{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T03:42:21Z","timestamp":1770608541970,"version":"3.49.0"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T00:00:00Z","timestamp":1508716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T00:00:00Z","timestamp":1508716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007162","name":"Guangdong Science and Technology Department","doi-asserted-by":"publisher","award":["JZF No. (2011) 861"],"award-info":[{"award-number":["JZF No. (2011) 861"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC, 81502593"],"award-info":[{"award-number":["NSFC, 81502593"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Dermatol"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1111\/bjd.15588","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T18:32:46Z","timestamp":1492108366000},"source":"Crossref","is-referenced-by-count":5,"title":["Targeted next\u2010generation sequencing identifies nine novel filaggrin gene variants in Chinese Han patients with ichthyosis vulgaris"],"prefix":"10.1093","volume":"177","author":[{"given":"S.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology Wuhan Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Kong","sequence":"additional","affiliation":[{"name":"Prenatal Diagnosis Center The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Wei","sequence":"additional","affiliation":[{"name":"BGI\u2010Wuhan Wuhan 430075 China"},{"name":"BGI\u2010Shenzhen Shenzhen 518083 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Sun","sequence":"additional","affiliation":[{"name":"BGI\u2010Wuhan Wuhan 430075 China"},{"name":"BGI\u2010Shenzhen Shenzhen 518083 China"},{"name":"Department of Biology University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1268-5345","authenticated-orcid":false,"given":"D.","family":"Yin","sequence":"additional","affiliation":[{"name":"BGI\u2010Wuhan Wuhan 430075 China"},{"name":"BGI\u2010Shenzhen Shenzhen 518083 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Affiliated Hospital of Zhengzhou University Zhengzhou 450052 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Du","sequence":"additional","affiliation":[{"name":"BGI\u2010Wuhan Wuhan 430075 China"},{"name":"BGI\u2010Shenzhen Shenzhen 518083 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Man","sequence":"additional","affiliation":[{"name":"BGI\u2010Wuhan Wuhan 430075 China"},{"name":"BGI\u2010Shenzhen Shenzhen 518083 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Mao","sequence":"additional","affiliation":[{"name":"BGI\u2010Wuhan Wuhan 430075 China"},{"name":"BGI\u2010Shenzhen Shenzhen 518083 China"},{"name":"College of Life Sciences Hubei University Wuhan 430062 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Li","sequence":"additional","affiliation":[{"name":"Center of Prenatal Diagnosis Changsha Maternal and Child Health Hospital Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wuhan Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Yang","sequence":"additional","affiliation":[{"name":"BGI\u2010Wuhan Wuhan 430075 China"},{"name":"BGI\u2010Shenzhen Shenzhen 518083 China"},{"name":"Department of Obstetrics and Gynecology The Second Affiliated Hospital of Zhengzhou University Zhengzhou 450052 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,10,23]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12219"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12264813"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700876"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2020"},{"key":"e_1_2_3_6_1","doi-asserted-by":"crossref","first-page":"23772","DOI":"10.1016\/S0021-9258(18)35905-2","article-title":"Characterization of the human epidermal profilaggrin gene. Genomic organization and identification of an S\u2010100\u2010like calcium binding domain at the amino terminus","volume":"267","author":"Presland RB","year":"1992","journal-title":"J Biol Chem"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1743"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21953"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.15588","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjd.15588","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjd.15588","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjd.15588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T14:27:08Z","timestamp":1676384828000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/177\/5\/e202\/6749714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,23]]},"references-count":7,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,11]]},"published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/bjd.15588"],"URL":"https:\/\/doi.org\/10.1111\/bjd.15588","archive":["Portico"],"relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,23]]}}}