{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:16:58Z","timestamp":1791980218339,"version":"4.4.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:00:00Z","timestamp":1529539200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:00:00Z","timestamp":1529539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 AR066286"],"award-info":[{"award-number":["R21 AR066286"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Veterans Affairs Merit Review","award":["I01BX000706"],"award-info":[{"award-number":["I01BX000706"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Dermatol"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1111\/bjd.16498","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T13:02:40Z","timestamp":1519909360000},"page":"669-678","source":"Crossref","is-referenced-by-count":91,"title":["Itch in dermatomyositis: the role of increased skin interleukin-31"],"prefix":"10.1093","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1585-8184","authenticated-orcid":false,"given":"H.J.","family":"Kim","sequence":"first","affiliation":[{"name":"Corporal Michael J. Crescenz VA Medical Center; Philadelphia PA U.S.A"},{"name":"Department of Dermatology; Perelman School of Medicine; University of Pennsylvania; 3400 Civic Center Boulevard Philadelphia PA 19104 U.S.A"},{"name":"Department of Dermatology; Gil Medical Center; Gachon University College of Medicine; Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zeidi","sequence":"additional","affiliation":[{"name":"Corporal Michael J. Crescenz VA Medical Center; Philadelphia PA U.S.A"},{"name":"Department of Dermatology; Perelman School of Medicine; University of Pennsylvania; 3400 Civic Center Boulevard Philadelphia PA 19104 U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bonciani","sequence":"additional","affiliation":[{"name":"Corporal Michael J. Crescenz VA Medical Center; Philadelphia PA U.S.A"},{"name":"Department of Dermatology; Perelman School of Medicine; University of Pennsylvania; 3400 Civic Center Boulevard Philadelphia PA 19104 U.S.A"},{"name":"Department of Surgery and Translational Medicine; Section of Dermatology; University of Florence; Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Pena","sequence":"additional","affiliation":[{"name":"Department of Dermatology; Perelman School of Medicine; University of Pennsylvania; 3400 Civic Center Boulevard Philadelphia PA 19104 U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8793-9456","authenticated-orcid":false,"given":"J.","family":"Tiao","sequence":"additional","affiliation":[{"name":"Corporal Michael J. Crescenz VA Medical Center; Philadelphia PA U.S.A"},{"name":"Department of Dermatology; Perelman School of Medicine; University of Pennsylvania; 3400 Civic Center Boulevard Philadelphia PA 19104 U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sahu","sequence":"additional","affiliation":[{"name":"Corporal Michael J. Crescenz VA Medical Center; Philadelphia PA U.S.A"},{"name":"Department of Dermatology; Perelman School of Medicine; University of Pennsylvania; 3400 Civic Center Boulevard Philadelphia PA 19104 U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.P.","family":"Werth","sequence":"additional","affiliation":[{"name":"Corporal Michael J. Crescenz VA Medical Center; Philadelphia PA U.S.A"},{"name":"Department of Dermatology; Perelman School of Medicine; University of Pennsylvania; 3400 Civic Center Boulevard Philadelphia PA 19104 U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,6,21]]},"reference":[{"key":"10.1111\/bjd.16498-BIB0001|bjd16498-cit-0001","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.jaad.2010.10.016","article-title":"Quality of life in dermatomyositis","volume":"65","author":"Goreshi","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.16498-BIB0002|bjd16498-cit-0002","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0733-8635(02)00021-9","article-title":"Dermatomyositis: an overview of recent progress with emphasis on dermatologic aspects","volume":"20","author":"Sontheimer","year":"2002","journal-title":"Dermatol Clin"},{"key":"10.1111\/bjd.16498-BIB0003|bjd16498-cit-0003","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1067\/mjd.2001.113686","article-title":"Juvenile dermatomyositis: a retrospective review of a 30-year experience","volume":"45","author":"Peloro","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.16498-BIB0004|bjd16498-cit-0004","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2230.2004.01510.x","article-title":"Pruritus in adult dermatomyositis","volume":"29","author":"Shirani","year":"2004","journal-title":"Clin