{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:58:54Z","timestamp":1790179134929,"version":"4.1.0"},"reference-count":95,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,6,11]],"date-time":"2017-06-11T00:00:00Z","timestamp":1497139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,6,11]],"date-time":"2017-06-11T00:00:00Z","timestamp":1497139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Dermatol"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1111\/bjd.15139","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T14:32:38Z","timestamp":1477405958000},"page":"63-71","source":"Crossref","is-referenced-by-count":46,"title":["The complex biology and contribution of<i>Staphylococcus aureus<\/i>in atopic dermatitis, current and future therapies"],"prefix":"10.1093","volume":"177","author":[{"given":"L.","family":"Hepburn","sequence":"first","affiliation":[{"name":"MedImmune; Milstein Building; Granta Park; Cambridge CB21 6GH U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.J.","family":"Hijnen","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht; Department of Dermatology; Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.R.","family":"Sellman","sequence":"additional","affiliation":[{"name":"MedImmune; Gaithersburg MD U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Mustelin","sequence":"additional","affiliation":[{"name":"MedImmune; Gaithersburg MD U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Sleeman","sequence":"additional","affiliation":[{"name":"MedImmune; Milstein Building; Granta Park; Cambridge CB21 6GH U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.D.","family":"May","sequence":"additional","affiliation":[{"name":"MedImmune; Milstein Building; Granta Park; Cambridge CB21 6GH U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Strickland","sequence":"additional","affiliation":[{"name":"MedImmune; Milstein Building; Granta Park; Cambridge CB21 6GH U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,6,11]]},"reference":[{"key":"10.1111\/bjd.15139-BIB0001|bjd15139-cit-0001","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0140-6736(03)12193-9","article-title":"Atopic dermatitis","volume":"361","author":"Leung","year":"2003","journal-title":"Lancet"},{"key":"10.1111\/bjd.15139-BIB0002|bjd15139-cit-0002","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1056\/NEJMra074081","article-title":"Atopic dermatitis","volume":"358","author":"Bieber","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1111\/bjd.15139-BIB0003|bjd15139-cit-0003","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1101\/gr.131029.111","article-title":"Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis","volume":"22","author":"Kong","year":"2012","journal-title":"Genome Res"},{"key":"10.1111\/bjd.15139-BIB0004|bjd15139-cit-0004","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1126\/science.1260144","article-title":"Dialogue between skin microbiota and immunity","volume":"346","author":"Belkaid","year":"2014","journal-title":"Science"},{"key":"10.1111\/bjd.15139-BIB0005|bjd15139-cit-0005","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1046\/j.1365-4362.1999.00686.x","article-title":"Comparative study of staphylococci from the skin of atopic dermatitis patients and from healthy subjects","volume":"38","author":"Higaki","year":"1999","journal-title":"Int J Dermatol"},{"key":"10.1111\/bjd.15139-BIB0006|bjd15139-cit-0006","doi-asserted-by":"crossref","first-page":"398","DOI":"10.5021\/ad.2015.27.4.398","article-title":"Antibiotic susceptibility of Staphylococcus aureus in atopic dermatitis: current prevalence of methicillin-resistant Staphylococcus aureus in Korea and treatment strategies","volume":"27","author":"Jung","year":"2015","journal-title":"Ann Dermatol"},{"key":"10.1111\/bjd.15139-BIB0007|bjd15139-cit-0007","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/ajd.12371","article-title":"Methicillin-resistant Staphylococcus aureus in children with atopic dermatitis from 1999 to 2014: a longitudinal study","volume":"57","author":"Chaptini","year":"2016","journal-title":"Australas J Dermatol"},{"key":"10.1111\/bjd.15139-BIB0008|bjd15139-cit-0008","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1056\/NEJMoa021481","article-title":"Endogenous antimicrobial peptides and skin infections in atopic dermatitis","volume":"347","author":"Ong","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1111\/bjd.15139-BIB0009|bjd15139-cit-0009","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/jid.2008.259","article-title":"Atopic dermatitis: a disease