{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:45:20Z","timestamp":1788432320569,"version":"build-2803163510"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T00:00:00Z","timestamp":1553299200000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K19709"],"award-info":[{"award-number":["16K19709"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008880","name":"Kanae Foundation for the Promotion of Medical Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008880","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Dermatol"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1111\/bjd.16237","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T02:08:36Z","timestamp":1513217316000},"page":"1373-1382","source":"Crossref","is-referenced-by-count":22,"title":["Interleukin-25 is involved in cutaneous T-cell lymphoma progression by establishing a T helper 2-dominant microenvironment"],"prefix":"10.1093","volume":"178","author":[{"given":"R.","family":"Nakajima","sequence":"first","affiliation":[{"name":"Department of Dermatology; Graduate School of Medicine; University of Tokyo; Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1879-3128","authenticated-orcid":false,"given":"T.","family":"Miyagaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology; Graduate School of Medicine; University of Tokyo; Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hirakawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology; Graduate School of Medicine; University of Tokyo; Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Dermatology; Graduate School of Medicine; University of Tokyo; Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology; Graduate School of Medicine; University of Tokyo; Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Suga","sequence":"additional","affiliation":[{"name":"Department of Dermatology; Graduate School of Medicine; University of Tokyo; Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Yoshizaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology; Graduate School of Medicine; University of Tokyo; Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Dermatology; Graduate School of Medicine; University of Tokyo; Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Dermatology; Graduate School of Medicine; University of Tokyo; Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sugaya","sequence":"additional","affiliation":[{"name":"Department of Dermatology; Graduate School of Medicine; University of Tokyo; Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Dermatology; Graduate School of Medicine; University of Tokyo; Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,3,23]]},"reference":[{"key":"10.1111\/bjd.16237-BIB0001|bjd16237-cit-0001","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0140-6736(08)60420-1","article-title":"Mycosis fungoides and S\u00e9zary syndrome","volume":"371","author":"Hwang","year":"2008","journal-title":"Lancet"},{"key":"10.1111\/bjd.16237-BIB0002|bjd16237-cit-0002","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/1523-1747.ep12398454","article-title":"Th2 cytokine mRNA expression in skin in cutaneous T-cell lymphoma","volume":"103","author":"Vowels","year":"1994","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.16237-BIB0003|bjd16237-cit-0003","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/1523-1747.ep12611877","article-title":"Aberrant cytokine production by Sezary syndrome patients: cytokine secretion pattern resembles murine Th2 cells","volume":"99","author":"Vowels","year":"1992","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.16237-BIB0004|bjd16237-cit-0004","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1182\/blood.V88.4.1383.bloodjournal8841383","article-title":"S\u00e9zary syndrome T-cell clones display T-helper 2 cytokines and express the accessory factor-1 (interferon-gamma receptor beta-chain)","volume":"88","author":"Dummer","year":"1996","journal-title":"Blood"},{"key":"10.1111\/bjd.16237-BIB0005|bjd16237-cit-0005","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/1523-1747.ep12330869","article-title":"Progression of mycosis fungoides is associated with increasing cutaneous expression of interleukin 10 mRNA","volume":"107","author":"Asadullah","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.16237-BIB0006|bjd16237-cit-0006","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/1346-8138.12341","article-title":"Phase II study of i.v. interferon-gamma in Japanese patients with mycosis fungoides","volume":"41","author":"Sugaya","year":"2014","journal-title":"J Dermatol"},{"key":"10.1111\/bjd.16237-BIB0007|bjd16237-cit-0007","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S1074-7613(01)00243-6","article-title":"IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo","volume":"15","author":"Fort","year":"2001","journal-title":"Immunity"},{"key":"10.1111\/bjd.16237-BIB0008|bjd16237-cit-0008","doi-asserted-by":"crossref","first-page":"6559","DOI":"10.4049\/jimmunol.167.11.6559","article-title":"Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice","volume":"167","author":"Pan","year":"2001","journal-title":"J