{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T14:29:51Z","timestamp":1782570591747,"version":"3.54.5"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:sec>\n                  <jats:title\/>\n                  <jats:p>Chronic prurigo is a distinct disease defined by the presence of chronic pruritus for at least 6 weeks, a history and\/or signs of repeated scratching, and multiple localized or generalized pruritic skin lesions (whitish or pinkish papules, nodules and\/or plaques). Although chronic prurigo is frequently named prurigo nodularis, the nodular type of chronic prurigo is only the main clinical aspect of chronic prurigo. Chronic prurigo occurs due to neural sensitization to pruritus and the development of a vicious pruritus\u2013scratching cycle. Chronic prurigo can be of allergological, dermatological, systemic, neurological, psychiatric\/psychosomatic, mixed or undetermined origin. The prevalence is still debated. The burden is high. Current treatments often remained disappointing. Fortunately, recent research results on the pathophysiology of pruritus evidenced neuroimmune interactions and allow new therapeutic perspectives. Among them, antagonists of T-helper 2 cytokines, \u03ba-opioids and Janus kinase inhibitors may be promising.<\/jats:p>\n                  <jats:p>What is already known about this topic? \u00a0Chronic prurigo or prurigo nodularis is poorly known by dermatologists and the definition was rather vague until recently.<\/jats:p>\n                  <jats:p>What does this study add? \u00a0This review provides a summary of the recent developments of nosology and research (from basic research to epidemiology and clinical research), and current and near-future management are then discussed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/bjd.21698","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T08:31:00Z","timestamp":1654245060000},"page":"464-471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Chronic prurigo"],"prefix":"10.1093","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8088-7059","authenticated-orcid":false,"given":"Laurent","family":"Misery","sequence":"first","affiliation":[{"name":"Univ Brest, LIEN Brest France"},{"name":"Department of Dermatology, Venereology and Allergology and French Expert Centre on Pruritus University Hospital of Brest Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,1]]},"reference":[{"key":"2023010808114801800_bjd21698-bib-0001","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/S0140-6736(03)12570-6","volume":"361","author":"Yosipovitch","year":"2003","journal-title":"Itch. Lancet"},{"key":"2023010808114801800_bjd21698-bib-0002","volume-title":"Pruritus","author":"Misery","year":"2017"},{"key":"2023010808114801800_bjd21698-bib-0003","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/nrneurol.2014.99","article-title":"Neuropathic pruritus","volume":"10","author":"Misery","year":"2014","journal-title":"Nat Rev Neurol"},{"key":"2023010808114801800_bjd21698-bib-0004","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2340\/00015555-3164","article-title":"European S2k Guideline on Chronic Pruritus","volume":"99","author":"Weisshaar","year":"2019","journal-title":"Acta Derm Venereol"},{"key":"2023010808114801800_bjd21698-bib-0005","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2340\/00015555-0305","article-title":"Clinical classification of itch: a position paper of the International Forum for the Study of Itch","volume":"87","author":"St\u00e4nder","year":"2007","journal-title":"Acta Derm Venereol"},{"key":"2023010808114801800_bjd21698-bib-0006","first-page":"52","article-title":"Psychogenic itch. Transl","volume":"8","author":"Misery","year":"2018","journal-title":"Psychiatry"},{"key":"2023010808114801800_bjd21698-bib-0007","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1111\/bph.15672","article-title":"Chronic itch: emerging treatments following new research concepts","volume":"178","author":"Misery","year":"2021","journal-title":"Br J Pharmacol"},{"key":"2023010808114801800_bjd21698-bib-0008","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1111\/jdv.15107","article-title":"Prurigo nodularis: a physician survey to evaluate current perceptions of its classification, clinical experience and unmet need","volume":"32","author":"Pereira","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023010808114801800_bjd21698-bib-0009","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/jdv.14570","article-title":"European Academy of Dermatology and Venereology European Prurigo Project: expert consensus on the definition, classification and terminology of chronic prurigo","volume":"32","author":"Pereira","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"263\u20136","key":"2023010808114801800_bjd21698-bib-0010","article-title":"EADV Task Force Pruritus. Position statement: linear prurigo is a subtype of chronic prurigo","volume":"33","author":"Pereira","year":"2019","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023010808114801800_bjd21698-bib-0011","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/jdv.13296","article-title":"European EADV network on assessment of severity and burden of Pruritus (PruNet): first meeting on outcome