caused by innate immune defects?","volume":"129","author":"De Benedetto","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.15139-BIB0010|bjd15139-cit-0010","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1038\/ng.3424","article-title":"Multi-ethnic genome-wide association study of 21 000 cases and 95 000 controls identifies new risk loci for atopic dermatitis","volume":"47","author":"Paternoster","year":"2015","journal-title":"Nat Genet"},{"key":"10.1111\/bjd.15139-BIB0011|bjd15139-cit-0011","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nrmicro2537","article-title":"The skin microbiome","volume":"9","author":"Grice","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"10.1111\/bjd.15139-BIB0012|bjd15139-cit-0012","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3389\/fimmu.2013.00507","article-title":"Staphylococcus aureus colonization: modulation of host immune response and impact on human vaccine design","volume":"4","author":"Brown","year":"2014","journal-title":"Front Immunol"},{"key":"10.1111\/bjd.15139-BIB0013|bjd15139-cit-0013","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1046\/j.1365-2958.2003.03526.x","article-title":"Autoinduction and signal transduction in the regulation of staphylococcal virulence","volume":"48","author":"Novick","year":"2003","journal-title":"Mol Microbiol"},{"key":"10.1111\/bjd.15139-BIB0014|bjd15139-cit-0014","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.imlet.2013.01.004","article-title":"Staphylococcus aureus virulence factors in evasion from innate immune defenses in human and animal diseases","volume":"150","author":"Zecconi","year":"2013","journal-title":"Immunol Lett"},{"key":"10.1111\/bjd.15139-BIB0015|bjd15139-cit-0015","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1046\/j.1523-1747.1998.00293.x","article-title":"Role of Staphylococcus aureus surface-associated proteins in the attachment to cultured HaCaT keratinocytes in a new adhesion assay","volume":"111","author":"Mempel","year":"1998","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.15139-BIB0016|bjd15139-cit-0016","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrmicro3161","article-title":"Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus","volume":"12","author":"Foster","year":"2014","journal-title":"Nat Rev Microbiol"},{"key":"10.1111\/bjd.15139-BIB0017|bjd15139-cit-0017","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0966-842X(98)01400-0","article-title":"Surface protein adhesins of Staphylococcus aureus","volume":"6","author":"Foster","year":"1998","journal-title":"Trends Microbiol"},{"key":"10.1111\/bjd.15139-BIB0018|bjd15139-cit-0018","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1046\/j.0022-202x.2001.01331.x","article-title":"Preferential binding of Staphylococcus aureus to skin sites of Th2-mediated inflammation in a murine model","volume":"116","author":"Cho","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.15139-BIB0019|bjd15139-cit-0019","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1067\/mai.2001.117455","article-title":"Fibronectin and fibrinogen contribute to the enhanced binding of Staphylococcus aureus to atopic skin","volume":"108","author":"Cho","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/bjd.15139-BIB0020|bjd15139-cit-0020","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1172\/JCI116015","article-title":"Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4","volume":"90","author":"Postlethwaite","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1111\/bjd.15139-BIB0021|bjd15139-cit-0021","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/art.37706","article-title":"Interleukin-13-producing CD8+ T cells mediate dermal fibrosis in patients with systemic sclerosis","volume":"65","author":"Fuschiotti","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1111\/bjd.15139-BIB0022|bjd15139-cit-0022","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000098163","article-title":"A keratinocyte's course of life","volume":"20","author":"Houben","year":"2007","journal-title":"Skin Pharmacol Physiol"},{"key":"10.1111\/bjd.15139-BIB0023|bjd15139-cit-0023","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri2622","article-title":"Skin immune sentinels in health and disease","volume":"9","author":"Nestle","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1111\/bjd.15139-BIB0024|bjd15139-cit-0024","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1128\/CMR.18.3.521-540.2005","article-title":"Recognition of Staphylococcus aureus by the innate immune