Niessen","year":"2001","journal-title":"J Pathol"},{"key":"10.1111\/bjd.15001-BIB0104|bjd15001-cit-0104","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/j.1523-1747.2003.12572.x","article-title":"Keratinocytes promote proliferation and inhibit apoptosis of the underlying fibroblasts: an important role in the pathogenesis of keloid","volume":"121","author":"Funayama","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.15001-BIB0105|bjd15001-cit-0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.1737","article-title":"Epidermis promotes dermal fibrosis: role in the pathogenesis of hypertrophic scars","volume":"206","author":"Bellemare","year":"2005","journal-title":"J Pathol"},{"issue":"Suppl. 1","key":"10.1111\/bjd.15001-BIB0106|bjd15001-cit-0106","doi-asserted-by":"crossref","first-page":"s16","DOI":"10.1111\/j.1524-475X.2011.00709.x","article-title":"The role of the epidermis and the mechanism of action of occlusive dressings in scarring","volume":"19","author":"Mustoe","year":"2011","journal-title":"Wound Repair Regener"},{"key":"10.1111\/bjd.15001-BIB0107|bjd15001-cit-0107","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.burns.2011.09.001","article-title":"Enhanced secretion of TIMP-1 by human hypertrophic scar keratinocytes could contribute to fibrosis","volume":"38","author":"Simon","year":"2012","journal-title":"Burns"},{"key":"10.1111\/bjd.15001-BIB0108|bjd15001-cit-0108","doi-asserted-by":"crossref","first-page":"12877","DOI":"10.1073\/pnas.162488599","article-title":"Diversity, topographic differentiation, and positional memory in human fibroblasts","volume":"99","author":"Chang","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/bjd.15001-BIB0109|bjd15001-cit-0109","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1007\/s10753-012-9491-0","article-title":"Effect of resveratrol on treatment of bleomycin-induced pulmonary fibrosis in rats","volume":"35","author":"Akgedik","year":"2012","journal-title":"Inflammation"},{"key":"10.1111\/bjd.15001-BIB0110|bjd15001-cit-0110","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1136\/annrheumdis-2011-200883","article-title":"Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis","volume":"71","author":"Horn","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1111\/bjd.15001-BIB0111|bjd15001-cit-0111","first-page":"136","article-title":"Notch induces myofibroblast differentiation of alveolar epithelial cells via transforming growth factor-{beta}-Smad3 pathway","volume":"45","author":"Aoyagi-Ikeda","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1111\/bjd.15001-BIB0112|bjd15001-cit-0112","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1002\/art.27626","article-title":"Targeting ADAM-17\/notch signaling abrogates the development of systemic sclerosis in a murine model","volume":"62","author":"Kavian","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1111\/bjd.15001-BIB0113|bjd15001-cit-0113","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/art.30254","article-title":"Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis","volume":"63","author":"Dees","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1111\/bjd.15001-BIB0114|bjd15001-cit-0114","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/ar4230","article-title":"Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells","volume":"15","author":"Gilbane","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"10.1111\/bjd.15001-BIB0115|bjd15001-cit-0115","doi-asserted-by":"crossref","first-page":"e19809","DOI":"10.1371\/journal.pone.0019809","article-title":"Wnt3a induces myofibroblast differentiation by upregulating TGF-beta signaling through SMAD2 in a beta-catenin-dependent manner","volume":"6","author":"Carthy","year":"2011","journal-title":"PLOS ONE"},{"key":"10.1111\/bjd.15001-BIB0116|bjd15001-cit-0116","doi-asserted-by":"crossref","first-page":"8196","DOI":"10.1074\/jbc.M109.025684","article-title":"SPARC suppresses apoptosis of idiopathic pulmonary fibrosis fibroblasts through constitutive activation of beta-catenin","volume":"285","author":"Chang","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1111\/bjd.15001-BIB0117|bjd15001-cit-0117","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nchembio.453","article-title":"Small-molecule