{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:34:32Z","timestamp":1789893272140,"version":"4.0.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRU 303"],"award-info":[{"award-number":["CRU 303"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Dermatol"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1111\/bjd.16553","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T01:44:48Z","timestamp":1522633488000},"page":"918-924","source":"Crossref","is-referenced-by-count":38,"title":["Prospective study in bullous pemphigoid: association of high serum anti-BP180 IgG levels with increased mortality and reduced Karnofsky score"],"prefix":"10.1093","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5318-5796","authenticated-orcid":false,"given":"M.M.","family":"Holtsche","sequence":"first","affiliation":[{"name":"Department of Dermatology; University of L\u00fcbeck; L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Goletz","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology (LIED); University of L\u00fcbeck; L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"van Beek","sequence":"additional","affiliation":[{"name":"Department of Dermatology; University of L\u00fcbeck; L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Zillikens","sequence":"additional","affiliation":[{"name":"Department of Dermatology; University of L\u00fcbeck; L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Benoit","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology; University Hospital W\u00fcrzburg; W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Harman","sequence":"additional","affiliation":[{"name":"Department of Dermatology; University Hospitals Leicester; Leicester Royal Infirmary; Leicester U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Walton","sequence":"additional","affiliation":[{"name":"Castle Hill Hospital; Cottingham U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"English","sequence":"additional","affiliation":[{"name":"Queen's Medical Centre; University Hospital; Nottingham U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9396-3938","authenticated-orcid":false,"given":"M.","family":"Sticherling","sequence":"additional","affiliation":[{"name":"Department of Dermatology; University of Erlangen; Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital, Greenwich; London U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.J.","family":"Levell","sequence":"additional","affiliation":[{"name":"Norfolk and Norwich University Hospital; Norwich U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Groves","sequence":"additional","affiliation":[{"name":"Department of Immunodermatology; St John's Institute of Dermatology; St Thomas\u2019 Hospital; London U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.C.","family":"Williams","sequence":"additional","affiliation":[{"name":"Centre of Evidence Based Dermatology; University of Nottingham; Nottingham U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.R.","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry and Statistics; University of L\u00fcbeck; L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1206-8913","authenticated-orcid":false,"given":"E.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Dermatology; University of L\u00fcbeck; L\u00fcbeck Germany"},{"name":"L\u00fcbeck Institute of Experimental Dermatology (LIED); University of L\u00fcbeck; L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"members of the BLISTER Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,7,5]]},"reference":[{"key":"10.1111\/bjd.16553-BIB0001|bjd16553-cit-0001","first-page":"434","article-title":"Prospective analysis of the incidence of autoimmune bullous disorders in Lower Franconia, Germany","volume":"7","author":"Bertram","year":"2009","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1111\/bjd.16553-BIB0002|bjd16553-cit-0002","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1038\/jid.2012.35","article-title":"Incidence and mortality of bullous pemphigoid in France","volume":"132","author":"Joly","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.16553-BIB0003|bjd16553-cit-0003","doi-asserted-by":"crossref","first-page":"a180","DOI":"10.1136\/bmj.a180","article-title":"Bullous pemphigoid and pemphigus vulgaris - incidence and mortality in the UK: population based cohort study","volume":"337","author":"Langan","year":"2008","journal-title":"BMJ"},{"key":"10.1111\/bjd.16553-BIB0004|bjd16553-cit-0004","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1016\/j.jid.2016.07.013","article-title":"Prevalence