tools","volume":"30","author":"St\u00e4nder","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023010808114801800_bjd21698-bib-0012","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-84882-322-8","volume-title":"Pruritus","author":"Misery","year":"2010"},{"key":"2023010808114801800_bjd21698-bib-0013","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1097\/j.pain.0000000000001220","article-title":"Alloknesis and hyperknesis \u2013 mechanisms, assessment methodology, and clinical implications of itch sensitization","volume":"159","author":"Andersen","year":"2018","journal-title":"Pain"},{"key":"2023010808114801800_bjd21698-bib-0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/itx.0000000000000042","article-title":"IFSI-guideline on chronic prurigo including prurigo nodularis","volume":"5","author":"St\u00e4nder","year":"2020","journal-title":"Itch"},{"key":"2023010808114801800_bjd21698-bib-0015","article-title":"Chronic prurigo: similar clinical profile and burden across clinical phenotypes","volume":"8","author":"Zeidler","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"2023010808114801800_bjd21698-bib-0016","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.jaad.2020.07.025","article-title":"Practical approaches for diagnosis and management of prurigo nodularis: United States expert panel consensus","volume":"84","author":"Elmariah","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"2023010808114801800_bjd21698-bib-0017","first-page":"e414","article-title":"2020 guidelines for the diagnosis and treatment of prurigo","volume":"48","author":"Satoh","year":"2021","journal-title":"J Dermatol"},{"key":"2023010808114801800_bjd21698-bib-0018","doi-asserted-by":"crossref","DOI":"10.2340\/00015555-3655","article-title":"Epidemiology of prurigo nodularis compared with psoriasis in Germany: a claims database analysis","volume":"100","author":"St\u00e4nder","year":"2020","journal-title":"Acta Derm Venereol"},{"key":"2023010808114801800_bjd21698-bib-0019","doi-asserted-by":"crossref","DOI":"10.2340\/00015555-3518","article-title":"Prevalence of prurigo nodularis in Poland","volume":"100","author":"Ryczek","year":"2020","journal-title":"Acta Derm Venereol"},{"key":"2023010808114801800_bjd21698-bib-0020","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1016\/j.jaip.2020.05.051","article-title":"Prevalence of prurigo nodularis in the United States","volume":"8","author":"Whang","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2023010808114801800_bjd21698-bib-0021","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jid.2019.07.697","article-title":"Real-world prevalence of prurigo nodularis and burden of associated diseases","volume":"140","author":"Huang","year":"2020","journal-title":"J Invest Dermatol"},{"key":"2023010808114801800_bjd21698-bib-0022","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jdin.2020.10.009","article-title":"Prevalence of prurigo nodularis in the United States of America: a retrospective database analysis","volume":"2","author":"St\u00e4nder S","year":"2020","journal-title":"JAAD Int"},{"key":"2023010808114801800_bjd21698-bib-0023","doi-asserted-by":"crossref","first-page":"e602","DOI":"10.1111\/jdv.17333","article-title":"Prevalence and management of chronic nodular prurigo (CNPG) in Brittany (France): estimation by matching two databases","volume":"35","author":"Misery","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023010808114801800_bjd21698-bib-0024","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1111\/jdv.17485","article-title":"Prevalence, incidence and presence of comorbidities in patients with prurigo and pruritus in Germany: a population-based claims data analysis","volume":"35","author":"Augustin","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023010808114801800_bjd21698-bib-0025","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/bjd.21032","article-title":"Epidemiology of prurigo nodularis in England: a retrospective database analysis","volume":"187","author":"Morgan","year":"2022","journal-title":"Br J Dermatol"},{"key":"2023010808114801800_bjd21698-bib-0026","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1111\/bjd.20627","article-title":"Patients with nodular prurigo commonly have pre-existing psychological disease that requires treatment concomitant with cutaneous therapies","volume":"185","author":"Pathmarajah","year":"2021","journal-title":"Br J Dermatol"},{"key":"2023010808114801800_bjd21698-bib-0027","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.jaad.2019.03.083","article-title":"Association between prurigo nodularis and malignancy in middle-aged adults","volume":"81","author":"Larson","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"2023010808114801800_bjd21698-bib-0028","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1016\/j.jid.2021.02.756","article-title":"A nationwide study of prurigo nodularis: disease burden and healthcare utilization in the United States","volume":"141","author":"Wongvibulsin","year":"2021","journal-title":"J Invest Dermatol"},{"issue":"adv00508","key":"2023010808114801800_bjd21698-bib-0029","article-title":"Comorbidities of prurigo nodularis in Finland between 1996 and 2019","volume":"101","author":"Wikstr\u00f6m","year":"2021","journal-title":"Acta Derm