inhibition of Wnt signaling through activation of casein kinase 1alpha","volume":"6","author":"Thorne","year":"2010","journal-title":"Nat Chem Biol"},{"key":"10.1111\/bjd.15001-BIB0118|bjd15001-cit-0118","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1002\/art.30312","article-title":"Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma?","volume":"63","author":"Wei","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1111\/bjd.15001-BIB0119|bjd15001-cit-0119","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/path.4481","article-title":"Sustained beta-catenin activity in dermal fibroblasts promotes fibrosis by up-regulating expression of extracellular matrix protein-coding genes","volume":"235","author":"Hamburg-Shields","year":"2015","journal-title":"J Pathol"},{"key":"10.1111\/bjd.15001-BIB0120|bjd15001-cit-0120","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrg1427","article-title":"WNT and beta-catenin signalling: diseases and therapies","volume":"5","author":"Moon","year":"2004","journal-title":"Nat Rev Genet"},{"key":"10.1111\/bjd.15001-BIB0121|bjd15001-cit-0121","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cellsig.2007.10.031","article-title":"The first five years of the Wnt targetome","volume":"20","author":"Vlad","year":"2008","journal-title":"Cell Signal"},{"key":"10.1111\/bjd.15001-BIB0122|bjd15001-cit-0122","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1165\/rcmb.2008-0485TR","article-title":"WNT signaling in lung disease: a failure or a regeneration signal?","volume":"42","author":"Konigshoff","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1111\/bjd.15001-BIB0123|bjd15001-cit-0123","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/sj.jid.5701101","article-title":"Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis","volume":"128","author":"Bayle","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.15001-BIB0124|bjd15001-cit-0124","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S0002-9440(10)64282-4","article-title":"Aberrant Wnt\/beta-catenin pathway activation in idiopathic pulmonary fibrosis","volume":"162","author":"Chilosi","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1111\/bjd.15001-BIB0125|bjd15001-cit-0125","first-page":"772","article-title":"WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis","volume":"119","author":"Konigshoff","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1111\/bjd.15001-BIB0126|bjd15001-cit-0126","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1165\/rcmb.2010-0113OC","article-title":"Nuclear beta-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation","volume":"45","author":"Lam","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1111\/bjd.15001-BIB0127|bjd15001-cit-0127","first-page":"29","article-title":"Wnt\/PCP-signaling as a B-catenin-independent pathway to promote fibroblast activation in SSc","volume":"1","author":"Chen","year":"2016","journal-title":"J Scleroderma Relat Disord"},{"key":"10.1111\/bjd.15001-BIB0128|bjd15001-cit-0128","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1038\/jid.2010.200","article-title":"Poly(I:C) drives type I IFN- and TGFbeta-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis","volume":"130","author":"Farina","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.15001-BIB0129|bjd15001-cit-0129","doi-asserted-by":"crossref","first-page":"e267","DOI":"10.1016\/j.lpm.2014.08.001","article-title":"Pathophysiology of systemic sclerosis: state of the art in 2014","volume":"43","author":"Dumoitier","year":"2014","journal-title":"Presse Med"},{"key":"10.1111\/bjd.15001-BIB0130|bjd15001-cit-0130","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1016\/j.ajpath.2013.02.016","article-title":"The c-Rel subunit of NF-kappaB regulates epidermal homeostasis and promotes skin fibrosis in mice","volume":"182","author":"Fullard","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1111\/bjd.15001-BIB0131|bjd15001-cit-0131","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1136\/ard.2010.134858","article-title":"NFkappaB activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of nephrogenic systemic fibrosis","volume":"69","author":"Del Galdo","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1111\/bjd.15001-BIB0132|bjd15001-cit-0132","first-page":"5","article-title":"Expression