Immunol"},{"key":"10.1111\/bjd.16237-BIB0009|bjd16237-cit-0009","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1182\/blood-2002-09-2817","article-title":"Mast cells produce interleukin-25 upon Fc epsilon RI-mediated activation","volume":"101","author":"Ikeda","year":"2003","journal-title":"Blood"},{"key":"10.1111\/bjd.16237-BIB0010|bjd16237-cit-0010","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1084\/jem.20061675","article-title":"Interleukin 25 promotes the initiation of proallergic type 2 responses","volume":"204","author":"Angkasekwinai","year":"2007","journal-title":"J Exp Med"},{"key":"10.1111\/bjd.16237-BIB0011|bjd16237-cit-0011","doi-asserted-by":"crossref","first-page":"31834","DOI":"10.1074\/jbc.M109.025940","article-title":"Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase Cepsilon-dependent manner","volume":"284","author":"Sonobe","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1111\/bjd.16237-BIB0012|bjd16237-cit-0012","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1074\/jbc.M008289200","article-title":"IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1","volume":"276","author":"Lee","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1111\/bjd.16237-BIB0013|bjd16237-cit-0013","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4049\/jimmunol.169.1.443","article-title":"New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25","volume":"169","author":"Hurst","year":"2002","journal-title":"J Immunol"},{"key":"10.1111\/bjd.16237-BIB0014|bjd16237-cit-0014","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.4049\/jimmunol.181.6.4299","article-title":"Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities","volume":"181","author":"Rickel","year":"2008","journal-title":"J Immunol"},{"key":"10.1111\/bjd.16237-BIB0015|bjd16237-cit-0015","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1023\/A:1027360106635","article-title":"Interleukin-17 and its receptor","volume":"17","author":"Spriggs","year":"1997","journal-title":"J Clin Immunol"},{"key":"10.1111\/bjd.16237-BIB0016|bjd16237-cit-0016","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1084\/jem.20070406","article-title":"IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells","volume":"204","author":"Wang","year":"2007","journal-title":"J Exp Med"},{"key":"10.1111\/bjd.16237-BIB0017|bjd16237-cit-0017","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/jid.2010.277","article-title":"IL-25 in atopic dermatitis: a possible link between inflammation and skin barrier dysfunction?","volume":"131","author":"Hvid","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.16237-BIB0018|bjd16237-cit-0018","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/all.12633","article-title":"Mutual upregulation of endothelin-1 and IL-25 in atopic dermatitis","volume":"70","author":"Aktar","year":"2015","journal-title":"Allergy"},{"key":"10.1111\/bjd.16237-BIB0019|bjd16237-cit-0019","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cyto.2012.10.031","article-title":"IL-4 up-regulates epidermal chemotactic, angiogenic, and pro-inflammatory genes and down-regulates antimicrobial genes in vivo and in vitro: relevant in the pathogenesis of atopic dermatitis","volume":"61","author":"Bao","year":"2013","journal-title":"Cytokine"},{"key":"10.1111\/bjd.16237-BIB0020|bjd16237-cit-0020","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/mi.2010.68","article-title":"Interleukin-25 production is differently regulated by TNF-alpha and TGF-beta 1 in the human gut","volume":"4","author":"Fina","year":"2011","journal-title":"Mucosal Immunol"},{"key":"10.1111\/bjd.16237-BIB0021|bjd16237-cit-0021","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.archoralbio.2013.10.004","article-title":"Th2 cytokines efficiently stimulate periostin production in gingival fibroblasts but periostin does not induce an inflammatory response in gingival epithelial cells","volume":"59","author":"Nakajima","year":"2014","journal-title":"Arch Oral Biol"},{"key":"10.1111\/bjd.16237-BIB0022|bjd16237-cit-0022","doi-asserted-by":"crossref","first-page":"6241","DOI":"10.1158\/0008-5472.CAN-16-0992","article-title":"Thymic stromal chemokine TSLP acts through Th2 cytokine production to induce cutaneous T-cell lymphoma","volume":"76","author":"Takahashi","year":"2016","journal-title":"Cancer Res"},{"key":"10.1111\/bjd.16237-BIB0023|bjd16237-cit-0023","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.jaci.2006.04.051","article-title":"IL-25 enhances allergic airway inflammation by amplifying a T(H)2 cell-dependent pathway in mice","volume":"118","author":"Tamachi","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/bjd.16237-BIB0024|bjd16237-cit-0024","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.jaci.2007.07.051","article-title":"Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma","volume":"120","author":"Ballantyne","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/bjd.16237-BIB0025|bjd16237-cit-0025","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1084\/jem.20051615","article-title":"Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion","volume":"203","author":"Fallon","year":"2006","journal-title":"J