Exp Dermatol"},{"key":"10.1111\/bjd.16498-BIB0005|bjd16498-cit-0005","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jaad.2004.12.015","article-title":"Cutaneous symptoms of dermatomyositis significantly impact patients\u2019 quality of life","volume":"54","author":"Hundley","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.16498-BIB0006|bjd16498-cit-0006","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/ni1084","article-title":"Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice","volume":"5","author":"Dillon","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1111\/bjd.16498-BIB0007|bjd16498-cit-0007","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1600-0625.2012.01487.x","article-title":"Increased frequencies of IL-31-producing T cells are found in chronic atopic dermatitis skin","volume":"21","author":"Szegedi","year":"2012","journal-title":"Exp Dermatol"},{"key":"10.1111\/bjd.16498-BIB0008|bjd16498-cit-0008","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jaci.2012.11.008","article-title":"Serum IL-31 levels are increased in a subset of patients with mastocytosis and correlate with disease severity in adult patients","volume":"132","author":"Hartmann","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/bjd.16498-BIB0009|bjd16498-cit-0009","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jdermsci.2014.02.009","article-title":"Distribution of IL-31 and its receptor expressing cells in skin of atopic dermatitis","volume":"74","author":"Kato","year":"2014","journal-title":"J Dermatol Sci"},{"key":"10.1111\/bjd.16498-BIB0010|bjd16498-cit-0010","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/j.1365-2133.2011.10487.x","article-title":"Ultraviolet B radiation and reactive oxygen species modulate interleukin-31 expression in T lymphocytes, monocytes and dendritic cells","volume":"165","author":"Cornelissen","year":"2011","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.16498-BIB0011|bjd16498-cit-0011","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.jaci.2011.10.042","article-title":"IL-31 regulates differentiation and filaggrin expression in human organotypic skin models","volume":"129","author":"Cornelissen","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/bjd.16498-BIB0012|bjd16498-cit-0012","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/exd.12587","article-title":"Repeated administration of IL-31 upregulates IL-31 receptor A (IL-31RA) in dorsal root ganglia and causes severe itch-associated scratching behaviour in mice","volume":"24","author":"Arai","year":"2015","journal-title":"Exp Dermatol"},{"key":"10.1111\/bjd.16498-BIB0013|bjd16498-cit-0013","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jaci.2005.10.033","article-title":"IL-31: a new link between T cells and pruritus in atopic skin inflammation","volume":"117","author":"Sonkoly","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/bjd.16498-BIB0014|bjd16498-cit-0014","doi-asserted-by":"crossref","first-page":"894","DOI":"10.2340\/00015555-2417","article-title":"Cutaneous T-cell lymphoma and pruritus: the expression of IL-31 and its receptors in the skin","volume":"96","author":"Nattkemper","year":"2016","journal-title":"Acta Derm Venereol"},{"key":"10.1111\/bjd.16498-BIB0015|bjd16498-cit-0015","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/j.jid.2017.05.035","article-title":"Cannabinoid reduces inflammatory cytokines, tumor necrosis factor-\u03b1, and type I interferons in dermatomyositis in vitro","volume":"137","author":"Robinson","year":"2017","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.16498-BIB0016|bjd16498-cit-0016","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1365-2230.2009.03218.x","article-title":"Pruritus measurement and treatment","volume":"34","author":"Langner","year":"2009","journal-title":"Clin Exp Dermatol"},{"key":"10.1111\/bjd.16498-BIB0017|bjd16498-cit-0017","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1365-2133.2008.08711.x","article-title":"Comparison of the reliability and validity of outcome instruments for cutaneous dermatomyositis","volume":"159","author":"Klein","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.16498-BIB0018|bjd16498-cit-0018","doi-asserted-by":"crossref","first-page":"170ra16","DOI":"10.1126\/scitranslmed.3005374","article-title":"TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation","volume":"5","author":"Kim","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1111\/bjd.16498-BIB0019|bjd16498-cit-0019","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.2169\/internalmedicine.47.0967","article-title":"Flow