of NLRP3 inflammasome, cytokines and vascular mediators in the skin of systemic sclerosis patients","volume":"17","author":"Martinez-Godinez","year":"2015","journal-title":"Israel Med Assoc J"},{"key":"10.1111\/bjd.15001-BIB0133|bjd15001-cit-0133","first-page":"23","article-title":"[Changes of cytokines secreted by human oral mucosa keratinocytes from oral submucous fibrosis in\u00a0vitro]","volume":"18","author":"Feng","year":"2000","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"key":"10.1111\/bjd.15001-BIB0134|bjd15001-cit-0134","doi-asserted-by":"crossref","first-page":"e23082","DOI":"10.1371\/journal.pone.0023082","article-title":"Egr-1 induces a profibrotic injury\/repair gene program associated with systemic sclerosis","volume":"6","author":"Bhattacharyya","year":"2011","journal-title":"PLOS ONE"},{"key":"10.1111\/bjd.15001-BIB0135|bjd15001-cit-0135","first-page":"831","article-title":"Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung disease","volume":"151","author":"Abraham","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1111\/bjd.15001-BIB0136|bjd15001-cit-0136","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1002\/art.23134","article-title":"Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts","volume":"56","author":"Shi-wen","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1111\/bjd.15001-BIB0137|bjd15001-cit-0137","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cyto.2011.04.001","article-title":"Cytokine profiles in localized scleroderma and relationship to clinical features","volume":"55","author":"Kurzinski","year":"2011","journal-title":"Cytokine"},{"key":"10.1111\/bjd.15001-BIB0138|bjd15001-cit-0138","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF01262331","article-title":"Demonstration of interleukin-2, interleukin-4 and interleukin-6 in sera from patients with localized scleroderma","volume":"287","author":"Ihn","year":"1995","journal-title":"Arch Dermatol Res"},{"key":"10.1111\/bjd.15001-BIB0139|bjd15001-cit-0139","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000071783","article-title":"Serum levels of tumor necrosis factor and interleukin-13 are elevated in patients with localized scleroderma","volume":"207","author":"Hasegawa","year":"2003","journal-title":"Dermatology"},{"key":"10.1111\/bjd.15001-BIB0140|bjd15001-cit-0140","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1001\/archderm.1992.01680130051005","article-title":"Treatment of systemic sclerosis with extracorporeal photochemotherapy. Results of a multicenter trial","volume":"128","author":"Rook","year":"1992","journal-title":"Arch Dermatol"},{"key":"10.1111\/bjd.15001-BIB0141|bjd15001-cit-0141","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.3899\/jrheum.080098","article-title":"Serum autoantibodies and their clinical associations in patients with childhood- and adult-onset linear scleroderma. A single-center study","volume":"35","author":"Arkachaisri","year":"2008","journal-title":"J Rheumatol"},{"key":"10.1111\/bjd.15001-BIB0142|bjd15001-cit-0142","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/S0022-3565(24)35380-7","article-title":"Interleukin-13 modulates collagen homeostasis in human skin and keloid fibroblasts","volume":"292","author":"Oriente","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/bjd.15001-BIB0143|bjd15001-cit-0143","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1365-2133.1996.tb06313.x","article-title":"Clinical significance of serum levels of soluble interleukin-2 receptor in patients with localized scleroderma","volume":"134","author":"Ihn","year":"1996","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.15001-BIB0144|bjd15001-cit-0144","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.semarthrit.2015.06.006","article-title":"Peripheral blood cytokine and chemokine profiles in juvenile localized scleroderma: T-helper cell-associated cytokine profiles","volume":"45","author":"Torok","year":"2015","journal-title":"Semin Arthritis Rheum"},{"key":"10.1111\/bjd.15001-BIB0145|bjd15001-cit-0145","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1097\/BOR.0b013e32835896ce","article-title":"Morphea and other localized forms of scleroderma","volume":"24","author":"Vasquez","year":"2012","journal-title":"Curr