Venereol"},{"key":"2023010808114801800_bjd21698-bib-0030","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3390\/jcm11010095","article-title":"Epidemiology, comorbidities, and prescription patterns of Korean prurigo nodularis patients: a multi-institution study","volume":"11","author":"Woo","year":"2021","journal-title":"J Clin Med"},{"key":"2023010808114801800_bjd21698-bib-0031","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.jaad.2021.09.028","article-title":"Racial disparities in mortality among patients with prurigo nodularis: a multi-center cohort study","volume":"86","author":"Sutaria","year":"2022","journal-title":"J Am Acad Dermatol"},{"key":"2023010808114801800_bjd21698-bib-0032","doi-asserted-by":"crossref","first-page":"e225","DOI":"10.1111\/jdv.17756","article-title":"Clinical characteristics of chronic nodular prurigo are independent of Fitzpatrick skin type: a European prospective cross-sectional study","volume":"36","author":"Pereira","year":"2022","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023010808114801800_bjd21698-bib-0033","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.sder.2011.04.001","article-title":"Anatomy and neurophysiology of pruritus","volume":"30","author":"Ikoma","year":"2011","journal-title":"Semin Cutan Med Surg"},{"key":"2023010808114801800_bjd21698-bib-0034","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jid.2019.05.029","article-title":"Peripheral sensitization and loss of descending inhibition is a hallmark of chronic pruritus","volume":"140","author":"Pogatzki-Zahn","year":"2020","journal-title":"J Invest Dermatol"},{"key":"2023010808114801800_bjd21698-bib-0035","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.neuron.2010.02.025","article-title":"Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice","volume":"65","author":"Ross","year":"2010","journal-title":"Neuron"},{"key":"2023010808114801800_bjd21698-bib-0036","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s13238-017-0395-5","article-title":"TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization","volume":"8","author":"Gouin","year":"2017","journal-title":"Protein Cell"},{"key":"2023010808114801800_bjd21698-bib-0037","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.jaci.2018.09.005","article-title":"Itch: from mechanism to (novel) therapeutic approaches","volume":"142","author":"Yosipovitch","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"2023010808114801800_bjd21698-bib-0038","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/ana.25912","article-title":"Keratinocytes communicate with sensory neurons via synaptic-like contacts","volume":"88","author":"Talagas","year":"2020","journal-title":"Ann Neurol"},{"key":"2023010808114801800_bjd21698-bib-0039","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nn.3881","article-title":"Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing","volume":"18","author":"Usoskin","year":"2015","journal-title":"Nat Neurosci"},{"key":"2023010808114801800_bjd21698-bib-0040","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1016\/j.jaci.2022.02.021","article-title":"Mast cells, cortistatin, and its receptor, MRGPRX2, are linked to the pathogenesis of chronic prurigo","volume":"149","author":"Kolkhir","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"2023010808114801800_bjd21698-bib-0041","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1016\/j.neuron.2021.07.020","article-title":"Dissecting the precise nature of itch-evoked scratching","volume":"109","author":"Wimalasena","year":"2021","journal-title":"Neuron"},{"key":"2023010808114801800_bjd21698-bib-0042","article-title":"Interleukin-31 signaling bridges the gap between immune cells, the nervous system and epithelial tissues","volume":"8","author":"Nemmer","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"2023010808114801800_bjd21698-bib-0043","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/exd.14279","article-title":"Itch intensity in prurigo nodularis is closely related to dermal interleukin-31, oncostatin M, IL-31 receptor alpha and oncostatin M receptor beta","volume":"30","author":"Hashimoto","year":"2021","journal-title":"Exp Dermatol"},{"key":"2023010808114801800_bjd21698-bib-0044","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1016\/j.jid.2021.02.749","article-title":"Prurigo nodularis is characterized by systemic and cutaneous T helper 22 immune polarization","volume":"141","author":"Belzberg","year":"2021","journal-title":"J Invest Dermatol"},{"key":"2023010808114801800_bjd21698-bib-0045","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1034\/j.1600-0560.2000.027007359.x","article-title":"CGRP-immunoreactive nerves in prurigo nodularis \u2013 an exploration of neurogenic inflammation","volume":"27","author":"Liang","year":"2000","journal-title":"J Cutan Pathol"},{"key":"2023010808114801800_bjd21698-bib-0046","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jdermsci.2010.03.020","article-title":"Low density of sympathetic nerve fibers relative to substance P-positive nerve fibers in lesional skin of chronic pruritus and prurigo nodularis","volume":"58","author":"Haas","year":"2010","journal-title":"J Dermatol Sci"},{"key":"2023010808114801800_bjd21698-bib-0047","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jid.2021.10.011","article-title":"Cutaneous transcriptomics identifies fibroproliferative and