{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:11:10Z","timestamp":1793459470719,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T00:00:00Z","timestamp":1673049600000},"content-version":"vor","delay-in-days":37,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005897","name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie et de Pathologie Sexuellement Transmissible","doi-asserted-by":"publisher","award":["SFD AO 2015"],"award-info":[{"award-number":["SFD AO 2015"]}],"id":[{"id":"10.13039\/501100005897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005897","name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie et de Pathologie Sexuellement Transmissible","doi-asserted-by":"publisher","award":["SFD AO 2015"],"award-info":[{"award-number":["SFD AO 2015"]}],"id":[{"id":"10.13039\/501100005897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary cutaneous peripheral T-cell lymphomas with a T-follicular helper phenotype (pcTFH-PTCL) are poorly characterized, and often compared to, but not corresponding with, mycosis fungoides (MF), S\u00e9zary syndrome, primary cutaneous CD4+ lymphoproliferative disorder, and skin manifestations of angioimmunoblastic T-cell lymphomas (AITL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We describe the clinicopathological features of pcTFH-PTCL in this original series of 23 patients, and also characterize these cases molecularly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical and histopathological data of the selected patients were reviewed. Patient biopsy samples were also analysed by targeted next-generation sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients (15 men, eight women; median age 66 years) presented with skin lesions, without systemic disease. Most were stage T3b, with nodular (n = 16), papular (n = 6) or plaque (atypical for MF, n = 1) lesions. Three (13%) developed systemic disease and died of lymphoma. Nine (39%) patients received more than one line of chemotherapy. Histologically, the lymphomas were CD4+ T-cell proliferations, usually dense and located in the deep dermis (n = 14, 61%), with the expression of at least two TFH markers (CD10, CXCL13, PD1, ICOS, BCL6), including three markers in 16 cases (70%). They were associated with a variable proportion of B cells. Eight patients were diagnosed with an associated B-cell lymphoproliferative disorder (LPD) on biopsy, including Epstein\u2013Barr virus (EBV)-positive diffuse large B-cell lymphoma (n = 3), EBV+ LPD (n = 1) and monotypic plasma cell LPD (n = 4). Targeted sequencing showed four patients to have a mutated TET2\u2013RHOAG17V association (as frequently seen in AITL) and another a TET2\/DNMT3A\/PLCG1\/SETD2 mutational profile. The latter patient, one with a TET2\u2013RHOA association, and one with no detected mutations, developed systemic disease and died. Five other patients showed isolated mutations in TET2 (n = 1), PLCG1 (n = 2), SETD2 (n = 1) or STAT5B (n = 1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with pcTFH-PTCL have pathological and genetic features that overlap with those of systemic lymphoma of TFH derivation. Clinically, most remained confined to the skin, with only three patients showing systemic spread and death. Whether pcTFH-PTCL should be integrated as a new subgroup of TFH lymphomas in future classifications is still a matter of debate.<\/jats:p><jats:p>What is already known about this topic? \u00a0There is a group of cutaneous lymphomas that express T-follicular helper (TFH) markers that do not appear to correspond to existing World Health Organization diagnostic entities.These include mycosis fungoides, S\u00e9zary syndrome, or primary cutaneous CD4+ small\/medium-sized T-cell lymphoproliferative disorder or cutaneous extensions of systemic peripheral T-cell lymphomas (PTCL) with TFH phenotype.<\/jats:p><jats:p>What does this study add? \u00a0This is the first large original series of patients with a diagnosis of primary cutaneous PTCL with a TFH phenotype (pcTFH-PTCL) to be molecularly characterized.pcTFH-PTCL may be a standalone group of cutaneous lymphomas with clinicopathological and molecular characteristics that overlap with those of systemic TFH lymphomas, such as angioimmunoblastic T-cell lymphoma, and does not belong to known diagnostic groups of cutaneous lymphoma.This has an impact on the treatment and follow-up of patients; the clinical behaviour needs to be better clarified in further studies to tailor patient management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bjd.21791","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T16:43:52Z","timestamp":1658940232000},"page":"970-980","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Primary cutaneous peripheral T-cell lymphomas with a T-follicular helper phenotype: an integrative clinical, pathological and molecular case series study"],"prefix":"10.1093","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8226-6432","authenticated-orcid":false,"given":"Luojun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology Assistance Publique \u2013 H\u00f4pitaux de Paris, Henri-Mondor Hospital 94010 Cr\u00e9teil France"},{"name":"INSERM U955 Institut Mondor de Recherche Biom\u00e9dicale (IMRB) Paris Est Cr\u00e9teil University 94010 Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Rocas","sequence":"additional","affiliation":[{"name":"Department of Pathology Lyon Sud, Pierre-B\u00e9nite Hospital 69495 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Dalle","sequence":"additional","affiliation":[{"name":"Department of Dermatology Lyon Sud, Pierre-B\u00e9nite Hospital 69495 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouhoum","family":"Sako","sequence":"additional","affiliation":[{"name":"INSERM U955 Institut Mondor de Recherche Biom\u00e9dicale (IMRB) Paris Est Cr\u00e9teil University 94010 Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pelletier","sequence":"additional","affiliation":[{"name":"INSERM U955 Institut Mondor de Recherche Biom\u00e9dicale (IMRB) Paris Est Cr\u00e9teil University 94010 Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Martin","sequence":"additional","affiliation":[{"name":"INSERM U955 Institut Mondor de Recherche Biom\u00e9dicale (IMRB) Paris Est Cr\u00e9teil University 94010 Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Dupuy","sequence":"additional","affiliation":[{"name":"INSERM U955 Institut Mondor de Recherche Biom\u00e9dicale (IMRB) Paris Est Cr\u00e9teil University 94010 Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Tazi","sequence":"additional","affiliation":[{"name":"Department of Pathology Assistance Publique \u2013 H\u00f4pitaux de Paris, Henri-Mondor Hospital 94010 Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Balme","sequence":"additional","affiliation":[{"name":"Department of Pathology Lyon Sud, Pierre-B\u00e9nite Hospital 69495 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Vergier","sequence":"additional","affiliation":[{"name":"Department of Pathology CHU de Bordeaux, Haut-L\u00e9v\u00eaque Hospital 33600 Pessac France"},{"name":"INSERM, U1312 Universit\u00e9 de Bordeaux 33000 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6150-1229","authenticated-orcid":false,"given":"Marie","family":"Beylot-Barry","sequence":"additional","affiliation":[{"name":"INSERM, U1312 Universit\u00e9 de Bordeaux 33000 Bordeaux France"},{"name":"Department of Dermatology CHU de Bordeaux, Saint-Andr\u00e9 Hospital 33000 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Carlotti","sequence":"additional","affiliation":[{"name":"Department of Pathology Assistance Publique \u2013 H\u00f4pitaux de Paris, Cochin Hospital 75014 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1631-5192","authenticated-orcid":false,"given":"Martine","family":"Bagot","sequence":"additional","affiliation":[{"name":"Department of Dermatology Assistance Publique \u2013 H\u00f4pitaux de Paris, Saint-Louis Hospital, 75010, Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Battistella","sequence":"additional","affiliation":[{"name":"Department of Pathology Assistance Publique \u2013 H\u00f4pitaux de Paris, Saint-Louis Hospital, 75010, Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0172-2892","authenticated-orcid":false,"given":"Guillaume","family":"Chaby","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU d\u2019Amiens-Picardie, H\u00f4pital Sud 80054 Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5383-7096","authenticated-orcid":false,"given":"Saskia","family":"Ingen-Housz-Oro","sequence":"additional","affiliation":[{"name":"Department of Dermatology Assistance Publique \u2013 H\u00f4pitaux de Paris, Henri-Mondor Hospital 94010 Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gaulard","sequence":"additional","affiliation":[{"name":"Department of Pathology Assistance Publique \u2013 H\u00f4pitaux de Paris, Henri-Mondor Hospital 94010 Cr\u00e9teil France"},{"name":"INSERM U955 Institut Mondor de Recherche Biom\u00e9dicale (IMRB) Paris Est Cr\u00e9teil University 94010 Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0111-7422","authenticated-orcid":false,"given":"Nicolas","family":"Ortonne","sequence":"additional","affiliation":[{"name":"Department of Pathology Assistance Publique \u2013 H\u00f4pitaux de Paris, Henri-Mondor Hospital 94010 Cr\u00e9teil France"},{"name":"INSERM U955 Institut Mondor de Recherche Biom\u00e9dicale (IMRB) Paris Est Cr\u00e9teil University 94010 Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"2023010808112417400_bjd21791-bib-0001","volume-title":"Revised","author":"Swerdlow","year":"2017","edition":"4th edition"},{"key":"2023010808112417400_bjd21791-bib-0002","doi-asserted-by":"crossref","first-page":"e148","DOI":"10.3324\/haematol.2016.158428","article-title":"Integrative clinicopathological and molecular analyses of angioimmunoblastic T-cell lymphoma and other nodal lymphomas of follicular helper T-cell