{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:25Z","timestamp":1787013925188,"version":"build-2736575974"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"NIHR Newcastle BRC"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Background<\/jats:p>\n                  <jats:p>Skin adnexal tumours (SATs) comprise a diverse range of neoplasms, which are difficult to diagnose clinically. They present in paediatric and adult populations, and may be indicative of an underlying genetic syndrome. There is a lack of recent data on the presentation of these tumours in clinical practice in European populations.<\/jats:p>\n                  <jats:p>Objectives<\/jats:p>\n                  <jats:p>To characterize the clinical and pathological features of SATs received at a single tertiary centre over a 5-year period.<\/jats:p>\n                  <jats:p>Methods<\/jats:p>\n                  <jats:p>A retrospective health record audit of SATs received at the Department of Cellular Pathology, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, during the period November 2012 to October 2017 was performed.<\/jats:p>\n                  <jats:p>Results<\/jats:p>\n                  <jats:p>In total, 107 144 skin cases were received during the audit period. A total of 1615 cases of SATs from 1359 patients were included; 1570 (97\u00b72%) were benign and 45 (2\u00b78%) were malignant. Overall, the average age at presentation was 55 years (range 11 months to 97 years) and the male to female ratio was 0\u00b777 : 1. Sweat gland and hair follicle SATs were most frequently excised; in adults, the most frequent tumour was hidrocystoma, and in children, pilomatrixoma occurred most often. Prebiopsy diagnosis was correct in 28% of cases. Benign SATs are often markers of an associated genetic condition, which warrants improved discrimination of sporadic from genetically related SATs.<\/jats:p>\n                  <jats:p>Conclusions<\/jats:p>\n                  <jats:p>SATs are difficult to diagnose clinically, and clinicopathological correlation may help enhance discrimination of genetically related SATs from sporadic cases. These data have implications for clinical and dermatopathological training provision, the development of reporting standards, and genetic assessment of selected patients.<\/jats:p>","DOI":"10.1111\/bjd.20701","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T12:54:03Z","timestamp":1628859243000},"page":"167-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A 5-year retrospective review of skin adnexal tumours received at a tertiary dermatopathology service: implications for linked genetic diagnoses"],"prefix":"10.1093","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4389-2582","authenticated-orcid":false,"given":"S.","family":"Cook","sequence":"first","affiliation":[{"name":"Department of Pathology Royal Victoria Infirmary Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0965-7012","authenticated-orcid":false,"given":"D.","family":"Bajwa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Royal Victoria Infirmary Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8922-6791","authenticated-orcid":false,"given":"L.","family":"Hollestein","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus MC Cancer Institute Rotterdam the Netherlands"},{"name":"Department of Research Netherlands Comprehensive Cancer Organisation (IKNL) Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8563-3859","authenticated-orcid":false,"given":"A.","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Pathology Royal Victoria Infirmary Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5850-5680","authenticated-orcid":false,"given":"N.","family":"Rajan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Royal Victoria Infirmary Newcastle upon Tyne UK"},{"name":"Translational and Clinical Research\u202fInstitute Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,1]]},"reference":[{"key":"2023010800163493500_bjd20701-bib-0001","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1136\/jcp.2006.040337","article-title":"Skin adnexal neoplasms\u2013part 1: an approach to tumours of the pilosebaceous unit","volume":"60","author":"Alsaad","year":"2007","journal-title":"J Clin Pathol"},{"key":"2023010800163493500_bjd20701-bib-0002","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1136\/jcp.2006.041608","article-title":"Skin adnexal neoplasms\u2013part 2: an approach to tumours of cutaneous sweat glands","volume":"60","author":"Obaidat","year":"2007","journal-title":"J Clin Pathol"},{"key":"2023010800163493500_bjd20701-bib-0003","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3906\/sag-2002-126","article-title":"Are clinicians successful in diagnosing cutaneous adnexal tumors? 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