system","volume":"18","author":"Fournier","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"10.1111\/bjd.15139-BIB0025|bjd15139-cit-0025","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.imbio.2008.11.003","article-title":"C-type lectins and phagocytosis","volume":"214","author":"Kerrigan","year":"2009","journal-title":"Immunobiology"},{"key":"10.1111\/bjd.15139-BIB0026|bjd15139-cit-0026","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"10.1111\/bjd.15139-BIB0027|bjd15139-cit-0027","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.yadr.2008.09.004","article-title":"Toll-like receptors in skin","volume":"24","author":"Miller","year":"2008","journal-title":"Adv Dermatol"},{"key":"10.1111\/bjd.15139-BIB0028|bjd15139-cit-0028","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nri2873","article-title":"Sterile inflammation: sensing and reacting to damage","volume":"10","author":"Chen","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1111\/bjd.15139-BIB0029|bjd15139-cit-0029","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fcimb.2012.00043","article-title":"Intracellular Staphylococcus aureus: live-in and let die","volume":"2","author":"Fraunholz","year":"2012","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1111\/bjd.15139-BIB0030|bjd15139-cit-0030","doi-asserted-by":"crossref","first-page":"538546","DOI":"10.1155\/2014\/538546","article-title":"Nonprofessional phagocytic cell receptors involved in Staphylococcus aureus internalization","volume":"2014","author":"Alva-Murillo","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1111\/bjd.15139-BIB0031|bjd15139-cit-0031","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.tim.2008.11.005","article-title":"Staphylococcus aureus: new evidence for intracellular persistence","volume":"17","author":"Garzoni","year":"2009","journal-title":"Trends Microbiol"},{"key":"10.1111\/bjd.15139-BIB0032|bjd15139-cit-0032","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-065X.2008.00734.x","article-title":"Function of Nod-like receptors in microbial recognition and host defense","volume":"227","author":"Franchi","year":"2009","journal-title":"Immunol Rev"},{"key":"10.1111\/bjd.15139-BIB0033|bjd15139-cit-0033","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1074\/jbc.M511044200","article-title":"NOD2\/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2","volume":"281","author":"Voss","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1111\/bjd.15139-BIB0034|bjd15139-cit-0034","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1067\/mai.2003.1336","article-title":"Association between polymorphisms in caspase recruitment domain containing protein 15 and allergy in two German populations","volume":"111","author":"Kabesch","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/bjd.15139-BIB0035|bjd15139-cit-0035","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1600-0625.2007.00589.x","article-title":"Polymorphisms in NACHT-LRR (NLR) genes in atopic dermatitis","volume":"16","author":"Macaluso","year":"2007","journal-title":"Exp Dermatol"},{"key":"10.1111\/bjd.15139-BIB0036|bjd15139-cit-0036","doi-asserted-by":"crossref","first-page":"12873","DOI":"10.1073\/pnas.0904958106","article-title":"NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation","volume":"106","author":"Hruz","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/bjd.15139-BIB0037|bjd15139-cit-0037","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1128\/IAI.00940-08","article-title":"Critical role of NOD2 in regulating the immune response to Staphylococcus aureus","volume":"77","author":"Deshmukh","year":"2009","journal-title":"Infect Immun"},{"key":"10.1111\/bjd.15139-BIB0038|bjd15139-cit-0038","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/ni.2231","article-title":"Sensing and reacting to microbes through the inflammasomes","volume":"13","author":"Franchi","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1111\/bjd.15139-BIB0039|bjd15139-cit-0039","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nri2725","article-title":"NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?","volume":"10","author":"Tschopp","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1111\/bjd.15139-BIB0040|bjd15139-cit-0040","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1128\/CMR.13.1.16-34.2000","article-title":"Exotoxins of Staphylococcus aureus","volume":"13","author":"Dinges","year":"2000","journal-title":"Clin Microbiol