Opin Rheumatol"},{"key":"10.1111\/bjd.15001-BIB0146|bjd15001-cit-0146","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/1523-1747.ep12331158","article-title":"Interleukin-1-induced growth factor expression in postmitotic and resting fibroblasts","volume":"107","author":"Maas-Szabowski","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.15001-BIB0147|bjd15001-cit-0147","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1038\/jid.2010.120","article-title":"Epithelial cells promote fibroblast activation via IL-1alpha in systemic sclerosis","volume":"130","author":"Aden","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.15001-BIB0148|bjd15001-cit-0148","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/1523-1747.ep12286455","article-title":"Scleroderma fibroblasts show increased responsiveness to endothelial cell-derived IL-1 and bFGF","volume":"108","author":"Denton","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.15001-BIB0149|bjd15001-cit-0149","doi-asserted-by":"crossref","first-page":"e105008","DOI":"10.1371\/journal.pone.0105008","article-title":"High IL-17E and low IL-17C dermal expression identifies a fibrosis-specific motif common to morphea and systemic sclerosis","volume":"9","author":"Lonati","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1111\/bjd.15001-BIB0150|bjd15001-cit-0150","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1365-2230.2012.04385.x","article-title":"Subcutaneous administration of polymerized type I collagen downregulates interleukin (IL)-17A, IL- 22 and transforming growth factor-beta1 expression, and increases Foxp3-expressing cells in localized scleroderma","volume":"37","author":"Furuzawa-Carballeda","year":"2012","journal-title":"Clin Exp Dermatol"},{"key":"10.1111\/bjd.15001-BIB0151|bjd15001-cit-0151","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/art.1780370218","article-title":"Immunocytochemical localization and serologic detection of transforming growth factor beta 1. Association with type I procollagen and inflammatory cell markers in diffuse and limited systemic sclerosis, morphea, and Raynaud's phenomenon","volume":"37","author":"Higley","year":"1994","journal-title":"Arthritis Rheum"},{"key":"10.1111\/bjd.15001-BIB0152|bjd15001-cit-0152","first-page":"2558","article-title":"Upregulated expression of transforming growth factor-beta receptors in dermal fibroblasts of skin sections from patients with systemic sclerosis","volume":"29","author":"Kubo","year":"2002","journal-title":"J Rheumatol"},{"key":"10.1111\/bjd.15001-BIB0153|bjd15001-cit-0153","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/art.23379","article-title":"Fibroblast-specific perturbation of transforming growth factor beta signaling provides insight into potential pathogenic mechanisms of scleroderma-associated lung fibrosis: exaggerated response to alveolar epithelial injury in a novel mouse model","volume":"58","author":"Hoyles","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1111\/bjd.15001-BIB0154|bjd15001-cit-0154","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/(SICI)1097-4652(199910)181:1<153::AID-JCP16>3.0.CO;2-K","article-title":"Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: a mouse fibrosis model","volume":"181","author":"Mori","year":"1999","journal-title":"J Cell Physiol"},{"key":"10.1111\/bjd.15001-BIB0155|bjd15001-cit-0155","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.0959-9673.2004.00377.x","article-title":"Smad3 as a mediator of the fibrotic response","volume":"85","author":"Flanders","year":"2004","journal-title":"Int J Exp Pathol"},{"key":"10.1111\/bjd.15001-BIB0156|bjd15001-cit-0156","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1006\/excr.2000.4972","article-title":"Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis","volume":"259","author":"Shi-wen","year":"2000","journal-title":"Exp Cell Res"},{"key":"10.1111\/bjd.15001-BIB0157|bjd15001-cit-0157","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/00002281-200111000-00010","article-title":"Transforming growth factor-beta and connective tissue growth factor: key cytokines in scleroderma pathogenesis","volume":"13","author":"Denton","year":"2001","journal-title":"Curr Opin