and age distribution of pemphigus and pemphigoid diseases in Germany","volume":"136","author":"H\u00fcbner","year":"2016","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.16553-BIB0005|bjd16553-cit-0005","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0140-6736(12)61140-4","article-title":"Pemphigoid diseases","volume":"381","author":"Schmidt","year":"2013","journal-title":"Lancet"},{"key":"10.1111\/bjd.16553-BIB0006|bjd16553-cit-0006","first-page":"1","volume-title":"Rook's Textbook of Dermatology","author":"Schmidt","year":"2016","edition":"9"},{"key":"10.1111\/bjd.16553-BIB0007|bjd16553-cit-0007","first-page":"713","article-title":"S2K guideline for the diagnosis of pemphigus vulgaris\/foliaceus and bullous pemphigoid","volume":"13","author":"Schmidt","year":"2015","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1111\/bjd.16553-BIB0008|bjd16553-cit-0008","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1001\/archderm.136.2.174","article-title":"Serum levels of autoantibodies to BP180 correlate with disease activity in patients with bullous pemphigoid","volume":"136","author":"Schmidt","year":"2000","journal-title":"Arch Dermatol"},{"key":"10.1111\/bjd.16553-BIB0009|bjd16553-cit-0009","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0923-1811(02)00109-3","article-title":"BP180 ELISA using bacterial recombinant NC16a protein as a diagnostic and monitoring tool for bullous pemphigoid","volume":"30","author":"Kobayashi","year":"2002","journal-title":"J Dermatol Sci"},{"key":"10.1111\/bjd.16553-BIB0010|bjd16553-cit-0010","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1586\/1744666X.2016.1123092","article-title":"IgE-mediated mechanisms in bullous pemphigoid and other autoimmune bullous diseases","volume":"12","author":"Beek","year":"2016","journal-title":"Exp Rev Clin Immunol"},{"key":"10.1111\/bjd.16553-BIB0011|bjd16553-cit-0011","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1046\/j.1365-2133.2000.03661.x","article-title":"IgG, IgA and IgE autoantibodies against the ectodomain of BP180 in patients with bullous and cicatricial pemphigoid and linear IgA bullous dermatosis","volume":"143","author":"Christophoridis","year":"2000","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.16553-BIB0012|bjd16553-cit-0012","first-page":"577","article-title":"IgG4 and IgE are the major immunoglobulins targeting the NC16A domain of BP180 in bullous pemphigoid: serum levels of these immunoglobulins reflect disease activity","volume":"42","author":"Dopp","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.16553-BIB0013|bjd16553-cit-0013","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1001\/archdermatol.2007.9","article-title":"Correlation of IgE autoantibody to BP180 with a severe form of bullous pemphigoid","volume":"144","author":"Iwata","year":"2008","journal-title":"Arch Dermatol"},{"key":"10.1111\/bjd.16553-BIB0014|bjd16553-cit-0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta21100","article-title":"A randomised controlled trial to compare the safety, effectiveness and cost-effectiveness of doxycycline (200 mg\/day) with that of oral prednisolone (0.5 mg\/kg\/day) for initial treatment of bullous pemphigoid: the Bullous Pemphigoid Steroids and Tetracyclines (BLISTER) trial","volume":"21","author":"Chalmers","year":"2017","journal-title":"Health Technol Assess"},{"key":"10.1111\/bjd.16553-BIB0015|bjd16553-cit-0015","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/S0140-6736(17)30560-3","article-title":"Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic, non-inferiority, randomised controlled trial","volume":"389","author":"Williams","year":"2017","journal-title":"Lancet"},{"key":"10.1111\/bjd.16553-BIB0016|bjd16553-cit-0016","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1001\/jamadermatol.2016.3357","article-title":"Correlation of serum levels of IgE autoantibodies against BP180 with bullous pemphigoid disease activity","volume":"153","author":"Beek","year":"2017","journal-title":"JAMA Dermatol"},{"key":"10.1111\/bjd.16553-BIB0017|bjd16553-cit-0017","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1046\/j.1365-2133.2001.04471.x","article-title":"Cicatricial pemphigoid: IgA and IgG autoantibodies target epitopes on both intra- and extracellular domains of bullous pemphigoid antigen 180","volume":"145","author":"Schmidt","year":"2001","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.16553-BIB0018|bjd16553-cit-0018","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/bjd.12739","article-title":"Serum