Rev"},{"key":"10.1111\/bjd.15139-BIB0041|bjd15139-cit-0041","doi-asserted-by":"crossref","first-page":"13473","DOI":"10.1073\/pnas.1001815107","article-title":"Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury","volume":"107","author":"Wilke","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/bjd.15139-BIB0042|bjd15139-cit-0042","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.febslet.2008.12.028","article-title":"Elimination of a bacterial pore-forming toxin by sequential endocytosis and exocytosis","volume":"583","author":"Husmann","year":"2009","journal-title":"FEBS Lett"},{"key":"10.1111\/bjd.15139-BIB0043|bjd15139-cit-0043","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1038\/jid.2014.43","article-title":"Th2 cytokines increase Staphylococcus aureus alpha toxin-induced keratinocyte death through the signal transducer and activator of transcription 6 (STAT6)","volume":"134","author":"Brauweiler","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.15139-BIB0044|bjd15139-cit-0044","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fcimb.2012.00018","article-title":"Comparison of Staphylococcus aureus strains for ability to cause infective endocarditis and lethal sepsis in rabbits","volume":"2","author":"Spaulding","year":"2012","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1111\/bjd.15139-BIB0045|bjd15139-cit-0045","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1172\/JCI118263","article-title":"Evidence for a streptococcal superantigen-driven process in acute guttate psoriasis","volume":"96","author":"Leung","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1111\/bjd.15139-BIB0046|bjd15139-cit-0046","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1172\/JCI116711","article-title":"Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. Evidence for a new group of allergens","volume":"92","author":"Leung","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1111\/bjd.15139-BIB0047|bjd15139-cit-0047","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1099\/mic.0.26634-0","article-title":"The role and regulation of the extracellular proteases of Staphylococcus aureus","volume":"150","author":"Shaw","year":"2004","journal-title":"Microbiology"},{"key":"10.1111\/bjd.15139-BIB0048|bjd15139-cit-0048","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/intimm\/dxg062","article-title":"Persistent secretion of IL-18 in the skin contributes to IgE response in mice","volume":"15","author":"Nakano","year":"2003","journal-title":"Int Immunol"},{"key":"10.1111\/bjd.15139-BIB0049|bjd15139-cit-0049","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/1523-1747.ep12583377","article-title":"Staphylococcal toxins and protein A differentially induce cytotoxicity and release of tumor necrosis factor-alpha from human keratinocytes","volume":"107","author":"Ezepchuk","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.15139-BIB0050|bjd15139-cit-0050","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1600-0625.2010.01174.x","article-title":"TNF receptor I on human keratinocytes is a binding partner for staphylococcal protein A resulting in the activation of NF kappa B, AP-1, and downstream gene transcription","volume":"20","author":"Classen","year":"2011","journal-title":"Exp Dermatol"},{"key":"10.1111\/bjd.15139-BIB0051|bjd15139-cit-0051","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/j.1365-4632.2008.03924.x","article-title":"Keratinocytes treated with peptidoglycan from Staphylococcus aureus produce vascular endothelial growth factor, and its expression is amplified by the subsequent production of interleukin-13","volume":"48","author":"Ruiz-Gonzalez","year":"2009","journal-title":"Int J Dermatol"},{"key":"10.1111\/bjd.15139-BIB0052|bjd15139-cit-0052","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.febslet.2004.04.028","article-title":"Staphylococcus aureus peptidoglycan stimulates granulocyte macrophage colony-stimulating factor production from human epidermal keratinocytes via mitogen-activated protein kinases","volume":"566","author":"Matsubara","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1111\/bjd.15139-BIB0053|bjd15139-cit-0053","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/j.1600-0625.2011.01277.x","article-title":"Intrinsic alterations of pro-inflammatory mediators in unstimulated and TLR-2 stimulated keratinocytes from atopic dermatitis patients","volume":"20","author":"Niebuhr","year":"2011","journal-title":"Exp Dermatol"},{"key":"10.1111\/bjd.15139-BIB0054|bjd15139-cit-0054","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1111\/all.12428","article-title":"Impaired NLRP3 inflammasome expression and function in atopic dermatitis due to Th2 