Exp Med"},{"key":"10.1111\/bjd.16237-BIB0026|bjd16237-cit-0026","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1084\/jem.20051496","article-title":"Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract","volume":"203","author":"Owyang","year":"2006","journal-title":"J Exp Med"},{"key":"10.1111\/bjd.16237-BIB0027|bjd16237-cit-0027","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1084\/jem.20080720","article-title":"Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine","volume":"205","author":"Zaph","year":"2008","journal-title":"J Exp Med"},{"key":"10.1111\/bjd.16237-BIB0028|bjd16237-cit-0028","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1158\/1078-0432.CCR-14-0077","article-title":"Skin barrier dysfunction and low antimicrobial peptide expression in cutaneous T-cell lymphoma","volume":"20","author":"Suga","year":"2014","journal-title":"Clin Cancer Res"},{"key":"10.1111\/bjd.16237-BIB0029|bjd16237-cit-0029","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12079-008-0023-5","article-title":"Functional role of periostin in development and wound repair: implications for connective tissue disease","volume":"2","author":"Hamilton","year":"2008","journal-title":"J Cell Commun Signal"},{"key":"10.1111\/bjd.16237-BIB0030|bjd16237-cit-0030","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2332\/allergolint.10-OA-0297","article-title":"Periostin contributes to the pathogenesis of atopic dermatitis by inducing TSLP production from keratinocytes","volume":"61","author":"Shiraishi","year":"2012","journal-title":"Allergol Int"},{"key":"10.1111\/bjd.16237-BIB0031|bjd16237-cit-0031","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1172\/JCI58978","article-title":"Periostin promotes chronic allergic inflammation in response to Th2 cytokines","volume":"122","author":"Masuoka","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1111\/bjd.16237-BIB0032|bjd16237-cit-0032","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1164\/rccm.201403-0505OC","article-title":"Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma","volume":"190","author":"Cheng","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1111\/bjd.16237-BIB0033|bjd16237-cit-0033","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1182\/blood-2010-02-267542","article-title":"Interleukin-25: a cytokine linking eosinophils and adaptive immunity in Churg-Strauss syndrome","volume":"116","author":"Terrier","year":"2010","journal-title":"Blood"},{"key":"10.1111\/bjd.16237-BIB0034|bjd16237-cit-0034","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1001\/archderm.1991.01680090075007","article-title":"Prognostic clinicopathological factors in cutaneous T-cell lymphoma","volume":"127","author":"Marti","year":"1991","journal-title":"Arch Dermatol"},{"key":"10.1111\/bjd.16237-BIB0035|bjd16237-cit-0035","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/978-3-642-59410-6_36","article-title":"Treatment of cutaneous T cell lymphoma: 2001","volume":"160","author":"Vonderheid","year":"2002","journal-title":"Recent Results Cancer Res"},{"key":"10.1111\/bjd.16237-BIB0036|bjd16237-cit-0036","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1182\/blood-2014-07-590398","article-title":"Interleukin-13 is overexpressed in cutaneous T-cell lymphoma cells and regulates their proliferation","volume":"125","author":"Geskin","year":"2015","journal-title":"Blood"},{"key":"10.1111\/bjd.16237-BIB0037|bjd16237-cit-0037","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.4049\/jimmunol.176.2.1013","article-title":"Involvement of TNF receptor-associated factor 6 in IL-25 receptor signaling","volume":"176","author":"Maezawa","year":"2006","journal-title":"J Immunol"},{"key":"10.1111\/bjd.16237-BIB0038|bjd16237-cit-0038","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.0105-2896.2004.00192.x","article-title":"Interleukin-4-and interleukin-13-mediated host protection against intestinal nematode parasites","volume":"201","author":"Finkelman","year":"2004","journal-title":"Immunol Rev"},{"key":"10.1111\/bjd.16237-BIB0039|bjd16237-cit-0039","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.cytogfr.2006.01.004","article-title":"Signaling mechanisms, interaction partners, and target genes of STAT6","volume":"17","author":"Hebenstreit","year":"2006","journal-title":"Cytokine Growth Factor Rev"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.16237","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1111%2Fbjd.16237","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/bjd.16237\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T13:38:28Z","timestamp":1676381908000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/178\/6\/1373\/6687609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,23]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"URL":"https:\/\/doi.org\/10.1111\/bjd.16237","archive":["Portico"],"relation":{},"ISSN":["0007-0963"],"issn-type":[{"value":"0007-0963","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3,23]]}}}