{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:31:36Z","timestamp":1780104696062,"version":"3.54.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Dermatol"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1111\/bjd.18165","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T13:08:48Z","timestamp":1559135328000},"page":"698-707","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Electron microscopy in the diagnosis of Ehlers\u2013Danlos syndromes: correlation with clinical and genetic investigations"],"prefix":"10.1093","volume":"182","author":[{"given":"C.","family":"Angwin","sequence":"first","affiliation":[{"name":"Complex Ehlers\u2013Danlos Syndromes National Service London North West University Healthcare NHS Trust Harrow Middlesex U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ghali","sequence":"additional","affiliation":[{"name":"Complex Ehlers\u2013Danlos Syndromes National Service London North West University Healthcare NHS Trust Harrow Middlesex U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Baker","sequence":"additional","affiliation":[{"name":"Sheffield Diagnostic Genetics Service Sheffield Children's NHS Foundation Trust Sheffield U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.F.","family":"Brady","sequence":"additional","affiliation":[{"name":"Complex Ehlers\u2013Danlos Syndromes National Service London North West University Healthcare NHS Trust Harrow Middlesex U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.M.","family":"Pope","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chelsea and Westminster Hospital NHS Foundation Trust London U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Vandersteen","sequence":"additional","affiliation":[{"name":"Maritime Medical Genetics Service IWK Health Centre Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Connective Tissue Disorders Service Sheffield Diagnostic Genetics Service Sheffield U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.J.P.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Laboratory Sciences University of Oxford John Radcliffe Hospital Oxford U.K."},{"name":"Department of Biological &amp; Medical Sciences Oxford Brookes University Oxford U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6341-169X","authenticated-orcid":false,"given":"F.S","family":"Dijk","sequence":"additional","affiliation":[{"name":"Complex Ehlers\u2013Danlos Syndromes National Service London North West University Healthcare NHS Trust Harrow Middlesex U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,8,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31552"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2018.04.013"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.06994.x"},{"key":"e_1_2_6_6_1","unstructured":"Chepa\u2010LotreaX FrancomanoC;National Organisation for Rare Disorders.Ehlers Danlos syndromes. Available at:https:\/\/rarediseases.org\/rare-diseases\/ehlers-danlos-syndrome\/(last accessed 7 July 2019)."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2016.06.120"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31550"},{"key":"e_1_2_6_9_1","unstructured":"MalfaitF WenstrupR De PaepeA.Classic Ehlers\u2010Danlos syndrome. Available at:https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1244\/(last accessed 7 July 2019)."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31539"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30070"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.02.018"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20151169"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304822"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31548"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00201664"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-012-1233-z"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35802"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2006.05958.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.1016\/S0021-9258(18)68776-9","article-title":"Ehlers\u2010Danlos syndrome type IV: a multi\u2010exon deletion in one of the two COL3A1 alleles affecting structure, stability, and processing of type III procollagen","volume":"263","author":"Superti\u2010Furga A","year":"1988","journal-title":"J Biol Chem"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"8561","DOI":"10.1016\/S0021-9258(18)68340-1","article-title":"Identification of a mutation that causes exon skipping during collagen pre\u2010mRNA splicing in an Ehlers\u2010Danlos syndrome variant","volume":"263","author":"Weil D","year":"1988","journal-title":"J Biol Chem"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.08.019"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa002939"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2017.02.013"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/17437199.2013.840954"},{"key":"e_1_2_6_27_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1242\/jcs.95.4.649","article-title":"Collagen fibrillogenesis in\u00a0vitro: interaction of types I and V collagen regulates fibril diameter","volume":"95","author":"Birk DE","year":"1990","journal-title":"J Cell Sci"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-46"},{"key":"e_1_2_6_29_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5070\/D30997G30Q","article-title":"Vascular Ehlers\u2010Danlos syndrome: a case with fatal outcome","volume":"17","author":"Morais P","year":"2011","journal-title":"Dermatol Online J"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008209109029157"},{"key":"e_1_2_6_31_1","first-page":"201","article-title":"Abnormal collagen fibrilstructure in the gravis form (type I) of Ehlers\u2010Danlos syndrome","volume":"40","author":"Vogel A","year":"1979","journal-title":"Lab Invest"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962011000700043"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.33.11.940"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1982.3"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3182713293"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCD.0000000000000066"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/01913120050132859"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/878107"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.4103\/neuroindia.NI_537_15"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30299"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.188"},{"key":"e_1_2_6_42_1","first-page":"695","article-title":"Ultrastructural study of the dermis in a case of type IV Ehlers\u2010Danlos syndrome","volume":"17","author":"Vitellaro\u2010Zuccarello L","year":"1985","journal-title":"J Submicrosc Cytol"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjd.18165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjd.18165","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjd.18165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T13:50:19Z","timestamp":1676382619000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/182\/3\/698\/6731434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,21]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/bjd.18165"],"URL":"https:\/\/doi.org\/10.1111\/bjd.18165","archive":["Portico"],"relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,21]]},"assertion":[{"value":"2019-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}