milieu","volume":"69","author":"Niebuhr","year":"2014","journal-title":"Allergy"},{"key":"10.1111\/bjd.15139-BIB0055|bjd15139-cit-0055","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.meegid.2013.03.020","article-title":"Staphylococcus aureus: determinants of human carriage","volume":"21","author":"Sollid","year":"2014","journal-title":"Infect Genet Evol"},{"key":"10.1111\/bjd.15139-BIB0056|bjd15139-cit-0056","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1128\/JCM.01822-07","article-title":"Genotypic characteristics of Staphylococcus aureus isolates from a multinational trial of complicated skin and skin structure infections","volume":"46","author":"Campbell","year":"2008","journal-title":"J Clin Microbiol"},{"key":"10.1111\/bjd.15139-BIB0057|bjd15139-cit-0057","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1128\/JCM.00698-07","article-title":"Epidemiological characteristics of methicillin-resistant Staphylococcus aureus isolates from children with eczematous atopic dermatitis lesions","volume":"46","author":"Chung","year":"2008","journal-title":"J Clin Microbiol"},{"key":"10.1111\/bjd.15139-BIB0058|bjd15139-cit-0058","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1365-2133.1974.tb06447.x","article-title":"Staphylococcus aureus in the lesions of atopic dermatitis","volume":"90","author":"Leyden","year":"1974","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.15139-BIB0059|bjd15139-cit-0059","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1046\/j.1365-2133.1998.02271.x","article-title":"Flucloxacillin in the treatment of atopic dermatitis","volume":"138","author":"Ewing","year":"1998","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.15139-BIB0060|bjd15139-cit-0060","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1067\/mai.2001.118598","article-title":"Effects of cefuroxime axetil on Staphylococcus aureus colonization and superantigen production in atopic dermatitis","volume":"108","author":"Boguniewicz","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/bjd.15139-BIB0061|bjd15139-cit-0061","first-page":"248","article-title":"[Topical treatment of atopic dermatitis with Hypericum cream. A randomised, placebo-controlled, double-blind half-side comparison study]","volume":"54","author":"Schempp","year":"2003","journal-title":"Hautarzt"},{"key":"10.1111\/bjd.15139-BIB0062|bjd15139-cit-0062","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1111\/j.1468-3083.2008.02716.x","article-title":"A randomized, double-blind study to assess the efficacy of addition of tetracycline to triamcinolone acetonide in the treatment of moderate to severe atopic dermatitis","volume":"22","author":"Schuttelaar","year":"2008","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1111\/bjd.15139-BIB0063|bjd15139-cit-0063","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1365-2133.2010.09743.x","article-title":"Interventions to reduce Staphylococcus aureus in the management of atopic eczema: an updated Cochrane review","volume":"163","author":"Bath-Hextall","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.15139-BIB0064|bjd15139-cit-0064","first-page":"CD003871","article-title":"Interventions to reduce Staphylococcus aureus in the management of atopic eczema","volume":"3","author":"Birnie","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1111\/bjd.15139-BIB0065|bjd15139-cit-0065","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.immuni.2015.03.014","article-title":"Dysbiosis and Staphylococcus aureus colonization drives inflammation in atopic dermatitis","volume":"42","author":"Kobayashi","year":"2015","journal-title":"Immunity"},{"key":"10.1111\/bjd.15139-BIB0066|bjd15139-cit-0066","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1111\/j.1462-5822.2008.01166.x","article-title":"The expression of alpha-haemolysin is required for Staphylococcus aureus phagosomal escape after internalization in CFT-1 cells","volume":"10","author":"Jarry","year":"2008","journal-title":"Cell Microbiol"},{"key":"10.1111\/bjd.15139-BIB0067|bjd15139-cit-0067","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1086\/320519","article-title":"Intracellular persistence of Staphylococcus aureus small-colony variants within keratinocytes: a cause for antibiotic treatment failure in a patient with Darier's disease","volume":"32","author":"Eiff","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.1111\/bjd.15139-BIB0068|bjd15139-cit-0068","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jaad.2014.03.023","article-title":"Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies","volume":"71","author":"Eichenfield","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.15139-BIB0069|bjd15139-cit-0069","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1185\/030079906X99990","article-title":"Efficacy