{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:21:51Z","timestamp":1782955311319,"version":"3.54.5"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Department of Dermatology"},{"DOI":"10.13039\/501100016380","name":"Bispebjerg Hospital","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100016380","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Copenhagen"},{"name":"Denmark and the Department of Dermatology"},{"name":"Sahlgrenska Hospital"},{"name":"Gothenburg"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Actinic keratoses (AKs) in solid organ transplant recipients (OTRs) are difficult-to-treat premalignancies and comparison of topical therapies is therefore warranted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In an intraindividual study to compare the efficacy and safety of field treatment with methyl aminolaevulinate photodynamic therapy (MAL-PDT) and imiquimod (IMIQ) for AKs in OTRs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>OTRs (n = 35) with 572 AKs (grade I\u2013III) in two similar areas on the face, scalp, dorsal hands or forearms were included. All patients received one MAL-PDT and one IMIQ session (three applications per week for 4 weeks) in each study area according to randomization. Treatments were repeated after 2 months (IMIQ) and 3 months (PDT) in skin with incomplete AK response. Outcome measures were complete lesion response (CR), skin reactions, laboratory results and treatment preference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The majority of study areas received two treatment sessions (PDT n = 25 patients; IMIQ n = 29 patients). At 3 months after two treatments, skin treated with PDT achieved a higher rate of CR (AK I\u2013III median 78%; range 50\u2013100) compared with IMIQ-treated skin areas (median 61%, range 33\u2013100; P &amp;lt; 0\u00b7001). Fewer emergent AKs were seen in PDT-treated skin vs. IMIQ-treated skin (0\u00b77 vs. 1\u00b75 AKs, P = 0\u00b704). Patients developed more intense inflammatory skin reactions following PDT, which resolved more rapidly compared with IMIQ (median 10 days vs. 18 days, P &amp;lt; 0\u00b701). Patient preference (P = 0\u00b747) and cosmesis (P &amp;gt; 0\u00b730) were similar for PDT and IMIQ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with IMIQ, PDT treatment obtained a higher rate of AK clearance at 3-month follow-up and achieved shorter-lasting, but more intense, short-term skin reactions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bjd.15884","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T20:12:33Z","timestamp":1502395953000},"page":"903-909","source":"Crossref","is-referenced-by-count":42,"title":["Photodynamic therapy is more effective than imiquimod for actinic keratosis in organ transplant recipients: a randomized intraindividual controlled trial"],"prefix":"10.1093","volume":"178","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4272-4889","authenticated-orcid":false,"given":"K.","family":"Togsverd-Bo","sequence":"first","affiliation":[{"name":"Department of Dermatology Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Halldin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sahlgrenska Hospital University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Sandberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sahlgrenska Hospital University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sahlgrenska Hospital University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Wennberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sahlgrenska Hospital University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.S.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Nephrology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.C.","family":"Wulf","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"H\u00e6dersdal","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,4,1]]},"reference":[{"key":"2023011316193137100_bjd15884-bib-0001","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1056\/NEJMra022137","article-title":"Skin cancers after organ transplantation","volume":"348","author":"Euvrard","year":"2003","journal-title":"N Engl J Med"},{"key":"2023011316193137100_bjd15884-bib-0002","doi-asserted-by":"crossref","first-page":"474","DOI":"10.2340\/00015555-0919","article-title":"Skin cancer risk among solid organ recipients: a nationwide cohort study in Denmark","volume":"90","author":"Jensen","year":"2010","journal-title":"Acta Derm Venereol"},{"key":"2023011316193137100_bjd15884-bib-0003","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.trre.2010.05.002","article-title":"Dermatopathology of skin cancer in solid organ transplant recipients","volume":"24","author":"Stoff","year":"2010","journal-title":"Transplant Rev (Orlando)"},{"key":"2023011316193137100_bjd15884-bib-0004","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1001\/archderm.141.4.447","article-title":"Cutaneous squamous cell carcinoma in organ transplant recipients: a study of the Swedish cohort with regard to tumor site","volume":"141","author":"Lindelof","year":"2005","journal-title":"Arch Dermatol"},{"key":"2023011316193137100_bjd15884-bib-0005","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jaad.2010.11.062","article-title":"Skin cancer in solid organ transplant recipients: advances in therapy and management: part I. 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