Rheumatol"},{"key":"10.1111\/bjd.15001-BIB0158|bjd15001-cit-0158","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1136\/annrheumdis-2011-200837","article-title":"Increased serum levels and tissue expression of matrix metalloproteinase-12 in patients with systemic sclerosis: correlation with severity of skin and pulmonary fibrosis and vascular damage","volume":"71","author":"Manetti","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1111\/bjd.15001-BIB0159|bjd15001-cit-0159","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.3899\/jrheum.100237","article-title":"Association of a functional polymorphism in the matrix metalloproteinase-12 promoter region with systemic sclerosis in an Italian population","volume":"37","author":"Manetti","year":"2010","journal-title":"J Rheumatol"},{"key":"10.1111\/bjd.15001-BIB0160|bjd15001-cit-0160","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1038\/jid.2014.173","article-title":"Upregulation of MMP12 and its activity by UVA1 in human skin: potential implications for photoaging","volume":"134","author":"Tewari","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.15001-BIB0161|bjd15001-cit-0161","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-0625.2006.00485.x","article-title":"Elevated serum BAFF levels in patients with localized scleroderma in contrast to other organ-specific autoimmune diseases","volume":"16","author":"Matsushita","year":"2007","journal-title":"Exp Dermatol"},{"key":"10.1111\/bjd.15001-BIB0162|bjd15001-cit-0162","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.autrev.2015.10.005","article-title":"Systemic sclerosis: new evidence re-enforces the role of B cells","volume":"15","author":"Sakkas","year":"2016","journal-title":"Autoimmun Rev"},{"key":"10.1111\/bjd.15001-BIB0163|bjd15001-cit-0163","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1465-9921-11-21","article-title":"Effects of PPAR gamma ligands on TGF-beta1-induced epithelial-mesenchymal transition in alveolar epithelial cells","volume":"11","author":"Tan","year":"2010","journal-title":"Respir Res"},{"key":"10.1111\/bjd.15001-BIB0164|bjd15001-cit-0164","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1158\/1535-7163.MCT-10-0570","article-title":"Peroxisome proliferator-activated receptor-gamma activation inhibits tumor metastasis by antagonizing Smad3-mediated epithelial-mesenchymal transition","volume":"9","author":"Reka","year":"2010","journal-title":"Mol Cancer Ther"},{"key":"10.1111\/bjd.15001-BIB0165|bjd15001-cit-0165","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.2353\/ajpath.2010.090048","article-title":"Epithelial to mesenchymal transition in human skin wound healing is induced by tumor necrosis factor-alpha through bone morphogenic protein-2","volume":"176","author":"Yan","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1111\/bjd.15001-BIB0166|bjd15001-cit-0166","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/exd.12452","article-title":"SMAD inhibition attenuates epithelial to mesenchymal transition by primary keratinocytes in\u00a0vitro","volume":"23","author":"O'Kane","year":"2014","journal-title":"Exp Dermatol"},{"key":"10.1111\/bjd.15001-BIB0167|bjd15001-cit-0167","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/1346-8138.12235","article-title":"Epithelial-mesenchymal transition of the eccrine glands is involved in skin fibrosis in morphea","volume":"40","author":"Takahashi","year":"2013","journal-title":"J Dermatol"},{"key":"10.1111\/bjd.15001-BIB0168|bjd15001-cit-0168","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11926-008-0031-8","article-title":"Circulating progenitor cells and scleroderma","volume":"10","author":"Gomer","year":"2008","journal-title":"Curr Rheumatol Rep"},{"key":"10.1111\/bjd.15001-BIB0169|bjd15001-cit-0169","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2177\/jsci.36.17","article-title":"[Roles of aberrant endothelial progenitor cells in pathogenesis of systemic sclerosis]","volume":"36","author":"Kuwana","year":"2013","journal-title":"Nihon Rinsho Men'eki Gakkai Kaishi"},{"key":"10.1111\/bjd.15001-BIB0170|bjd15001-cit-0170","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1101\/gad.1610508","article-title":"A dermal HOX transcriptional program regulates site-specific epidermal