and safety of silver textile in the treatment of atopic dermatitis (AD)","volume":"22","author":"Juenger","year":"2006","journal-title":"Curr Med Res Opin"},{"key":"10.1111\/bjd.15139-BIB0070|bjd15139-cit-0070","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1468-3083.2006.01526.x","article-title":"Efficacy and functionality of silver-coated textiles in patients with atopic eczema","volume":"20","author":"Gauger","year":"2006","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"Suppl. 2","key":"10.1111\/bjd.15139-BIB0071|bjd15139-cit-0071","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000246033","article-title":"New successful treatment with disinfectant for atopic dermatitis","volume":"195","author":"Sugimoto","year":"1997","journal-title":"Dermatology"},{"key":"10.1111\/bjd.15139-BIB0072|bjd15139-cit-0072","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.cell.2014.05.052","article-title":"Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences","volume":"158","author":"Cox","year":"2014","journal-title":"Cell"},{"key":"10.1111\/bjd.15139-BIB0073|bjd15139-cit-0073","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1038\/ncomms4114","article-title":"Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection","volume":"5","author":"Theriot","year":"2014","journal-title":"Nat Commun"},{"key":"10.1111\/bjd.15139-BIB0074|bjd15139-cit-0074","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1080\/14760584.2016.1179583","article-title":"Staphylococcus aureus: the current state of disease, pathophysiology and strategies for prevention","volume":"15","author":"Dayan","year":"2016","journal-title":"Expert Rev Vaccines"},{"key":"10.1111\/bjd.15139-BIB0075|bjd15139-cit-0075","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1093\/infdis\/jir441","article-title":"Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection","volume":"204","author":"Kobayashi","year":"2011","journal-title":"J Infect Dis"},{"key":"10.1111\/bjd.15139-BIB0076|bjd15139-cit-0076","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1093\/cid\/cit123","article-title":"A serologic correlate of protective immunity against community-onset Staphylococcus aureus infection","volume":"56","author":"Fritz","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1111\/bjd.15139-BIB0077|bjd15139-cit-0077","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1086\/656043","article-title":"Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model","volume":"202","author":"Kennedy","year":"2010","journal-title":"J Infect Dis"},{"key":"10.1111\/bjd.15139-BIB0078|bjd15139-cit-0078","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1128\/CVI.05589-11","article-title":"Identification of anti-alpha toxin monoclonal antibodies that reduce the severity of Staphylococcus aureus dermonecrosis and exhibit a correlation between affinity and potency","volume":"19","author":"Tkaczyk","year":"2012","journal-title":"Clin Vaccine Immunol"},{"key":"10.1111\/bjd.15139-BIB0079|bjd15139-cit-0079","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1128\/AAC.03918-14","article-title":"Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model","volume":"59","author":"Hilliard","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1111\/bjd.15139-BIB0080|bjd15139-cit-0080","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1128\/AAC.02190-13","article-title":"Assessment of an anti-alpha-toxin monoclonal antibody for prevention and treatment of Staphylococcus aureus-induced pneumonia","volume":"58","author":"Hua","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1111\/bjd.15139-BIB0081|bjd15139-cit-0081","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4161\/19420862.2014.985132","article-title":"Five birds, one stone: neutralization of \u03b1-hemolysin and 4 bi-component leukocidins of Staphylococcus aureus with a single human monoclonal antibody","volume":"7","author":"Rouha","year":"2015","journal-title":"MAbs"},{"key":"10.1111\/bjd.15139-BIB0082|bjd15139-cit-0082","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1128\/AAC.00973-09","article-title":"Prevention and treatment of Staphylococcus aureus pneumonia with a beta-cyclodextrin derivative","volume":"54","author":"Ragle","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1111\/bjd.15139-BIB0083|bjd15139-cit-0083","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1093\/infdis\/jiu223","article-title":"Targeting