autoantibodies against the dermal-epidermal junction in patients with chronic pruritic disorders, elderly individuals and blood donors prospectively recruited","volume":"170","author":"Beek","year":"2014","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.16553-BIB0019|bjd16553-cit-0019","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1046\/j.1523-1747.1999.00808.x","article-title":"Autoantibodies in a subgroup of patients with linear IgA disease react with the NC16A domain of BP1801","volume":"113","author":"Zillikens","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1111\/bjd.16553-BIB0020|bjd16553-cit-0020","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.jaad.2004.06.004","article-title":"Comparative analysis of methods for detection of anti-laminin 5 autoantibodies in patients with anti-epiligrin cicatricial pemphigoid","volume":"51","author":"Lazarova","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.16553-BIB0021|bjd16553-cit-0021","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1365-2133.2010.10056.x","article-title":"Development of a simple enzyme-linked immunosorbent assay for the detection of autoantibodies in anti-p200 pemphigoid","volume":"164","author":"Groth","year":"2011","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.16553-BIB0022|bjd16553-cit-0022","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/S0140-6736(17)30549-4","article-title":"Doxycycline: a first-line treatment for bullous pemphigoid?","volume":"389","author":"Grantham","year":"2017","journal-title":"Lancet"},{"key":"10.1111\/bjd.16553-BIB0023|bjd16553-cit-0023","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1016\/j.jaad.2004.07.036","article-title":"Subepidermal blistering disease with autoantibodies to both the p200 autoantigen and the alpha3 chain of laminin 5","volume":"52","author":"Shimanovich","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.16553-BIB0024|bjd16553-cit-0024","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.jaad.2013.07.009","article-title":"Comparative study of direct and indirect immunofluorescence and of bullous pemphigoid 180 and 230 enzyme-linked immunosorbent assays for diagnosis of bullous pemphigoid","volume":"69","author":"S\u00e1rdy","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.16553-BIB0025|bjd16553-cit-0025","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1001\/archderm.1997.03890450048006","article-title":"Diagnostic value of indirect immunofluorescence on sodium chloride-split skin in differential diagnosis of subepidermal autoimmune bullous dermatoses","volume":"133","author":"Ghohestani","year":"1997","journal-title":"Arch Dermatol"},{"key":"10.1111\/bjd.16553-BIB0026|bjd16553-cit-0026","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1365-2133.1992.tb00651.x","article-title":"Serological diagnosis of bullous pemphigoid (BP): comparison of the sensitivity of indirect immunofluorescence on salt-split skin to immunoblotting","volume":"126","author":"Machado","year":"1992","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.16553-BIB0027|bjd16553-cit-0027","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/j.1365-2133.2012.10820.x","article-title":"Epitope mapping of BP230 leading to a novel enzyme-linked immunosorbent assay for autoantibodies in bullous pemphigoid","volume":"166","author":"Blocker","year":"2012","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.16553-BIB0028|bjd16553-cit-0028","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1600-0625.2007.00592.x","article-title":"Enzyme-linked immunosorbent assay using multimers of the 16th non-collagenous domain of the BP180 antigen for sensitive and specific detection of pemphigoid autoantibodies","volume":"16","author":"Sitaru","year":"2007","journal-title":"Exp Dermatol"},{"key":"10.1111\/bjd.16553-BIB0029|bjd16553-cit-0029","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.autrev.2012.07.006","article-title":"Diagnostic accuracy of enzyme-linked immunosorbent assays (ELISA) to detect anti-skin autoantibodies in autoimmune blistering skin diseases: a systematic review and meta-analysis","volume":"12","author":"Tampoia","year":"2012","journal-title":"Autoimmun Rev"},{"key":"10.1111\/bjd.16553-BIB0030|bjd16553-cit-0030","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/bjd.15114","article-title":"Detection of IgE autoantibodies to BP180 and BP230 and their relationship to clinical features in bullous