fate","volume":"22","author":"Rinn","year":"2008","journal-title":"Genes Dev"},{"key":"10.1111\/bjd.15001-BIB0171|bjd15001-cit-0171","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/sj.jid.5700986","article-title":"A systems biology approach to anatomic diversity of skin","volume":"128","author":"Rinn","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.15001-BIB0172|bjd15001-cit-0172","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1371\/journal.pgen.0020119","article-title":"Anatomic demarcation by positional variation in fibroblast gene expression programs","volume":"2","author":"Rinn","year":"2006","journal-title":"PLOS Genet"},{"key":"10.1111\/bjd.15001-BIB0173|bjd15001-cit-0173","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.1371\/journal.pbio.0020007","article-title":"Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds","volume":"2","author":"Chang","year":"2004","journal-title":"PLOS Biol"},{"key":"10.1111\/bjd.15001-BIB0174|bjd15001-cit-0174","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/jcp.24239","article-title":"HOX and TALE signatures specify human stromal stem cell populations from different sources","volume":"228","author":"Picchi","year":"2013","journal-title":"J Cell Physiol"},{"key":"10.1111\/bjd.15001-BIB0175|bjd15001-cit-0175","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.matbio.2006.12.002","article-title":"Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice","volume":"26","author":"Akiyama","year":"2007","journal-title":"Matrix Biol"},{"key":"10.1111\/bjd.15001-BIB0176|bjd15001-cit-0176","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1089\/scd.2007.0220","article-title":"Mesenchymal stem cells from different organs are characterized by distinct topographic Hox codes","volume":"17","author":"Ackema","year":"2008","journal-title":"Stem Cells Dev"},{"key":"10.1111\/bjd.15001-BIB0177|bjd15001-cit-0177","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0168-9525(03)00176-8","article-title":"Transcriptional mechanisms in osteoblast differentiation and bone formation","volume":"19","author":"Nakashima","year":"2003","journal-title":"Trends Genet"},{"key":"10.1111\/bjd.15001-BIB0178|bjd15001-cit-0178","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/ng0796-275","article-title":"Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene","volume":"13","author":"Zhao","year":"1996","journal-title":"Nat Genet"},{"key":"10.1111\/bjd.15001-BIB0179|bjd15001-cit-0179","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nrrheum.2013.46","article-title":"Targeted therapies for systemic sclerosis","volume":"9","author":"Denton","year":"2013","journal-title":"Nat Rev Rheumatol"},{"key":"10.1111\/bjd.15001-BIB0180|bjd15001-cit-0180","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1136\/ard.2004.027094","article-title":"Early T cell activation in the skin from patients with systemic sclerosis","volume":"64","author":"Kalogerou","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1111\/bjd.15001-BIB0181|bjd15001-cit-0181","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.clim.2011.01.013","article-title":"Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis","volume":"139","author":"Fenoglio","year":"2011","journal-title":"Clin Immunol"},{"key":"10.1111\/bjd.15001-BIB0182|bjd15001-cit-0182","first-page":"686","article-title":"Abatacept is a promising treatment for patients with disseminated morphea profunda: presentation of two cases","volume":"91","author":"Stausbol-Gron","year":"2011","journal-title":"Acta Dermatovenereol"},{"key":"10.1111\/bjd.15001-BIB0183|bjd15001-cit-0183","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3109\/03009742.2013.812238","article-title":"Abatacept induces clinical improvement in patients with severe systemic sclerosis","volume":"43","author":"Paoli","year":"2014","journal-title":"Scand J Rheumatol"},{"key":"10.1111\/bjd.15001-BIB0184|bjd15001-cit-0184","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1136\/annrheumdis-2012-202657","article-title":"Outcomes of patients with systemic sclerosis-associated polyarthritis and myopathy treated with tocilizumab or abatacept: a EUSTAR observational study","volume":"72","author":"Elhai","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"10.1111\/bjd.15001-BIB0185|bjd15001-cit-0185","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1001\/archdermatol.2010.120","article-title":"Treatment