Staphylococcus aureus alpha-toxin as a novel approach to reduce severity of recurrent skin and soft-tissue infections","volume":"210","author":"Sampedro","year":"2014","journal-title":"J Infect Dis"},{"key":"10.1111\/bjd.15139-BIB0084|bjd15139-cit-0084","doi-asserted-by":"crossref","first-page":"e0116945","DOI":"10.1371\/journal.pone.0116945","article-title":"Evaluation of approaches to monitor Staphylococcus aureus virulence factor expression during human disease","volume":"10","author":"Rozemeijer","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1111\/bjd.15139-BIB0085|bjd15139-cit-0085","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1128\/IAI.00258-15","article-title":"Four-component Staphylococcus aureus vaccine 4C-staph enhances Fcgamma receptor expression in neutrophils and monocytes and mitigates S. aureus infection in neutropenic mice","volume":"83","author":"Torre","year":"2015","journal-title":"Infect Immun"},{"key":"10.1111\/bjd.15139-BIB0086|bjd15139-cit-0086","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-6968.2002.tb11448.x","article-title":"Antibacterial properties of cationic steroid antibiotics","volume":"217","author":"Savage","year":"2002","journal-title":"FEMS Microbiol Lett"},{"key":"10.1111\/bjd.15139-BIB0087|bjd15139-cit-0087","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jaci.2006.04.033","article-title":"Innate immune defects in atopic dermatitis","volume":"118","author":"McGirt","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/bjd.15139-BIB0088|bjd15139-cit-0088","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jaci.2008.08.020","article-title":"Administration of oral vitamin D induces cathelicidin production in atopic individuals","volume":"122","author":"Hata","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/bjd.15139-BIB0089|bjd15139-cit-0089","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1172\/JCI30142","article-title":"Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism","volume":"117","author":"Schauber","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1111\/bjd.15139-BIB0090|bjd15139-cit-0090","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1600-065X.2011.01027.x","article-title":"Atopic dermatitis: a disease of altered skin barrier and immune dysregulation","volume":"242","author":"Boguniewicz","year":"2011","journal-title":"Immunol Rev"},{"key":"10.1111\/bjd.15139-BIB0091|bjd15139-cit-0091","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jaci.2007.10.043","article-title":"Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis","volume":"121","author":"Lee","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/bjd.15139-BIB0092|bjd15139-cit-0092","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jaci.2009.11.027","article-title":"Recent insights into atopic dermatitis and implications for management of infectious complications","volume":"125","author":"Boguniewicz","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/bjd.15139-BIB0093|bjd15139-cit-0093","article-title":"Lysin therapy for Staphylococcus aureus and other bacterial pathogens","author":"Fischetti","year":"2016","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1111\/bjd.15139-BIB0094|bjd15139-cit-0094","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1093\/infdis\/jit637","article-title":"Combination therapy with lysin CF-301 and antibiotic is superior to antibiotic alone for treating methicillin-resistant Staphylococcus aureus-induced murine bacteremia","volume":"209","author":"Schuch","year":"2014","journal-title":"J Infect Dis"},{"key":"10.1111\/bjd.15139-BIB0095|bjd15139-cit-0095","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jaip.2014.04.007","article-title":"Recurrent MRSA skin infections in atopic dermatitis","volume":"2","author":"Ong","year":"2014","journal-title":"J Allergy Clin Immunol Pract"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.15139","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.15139","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/bjd.15139\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T14:24:13Z","timestamp":1676384653000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/177\/1\/63\/6601919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,11]]},"references-count":95,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"URL":"https:\/\/doi.org\/10.1111\/bjd.15139","archive":["Portico"],"relation":{},"ISSN":["0007-0963"],"issn-type":[{"value":"0007-0963","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6,11]]}}}