origin","volume":"102","author":"Dobay","year":"2017","journal-title":"Haematologica"},{"key":"2023010808112417400_bjd21791-bib-0003","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1097\/PAS.0000000000000956","article-title":"Expression of TFH markers and detection of RHOA p.G17V and IDH2 p.R172K\/S mutations in cutaneous localizations of angioimmunoblastic T-cell lymphomas","volume":"41","author":"Leclaire Alirkilicarslan","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"2023010808112417400_bjd21791-bib-0004","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/DAD.0b013e31821c35cb","article-title":"Expression patterns of the immunosuppressive proteins PD-1\/CD279 and PD-L1\/CD274 at different stages of cutaneous T-cell lymphoma\/mycosis fungoides","volume":"34","author":"Kantekure","year":"2012","journal-title":"Am J Dermatopathol"},{"key":"2023010808112417400_bjd21791-bib-0005","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/cup.12204","article-title":"Primary cutaneous follicular helper T-cell lymphoma: diagnostic pitfalls of this new lymphoma subtype","volume":"40","author":"Buder","year":"2013","journal-title":"J Cutan Pathol"},{"key":"2023010808112417400_bjd21791-bib-0006","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/modpathol.2012.124","article-title":"Follicular center helper T-cell (TFH) marker positive mycosis fungoides\/Sezary syndrome","volume":"26","author":"Meyerson","year":"2013","journal-title":"Mod Pathol"},{"key":"2023010808112417400_bjd21791-bib-0007","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/DAD.0000000000000258","article-title":"Expression of T-follicular helper markers in sequential biopsies of progressive mycosis fungoides and other primary cutaneous T-cell lymphomas","volume":"37","author":"Bosisio","year":"2015","journal-title":"Am J Dermatopathol"},{"key":"2023010808112417400_bjd21791-bib-0008","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1200\/JCO.2008.16.1307","article-title":"Primary cutaneous small\/medium CD4+ T-cell lymphomas: a heterogeneous group of tumors with different clinicopathologic features and outcome","volume":"26","author":"Garcia-Herrera","year":"2008","journal-title":"J Clin Oncol"},{"key":"2023010808112417400_bjd21791-bib-0009","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/PAS.0b013e31818e52fe","article-title":"Primary cutaneous CD4+ small\/medium-sized pleomorphic T-cell lymphoma expresses follicular T-cell markers","volume":"33","author":"Rodr\u00edguez Pinilla","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"2023010808112417400_bjd21791-bib-0010","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/PAS.0b013e318230df87","article-title":"Expression of programmed death-1 in primary cutaneous CD4-positive small\/medium-sized pleomorphic T-cell lymphoma, cutaneous pseudo-T-cell lymphoma, and other types of cutaneous T-cell lymphoma","volume":"36","author":"Cetin\u00f6zman","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"2023010808112417400_bjd21791-bib-0011","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1111\/cup.12234","article-title":"Evaluation of follicular T-helper cells in primary cutaneous CD4+ small\/medium pleomorphic T-cell lymphoma and dermatitis","volume":"40","author":"Ally","year":"2013","journal-title":"J Cutan Pathol"},{"key":"2023010808112417400_bjd21791-bib-0012","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1097\/PAS.0000000000001470","article-title":"Primary cutaneous CD4+ small\/medium T-cell lymphoproliferative disorders: a clinical, pathologic, and molecular study of 60 cases presenting with a single lesion: a multicenter study of the French Cutaneous Lymphoma Study Group","volume":"44","author":"Beltzung","year":"2020","journal-title":"Am J Surg Pathol"},{"key":"2023010808112417400_bjd21791-bib-0013","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1365-2559.2010.03498.x","article-title":"Primary cutaneous follicular variant of peripheral T-cell lymphoma NOS. A report of two cases","volume":"56","author":"Le Tourneau","year":"2010","journal-title":"Histopathology"},{"key":"2023010808112417400_bjd21791-bib-0014","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1001\/archdermatol.2011.3269","article-title":"Primary cutaneous follicular helper T-cell lymphoma: a new subtype of cutaneous T-cell lymphoma reported in a series of 5 cases","volume":"148","author":"Battistella","year":"2012","journal-title":"Arch Dermatol"},{"key":"2023010808112417400_bjd21791-bib-0015","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2340\/00015555-1626","article-title":"Primary cutaneous follicular helper T-cell lymphoma treated with allogeneic bone marrow transplantation: immunohistochemical comparison with angioimmunoblastic T-cell lymphoma","volume":"94","author":"Ohmatsu","year":"2014","journal-title":"Acta Derm Venereol"},{"key":"2023010808112417400_bjd21791-bib-0016","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1097\/DAD.0000000000000695","article-title":"Primary cutaneous