cytometric analysis of lymphocyte subpopulations and Th1\/Th2 balance in patients with polymyositis and dermatomyositis","volume":"47","author":"Ishii","year":"2008","journal-title":"Intern Med"},{"key":"10.1111\/bjd.16498-BIB0020|bjd16498-cit-0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4137\/CMAMD.S10272","article-title":"Phenotypes of peripheral blood lymphocytes and cytokine expression in polymyositis and dermatomyositis before treatment and after clinical remission","volume":"5","author":"Shimojima","year":"2012","journal-title":"Clin Med Insights Arthritis Musculoskelet Disord"},{"key":"10.1111\/bjd.16498-BIB0021|bjd16498-cit-0021","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/j.1398-9995.2011.02545.x","article-title":"Functional effects of interleukin 31 in human primary keratinocytes","volume":"66","author":"Kasraie","year":"2011","journal-title":"Allergy"},{"key":"10.1111\/bjd.16498-BIB0022|bjd16498-cit-0022","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.cytogfr.2008.08.003","article-title":"Structures and biological functions of IL-31 and IL-31 receptors","volume":"19","author":"Zhang","year":"2008","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1111\/bjd.16498-BIB0023|bjd16498-cit-0023","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1365-3164.2012.01098.x","article-title":"Interleukin-31: its role in canine pruritus and naturally occurring canine atopic dermatitis","volume":"24","author":"Gonzales","year":"2013","journal-title":"Vet Dermatol"},{"key":"10.1111\/bjd.16498-BIB0024|bjd16498-cit-0024","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2340\/00015555-1191","article-title":"IL-31 expression by inflammatory cells is preferentially elevated in atopic dermatitis","volume":"92","author":"Nobbe","year":"2012","journal-title":"Acta Derm Venereol"},{"key":"10.1111\/bjd.16498-BIB0025|bjd16498-cit-0025","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jaci.2008.05.047","article-title":"Correlation of IL-31 serum levels with severity of atopic dermatitis","volume":"122","author":"Raap","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/bjd.16498-BIB0026|bjd16498-cit-0026","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1468-3083.2010.03794.x","article-title":"Serum measurement of interleukin-31 (IL-31) in paediatric atopic dermatitis: elevated levels correlate with severity scoring","volume":"25","author":"Ezzat","year":"2011","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1111\/bjd.16498-BIB0027|bjd16498-cit-0027","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.1600-0625.2010.01067.x","article-title":"Increased levels of serum IL-31 in chronic spontaneous urticaria","volume":"19","author":"Raap","year":"2010","journal-title":"Exp Dermatol"},{"key":"10.1111\/bjd.16498-BIB0028|bjd16498-cit-0028","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1111\/j.1468-3083.2012.04495.x","article-title":"Increased CCL18 expression in patients with cutaneous T-cell lymphoma: association with disease severity and prognosis","volume":"27","author":"Miyagaki","year":"2013","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1111\/bjd.16498-BIB0029|bjd16498-cit-0029","doi-asserted-by":"crossref","first-page":"282","DOI":"10.2340\/00015555-1345","article-title":"Serum IL-31 levels are increased in patients with cutaneous T-cell lymphoma","volume":"92","author":"Ohmatsu","year":"2012","journal-title":"Acta Derm Venereol"},{"key":"10.1111\/bjd.16498-BIB0030|bjd16498-cit-0030","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1038\/jid.2013.227","article-title":"IL-31 is produced by the malignant T-cell population in cutaneous T-cell lymphoma and correlates with CTCL pruritus","volume":"133","author":"Singer","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.16498-BIB0031|bjd16498-cit-0031","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.jaad.2014.08.004","article-title":"Interleukin-31 is associated with uremic pruritus in patients receiving hemodialysis","volume":"71","author":"Ko","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.16498-BIB0032|bjd16498-cit-0032","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1600-0625.2008.00766.x","article-title":"Anti-interleukin-31-antibodies ameliorate scratching behaviour in NC\/Nga mice: a model of atopic dermatitis","volume":"18","author":"Grimstad","year":"2009","journal-title":"Exp Dermatol"},{"key":"10.1111\/bjd.16498-BIB0033|bjd16498-cit-0033","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/bjd.14207","article-title":"The