{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:45:13Z","timestamp":1747183513478,"version":"3.40.5"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Dermatol"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1111\/bjd.19330","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T03:24:26Z","timestamp":1593055466000},"page":"792-792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Suspension of marketing authorization for ingenol mebutate"],"prefix":"10.1093","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4070-0696","authenticated-orcid":false,"given":"M.F.","family":"Mohd Mustapa","sequence":"first","affiliation":[{"name":"British Association of Dermatologists Clinical Standards Unit London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Berker","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bristol Royal Infirmary Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"McGregor","sequence":"additional","affiliation":[{"name":"Department of Dermatology Barts Health NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.S.","family":"Exton","sequence":"additional","affiliation":[{"name":"British Association of Dermatologists Clinical Standards Unit London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.R.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Portsmouth Dermatology Centre Portsmouth Hospitals NHS Trust Portsmouth UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3393-8305","authenticated-orcid":false,"given":"N.J.","family":"Levell","sequence":"additional","affiliation":[{"name":"Norfolk and Norwich University Hospital Norwich UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,7,27]]},"reference":[{"key":"e_1_2_1_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15107"},{"key":"e_1_2_1_3_3_1","unstructured":"Medicines and Healthcare products Regulatory Agency.Class 2 medicines recall: LEO Laboratories Ltd Picato 150 mcg\/g gel EU\/1\/12\/796\/001 Picato 500 mcg\/g gel EU\/1\/12\/796\/002 (EL (20)A\/02). Available at:https:\/\/www.gov.uk\/drug-device-alerts\/class-2-medicines-recall-leo-laboratories-ltd-picato-150-mcg-g-gel-eu-1-12-796-001-picato-500-mcg-g-gel-eu-1-12-796-002-el-20-a-02(last accessed 1 July 2020)."},{"key":"e_1_2_1_3_4_1","unstructured":"US National Library of Medicine.Risk of squamous cell carcinoma on skin areas treated with ingenol mebutate gel 0.015% and imiquimod cream 5%. Available at:https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01926496(last accessed 1 July 2020)."},{"key":"e_1_2_1_3_5_1","unstructured":"US National Library of Medicine.Efficacy and safety of ingenol mebutate gel 0.06% when applied once daily for 2 3 or 4 consecutive days to a treatment area of approximately 250 cm2on trunk and extremities in subjects with actinic keratosis. Available at:https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01998984(last accessed 1 July 2020)."},{"key":"e_1_2_1_3_6_1","unstructured":"LEO Pharma.LEO Pharma initiates voluntary withdrawal of marketing authorization and possible voluntary withdrawal of Picato\u00ae in the EU and EEA. Marketing of Picato\u00ae continues in US and elsewhere. Available at:https:\/\/leo-pharma.com\/media-center\/news\/leo-pharma-initiates-voluntary-withdrawal--of-marketing-authorization(last accessed 1 July 2020)."},{"key":"e_1_2_1_3_7_1","unstructured":"Medicines and Healthcare products Regulatory Agency.Picato. Available at:https:\/\/www.gov.uk\/search\/all?keywords=picato&order=relevance(last accessed 1 July 2020)."}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjd.19330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjd.19330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjd.19330","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjd.19330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T13:57:19Z","timestamp":1676383039000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/183\/4\/792\/6761589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,27]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/bjd.19330"],"URL":"https:\/\/doi.org\/10.1111\/bjd.19330","archive":["Portico"],"relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"type":"print","value":"0007-0963"},{"type":"electronic","value":"1365-2133"}],"subject":[],"published":{"date-parts":[[2020,7,27]]},"assertion":[{"value":"2020-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}