neurovascular gene dysregulation in prurigo nodularis compared with psoriasis and atopic dermatitis","volume":"142","author":"Sutaria","year":"2022","journal-title":"J Invest Dermatol"},{"key":"2023010808114801800_bjd21698-bib-0048","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.jaci.2021.10.004","article-title":"Transcriptomic characterization of prurigo nodularis and the therapeutic response to nemolizumab","volume":"149","author":"Tsoi","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"2023010808114801800_bjd21698-bib-0049","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1111\/jdv.15040","article-title":"Prurigo Activity Score (PAS): validity and reliability of a new instrument to monitor chronic prurigo","volume":"32","author":"P\u00f6lking","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023010808114801800_bjd21698-bib-0050","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1001\/jamadermatol.2020.3071","article-title":"Validation of psychometric properties of the itch numeric rating scale for pruritus associated with prurigo nodularis: a secondary analysis of a randomized clinical trial","volume":"156","author":"Kimel","year":"2020","journal-title":"JAMA Dermatol"},{"key":"2023010808114801800_bjd21698-bib-0051","doi-asserted-by":"crossref","DOI":"10.2340\/00015555-3701","article-title":"Investigator\u2019s Global Assessment of Chronic Prurigo: a new instrument for use in clinical trials","volume":"101","author":"Zeidler","year":"2021","journal-title":"Acta Derm Venereol"},{"key":"2023010808114801800_bjd21698-bib-0052","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/jdv.16929","article-title":"The burden in chronic prurigo: patients with chronic prurigo suffer more than patients with chronic pruritus on non-lesional skin: a comparative, retrospective, explorative statistical analysis of 4,484 patients in a real-world cohort","volume":"35","author":"Zeidler","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023010808114801800_bjd21698-bib-0053","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1111\/jdv.16309","article-title":"Chronic nodular prurigo: clinical profile and burden. A European cross-sectional study","volume":"34","author":"Pereira","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023010808114801800_bjd21698-bib-0054","doi-asserted-by":"crossref","first-page":"e297","DOI":"10.1111\/jdv.17777","article-title":"One third of chronic prurigo patients scratch automatically and in the absence of itch \u2013 a naturalistic study of 1142 patients","volume":"36","author":"Schneider","year":"2022","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023010808114801800_bjd21698-bib-0055","doi-asserted-by":"crossref","first-page":"e815","DOI":"10.1111\/jdv.16696","article-title":"The impact of prurigo nodularis on sleep disturbance and related impact: a systematic review","volume":"34","author":"Gwillim","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023010808114801800_bjd21698-bib-0056","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00403-020-02148-0","article-title":"The impact of prurigo nodularis on quality of life: a systematic review and meta-analysis","volume":"313","author":"Janmohamed","year":"2021","journal-title":"Arch Dermatol Res"},{"key":"2023010808114801800_bjd21698-bib-0057","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/jdv.15145","article-title":"The self-assessed psychological comorbidities of prurigo in European patients: a multicentre study in 13 countries","volume":"33","author":"Brenaut","year":"2019","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023010808114801800_bjd21698-bib-0058","doi-asserted-by":"crossref","first-page":"478","DOI":"10.2340\/00015555-2561","article-title":"Impairment of sexual life in 3,485 dermatological outpatients from a multicentre study in 13 European countries","volume":"97","author":"Sampogna","year":"2017","journal-title":"Acta Derm Venereol"},{"key":"2023010808114801800_bjd21698-bib-0059","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1365-2133.2005.06852.x","article-title":"Psychological factors in prurigo nodularis in comparison with psoriasis vulgaris: results of a case\u2013control study","volume":"154","author":"Schneider","year":"2006","journal-title":"Br J Dermatol"},{"key":"2023010808114801800_bjd21698-bib-0060","doi-asserted-by":"crossref","first-page":"e239","DOI":"10.1111\/jdv.16973","article-title":"Chronic prurigo patients do not report higher impulsiveness or more traumatic life experiences than chronic pruritus patients with non-lesional skin","volume":"35","author":"Schneider","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"adv00217","key":"2023010808114801800_bjd21698-bib-0061","article-title":"Delusional infestation can be a complication of prurigo nodularis with underlying neuropathies","volume":"100","author":"Dervout","year":"2020","journal-title":"Acta Derm Venereol"},{"key":"2023010808114801800_bjd21698-bib-0062","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jaad.2021.05.036","article-title":"Health-related quality of life and economic burden of prurigo nodularis","volume":"86","author":"Whang","year":"2022","journal-title":"J Am Acad Dermatol"},{"key":"2023010808114801800_bjd21698-bib-0063","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.jaad.2018.09.020","article-title":"A