of recalcitrant generalized morphea with infliximab","volume":"146","author":"Diab","year":"2010","journal-title":"Arch Dermatol"},{"key":"10.1111\/bjd.15001-BIB0186|bjd15001-cit-0186","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1093\/rheumatology\/ken142","article-title":"Infliximab effective in steroid-dependent juvenile eosinophilic fasciitis","volume":"47","author":"Tzaribachev","year":"2008","journal-title":"Rheumatology"},{"key":"10.1111\/bjd.15001-BIB0187|bjd15001-cit-0187","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1093\/rheumatology\/keq062","article-title":"Infliximab may be effective in the treatment of steroid-resistant eosinophilic fasciitis: report of three cases","volume":"49","author":"Khanna","year":"2010","journal-title":"Rheumatology"},{"key":"10.1111\/bjd.15001-BIB0188|bjd15001-cit-0188","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.anai.2011.01.021","article-title":"Eosinophilic fasciitis mimicking angioedema and treatment response to infliximab in a pediatric patient","volume":"106","author":"Poliak","year":"2011","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1111\/bjd.15001-BIB0189|bjd15001-cit-0189","first-page":"59","article-title":"New side effect of TNF-alpha inhibitors: morphea","volume":"11","author":"Stewart","year":"2013","journal-title":"Skinmed"},{"key":"10.1111\/bjd.15001-BIB0190|bjd15001-cit-0190","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/ijd.12387","article-title":"Imatinib: a novel treatment approach for generalized morphea","volume":"53","author":"Coelho-Macias","year":"2014","journal-title":"Int J Dermatol"},{"key":"10.1111\/bjd.15001-BIB0191|bjd15001-cit-0191","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1111\/j.1525-1470.2012.01882.x","article-title":"Successful combination treatment of a patient with progressive juvenile localized scleroderma (morphea) using imatinib, corticosteroids, and methotrexate","volume":"30","author":"Inamo","year":"2013","journal-title":"Pediatr Dermatol"},{"key":"10.1111\/bjd.15001-BIB0192|bjd15001-cit-0192","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.1016\/j.jaad.2010.02.030","article-title":"Imatinib treatment of generalized localized scleroderma (morphea)","volume":"63","author":"Moinzadeh","year":"2010","journal-title":"J Am Acad Dermatol"},{"issue":"4 Suppl. 91","key":"10.1111\/bjd.15001-BIB0193|bjd15001-cit-0193","first-page":"S179","article-title":"Protective role of interleukin-6 in systemic sclerosis gastrointestinal tract involvement: case report and review of the literature","volume":"33","author":"Frech","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"10.1111\/bjd.15001-BIB0194|bjd15001-cit-0194","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/rheumatology\/keu435","article-title":"Treatment of systemic sclerosis with tocilizumab","volume":"54","author":"Fernandes das Neves","year":"2015","journal-title":"Rheumatology"},{"key":"10.1111\/bjd.15001-BIB0195|bjd15001-cit-0195","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3109\/14397595.2013.874749","article-title":"Expansion of range of joint motion following treatment of systemic sclerosis with tocilizumab","volume":"25","author":"Shima","year":"2015","journal-title":"Modern Rheumatol"},{"key":"10.1111\/bjd.15001-BIB0196|bjd15001-cit-0196","first-page":"31","article-title":"Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis","volume":"1","author":"Ruzehaji","year":"2016","journal-title":"J Scleroderma Relat Disord"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.15001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.15001","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/bjd.15001\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T13:13:24Z","timestamp":1749561204000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/177\/1\/34\/6601888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,30]]},"references-count":196,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"URL":"https:\/\/doi.org\/10.1111\/bjd.15001","archive":["Portico"],"relation":{},"ISSN":["0007-0963"],"issn-type":[{"value":"0007-0963","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5,30]]}}}