pemphigoid","volume":"177","author":"Hashimoto","year":"2017","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.16553-BIB0031|bjd16553-cit-0031","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jdermsci.2004.10.007","article-title":"Correlation of clinical severity and ELISA indices for the NC16A domain of BP180 measured using BP180 ELISA kit in bullous pemphigoid","volume":"37","author":"Tsuji-Abe","year":"2005","journal-title":"J Dermatol Sci"},{"key":"10.1111\/bjd.16553-BIB0032|bjd16553-cit-0032","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s00403-015-1598-3","article-title":"Levels of anti-BP180 NC16A IgE do not correlate with severity of disease in the early stages of bullous pemphigoid","volume":"307","author":"Bing","year":"2015","journal-title":"Arch Dermatol Res"},{"key":"10.1111\/bjd.16553-BIB0033|bjd16553-cit-0033","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2340\/00015555-2101","article-title":"Enzyme-linked immunoassay index for anti-NC16a IgG and IgE auto-antibodies correlates with severity and activity of bullous pemphigoid","volume":"96","author":"Kalowska","year":"2016","journal-title":"Acta Derm Venereol"},{"key":"10.1111\/bjd.16553-BIB0034|bjd16553-cit-0034","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jaad.2011.06.032","article-title":"Definitions and outcome measures for bullous pemphigoid: recommendations by an international panel of experts","volume":"66","author":"Murrell","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.16553-BIB0035|bjd16553-cit-0035","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000106574","article-title":"Neurological disorders in patients with bullous pemphigoid","volume":"215","author":"Cordel","year":"2007","journal-title":"Dermatology"},{"key":"10.1111\/bjd.16553-BIB0036|bjd16553-cit-0036","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.annder.2015.12.016","article-title":"[Impact of neurological diseases on the prognosis of bullous pemphigoid: a retrospective study of 178 patients]","volume":"143","author":"Chevalier","year":"2016","journal-title":"Ann Dermatol Venereol"},{"key":"10.1111\/bjd.16553-BIB0037|bjd16553-cit-0037","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.jaad.2015.01.029","article-title":"Infectious complications in bullous pemphigoid: an analysis of risk factors","volume":"72","author":"Phoon","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/bjd.16553-BIB0038|bjd16553-cit-0038","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1001\/archderm.141.6.691","article-title":"Prediction of survival for patients with bullous pemphigoid: a prospective study","volume":"141","author":"Joly","year":"2005","journal-title":"Arch Dermatol"},{"key":"10.1111\/bjd.16553-BIB0039|bjd16553-cit-0039","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/978-3-662-45698-9_21","volume-title":"Blistering Diseases","author":"Schmidt","year":"2015","edition":"1"},{"key":"10.1111\/bjd.16553-BIB0040|bjd16553-cit-0040","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/j.1365-2133.1997.tb03654.x","article-title":"Anti-BP180 autoantibodies as a marker of poor prognosis in bullous pemphigoid: a cohort analysis of 94 elderly patients","volume":"136","author":"Bernard","year":"1997","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.16553-BIB0041|bjd16553-cit-0041","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/bjd.15649","article-title":"An open, multicentre, randomized clinical study in patients with bullous pemphigoid comparing methylprednisolone and azathioprine with methylprednisolone and dapsone","volume":"177","author":"Sticherling","year":"2017","journal-title":"Br J Dermatol"},{"key":"10.1111\/bjd.16553-BIB0042|bjd16553-cit-0042","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00403-017-1736-1","article-title":"Prognostic factors for mortality in patients with bullous pemphigoid: a meta-analysis","volume":"309","author":"Liu","year":"2017","journal-title":"Arch Dermatol Res"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.16553","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/bjd.16553\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T08:40:30Z","timestamp":1676364030000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/179\/4\/918\/6753774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,5]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"URL":"https:\/\/doi.org\/10.1111\/bjd.16553","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732961709.793554649","asserted-by":"object"}]},"ISSN":["0007-0963"],"issn-type":[{"value":"0007-0963","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7,5]]}}}