systematic review of evidence-based treatments for prurigo nodularis","volume":"80","author":"Qureshi","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"2023010808114801800_bjd21698-bib-0064","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3390\/medicina56110599","article-title":"Oral alitretinoin for patients with refractory prurigo","volume":"56","author":"Chung","year":"2020","journal-title":"Medicina (Kaunas)"},{"key":"2023010808114801800_bjd21698-bib-0065","doi-asserted-by":"crossref","first-page":"e516","DOI":"10.1111\/jdv.17262","article-title":"Combined methotrexate and alitretinoin for the treatment of difficult-to-treat generalized prurigo nodularis: a case series","volume":"35","author":"Bergqvist","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"adv00118","key":"2023010808114801800_bjd21698-bib-0066","article-title":"Efficacy of apremilast in patients with prurigo nodularis: a proof-of-concept study","volume":"100","author":"Todberg","year":"2020","journal-title":"Acta Derm Venereol"},{"key":"2023010808114801800_bjd21698-bib-0067","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2340\/00015555-1400","article-title":"European Guideline on Chronic Pruritus","volume":"92","author":"Weisshaar","year":"2012","journal-title":"Acta Derm Venereol"},{"key":"2023010808114801800_bjd21698-bib-0068","doi-asserted-by":"crossref","DOI":"10.2340\/00015555-3726","article-title":"Chronic nodular prurigo: a European cross-sectional study of patient perspectives on therapeutic goals and satisfaction","volume":"101","author":"Pereira","year":"2021","journal-title":"Acta Derm Venereol"},{"key":"2023010808114801800_bjd21698-bib-0069","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.jaad.2019.01.052","article-title":"Serlopitant reduced pruritus in patients with prurigo nodularis in a phase 2, randomized, placebo-controlled trial","volume":"80","author":"St\u00e4nder","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"2023010808114801800_bjd21698-bib-0070","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jaad.2018.02.030","article-title":"Serlopitant for the treatment of chronic pruritus: results of a randomized, multicenter, placebo-controlled phase 2 clinical trial","volume":"78","author":"Yosipovitch","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"2023010808114801800_bjd21698-bib-0071","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172702","article-title":"Nalbuphine, a kappa opioid receptor agonist and mu opioid receptor antagonist attenuates pruritus, decreases IL-31, and increases IL-10 in mice with contact dermatitis","volume":"864","author":"Inan","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"2023010808114801800_bjd21698-bib-0072","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/jdv.17816","article-title":"Efficacy and safety of oral nalbuphine extended release in prurigo nodularis: results of a phase 2 randomized controlled trial with an open-label extension phase","volume":"36","author":"Weisshaar","year":"2022","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023010808114801800_bjd21698-bib-0073","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1056\/NEJMoa1908316","article-title":"Trial of nemolizumab in moderate-to-severe prurigo nodularis","volume":"382","author":"St\u00e4nder","year":"2020","journal-title":"N Engl J Med"},{"key":"2023010808114801800_bjd21698-bib-0074","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1111\/jdv.15957","article-title":"Effectiveness and safety of dupilumab for the treatment of prurigo nodularis in a French multicenter adult cohort of 16 patients","volume":"34","author":"Calugareanu","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023010808114801800_bjd21698-bib-0075","doi-asserted-by":"crossref","DOI":"10.1111\/jdv.18221","article-title":"Efficacy of dupilumab in chronic prurigo and chronic idiopathic pruritus: a systematic review of current evidence and analysis of response predictors","author":"Gael","year":"2022","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023010808114801800_bjd21698-bib-0076","first-page":"1","article-title":"Therapeutic potential of biologics in prurigo nodularis","volume":"4","author":"M\u00fcller","year":"2021","journal-title":"Expert Opin Biol Ther"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjd.21698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjd.21698","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/187\/4\/464\/48529333\/bjd0464.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/187\/4\/464\/48529333\/bjd0464.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T14:13:31Z","timestamp":1676384011000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/187\/4\/464\/6966235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,1]]},"references-count":76,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,10,1]]},"published-print":{"date-parts":[[2022,10,1]]}},"URL":"https:\/\/doi.org\/10.1111\/bjd.21698","relation":{},"ISSN":["1365-2133","0007-0963"],"issn-type":[{"value":"1365-2133","type":"electronic"},{"value":"0007-0963","type":"print"}],"subject":[],"published-other":{"date-parts":[[2022,10,1]]},"published":{"date-parts":[[2022,10,1]]},"assertion":[{"value":"2022-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}