first trial of CIM331, a humanized antihuman interleukin-31 receptor A antibody, in healthy volunteers and patients with atopic dermatitis to evaluate safety, tolerability and pharmacokinetics of a single dose in a randomized, double-blind, placebo-controlled study","volume":"174","author":"Nemoto","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.16498-BIB0034|bjd16498-cit-0034","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.neuroscience.2006.07.009","article-title":"Complete overlap of interleukin-31 receptor A and oncostatin M receptor \u03b2 in the adult dorsal root ganglia with distinct developmental expression patterns","volume":"142","author":"Bando","year":"2006","journal-title":"Neuroscience"},{"key":"10.1111\/bjd.16498-BIB0035|bjd16498-cit-0035","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jaci.2005.10.046","article-title":"IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis","volume":"117","author":"Bilsborough","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/bjd.16498-BIB0036|bjd16498-cit-0036","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/all.12316","article-title":"Interleukin-31 does not induce immediate itch in atopic dermatitis patients and healthy controls after skin challenge","volume":"69","author":"Hawro","year":"2014","journal-title":"Allergy"},{"key":"10.1111\/bjd.16498-BIB0037|bjd16498-cit-0037","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.jaci.2013.03.050","article-title":"Human IL-31 is induced by IL-4 and promotes TH2-driven inflammation","volume":"132","author":"Stott","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/bjd.16498-BIB0038|bjd16498-cit-0038","doi-asserted-by":"crossref","first-page":"854","DOI":"10.4049\/jimmunol.145.3.854","article-title":"Induction and regulation of IL-4 receptor expression on murine macrophage cell lines and bone marrow-derived macrophages by IFN-\u03b3","volume":"145","author":"Feldman","year":"1990","journal-title":"J Immunol"},{"key":"10.1111\/bjd.16498-BIB0039|bjd16498-cit-0039","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"10.1111\/bjd.16498-BIB0040|bjd16498-cit-0040","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1128\/CVI.00649-14","article-title":"The transforming growth factor \u03b21\/interleukin-31 pathway is upregulated in patients with hepatitis B virus-related acute-on-chronic liver failure and is associated with disease severity and survival","volume":"22","author":"Yu","year":"2015","journal-title":"Clin Vaccine Immunol"},{"key":"10.1111\/bjd.16498-BIB0041|bjd16498-cit-0041","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1089\/vim.2014.0142","article-title":"Elevated TGF-\u03b21\/IL-31 pathway is associated with the disease severity of hepatitis B virus-related liver cirrhosis","volume":"28","author":"Ming","year":"2015","journal-title":"Viral Immunol"},{"key":"10.1111\/bjd.16498-BIB0042|bjd16498-cit-0042","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/00005072-199705000-00003","article-title":"Transforming growth factor-\u03b21 in polymyositis and dermatomyositis correlates with fibrosis but not with mononuclear cell infiltrate","volume":"56","author":"Confalonieri","year":"1997","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1111\/bjd.16498-BIB0043|bjd16498-cit-0043","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12931-016-0373-0","article-title":"Ajulemic acid exerts potent anti-fibrotic effect during the fibrogenic phase of bleomycin lung","volume":"17","author":"Lucattelli","year":"2016","journal-title":"Respir Res"},{"key":"10.1111\/bjd.16498-BIB0044|bjd16498-cit-0044","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1136\/annrheumdis-2011-200314","article-title":"Synthetic cannabinoid ajulemic acid exerts potent antifibrotic effects in experimental models of systemic sclerosis","volume":"71","author":"Gonzalez","year":"2012","journal-title":"Ann Rheum Dis"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.16498","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/bjd.16498\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T07:03:02Z","timestamp":1693551782000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/179\/3\/669\/6732446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,21]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,9]]}},"URL":"https:\/\/doi.org\/10.1111\/bjd.16498","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732783436.793549356","asserted-by":"object"}]},"ISSN":["0007-0963"],"issn-type":[{"value":"0007-0963","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6,21]]}}}