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However, the potential role of memory T cells in keloid disease (KD) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Due to their important role in regulating inflammation, we investigated the characteristics of CD45RO+ memory T cells in KD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Primary cutaneous cells were isolated from keloid scars and normal skin by enzymic digestion. Peripheral blood mononuclear cells were isolated from a related blood sample, and flow cytometry was applied to identify the phenotypic and functional abnormalities of memory T cells in KD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed that the majority of T lymphocytes in keloid scars had the memory phenotype, and a greater number of the CD8+ memory T cells in keloid scars produced lower levels of tumour necrosis factor (TNF)-\u03b1. This abnormal cytokine production was even more distinct in Forkhead box (FOX)P3\u2212 CD8\u2212 memory T cells, with lower TNF-\u03b1 production and enhanced interferon-\u03b3 production. Furthermore, FOXP3+ CD8\u2212 memory T cells in keloid scars were abnormal, including showing reduced CD25 and cytotoxic T-lymphocyte-associated antigen 4 expression and interleukin-10 production. In addition, a significant decrease in the number of CD4+ CD25high FOXP3+ regulatory T cells was identified in patients with multiple keloid scars. We also found that there was significantly increased infiltration of CD103+ CD8+ memory T cells in keloid scars.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings preliminarily elucidate the abnormalities of CD45RO+ memory T cells in keloid scars and provide early evidence that a disrupted T-cell response contributes to the progression of KD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bjd.16173","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T02:22:38Z","timestamp":1512094958000},"page":"940-950","source":"Crossref","is-referenced-by-count":49,"title":["Characterization of CD45RO+ memory T lymphocytes in keloid 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