follicular helper T-cell lymphoma: a case series and review of the literature","volume":"39","author":"Wang","year":"2017","journal-title":"Am J Dermatopathol"},{"key":"2023010808112417400_bjd21791-bib-0017","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1182\/blood-2006-10-054601","article-title":"TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the Cutaneous Lymphoma Task Force of the European Organization of Research and Treatment of Cancer (EORTC)","volume":"110","author":"Kim","year":"2007","journal-title":"Blood"},{"key":"2023010808112417400_bjd21791-bib-0018","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/(SICI)1096-9896(199802)184:2<185::AID-PATH997>3.0.CO;2-9","article-title":"Value of clonality studies of cutaneous T lymphocytes in the diagnosis and follow-up of patients with mycosis fungoides","volume":"184","author":"Delfau-Larue","year":"1998","journal-title":"J Pathol"},{"key":"2023010808112417400_bjd21791-bib-0019","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.jmoldx.2018.05.012","article-title":"Multiple ways to detect IDH2 mutations in angioimmunoblastic T-cell lymphoma from immunohistochemistry to next-generation sequencing","volume":"20","author":"Dupuy","year":"2018","journal-title":"J Mol Diagn"},{"key":"2023010808112417400_bjd21791-bib-0020","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.21105\/joss.02630","article-title":"StatAid: an R package with a graphical user interface for data analysis","volume":"5","author":"Alcazer","year":"2020","journal-title":"J Open Source Softw"},{"key":"2023010808112417400_bjd21791-bib-0021","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/ng.2872","article-title":"Somatic RHOA mutation in angioimmunoblastic T cell lymphoma","volume":"46","author":"Sakata-Yanagimoto","year":"2014","journal-title":"Nat Genet"},{"key":"2023010808112417400_bjd21791-bib-0022","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1309\/6UTX-GVC0-12ND-JJEU","article-title":"Epstein\u2013Barr virus-associated B-cell lymphoproliferative disorders in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified","volume":"117","author":"Zettl","year":"2002","journal-title":"Am J Clin Pathol"},{"key":"2023010808112417400_bjd21791-bib-0023","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1097\/PAS.0b013e3180339f18","article-title":"Epstein\u2013Barr virus negative clonal plasma cell proliferations and lymphomas in peripheral T-cell lymphomas: a phenomenon with distinctive clinicopathologic features","volume":"31","author":"Balagu\u00e9","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"2023010808112417400_bjd21791-bib-0024","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1053\/j.semdp.2011.03.003","article-title":"Follicular helper T cells: implications in neoplastic hematopathology","volume":"28","author":"Gaulard","year":"2011","journal-title":"Semin Diagn Pathol"},{"key":"2023010808112417400_bjd21791-bib-0025","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3324\/haematol.2020.265991","article-title":"Early detection of T-cell lymphoma with T follicular helper phenotype by RHOA mutation analysis","volume":"107","author":"Dobson","year":"2021","journal-title":"Haematologica"},{"key":"2023010808112417400_bjd21791-bib-0026","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/ng.2873","article-title":"Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas","volume":"46","author":"Palomero","year":"2014","journal-title":"Nat Genet"},{"key":"2023010808112417400_bjd21791-bib-0027","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1038\/ng.3442","article-title":"The mutational landscape of cutaneous T cell lymphoma and S\u00e9zary syndrome","volume":"47","author":"da Silva Almeida","year":"2015","journal-title":"Nat Genet"},{"key":"2023010808112417400_bjd21791-bib-0028","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/ng.3370","article-title":"Genomic analysis of mycosis fungoides and S\u00e9zary syndrome identifies recurrent alterations in TNFR2","volume":"47","author":"Ungewickell","year":"2015","journal-title":"Nat Genet"},{"key":"2023010808112417400_bjd21791-bib-0029","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/ng.3356","article-title":"Genomic landscape of cutaneous T cell lymphoma","volume":"47","author":"Choi","year":"2015","journal-title":"Nat Genet"},{"key":"2023010808112417400_bjd21791-bib-0030","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1182\/blood-2016-02-699843","article-title":"Candidate driver genes involved in genome maintenance and DNA repair in S\u00e9zary syndrome","volume":"127","author":"Woollard","year":"2016","journal-title":"Blood"},{"key":"2023010808112417400_bjd21791-bib-0031","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.3324\/haematol.2014.113696","article-title":"Recurrent presence of the PLCG1 S345F mutation in nodal peripheral T-cell lymphomas","volume":"100","author":"Manso","year":"2015","journal-title":"Haematologica"},{"key":"2023010808112417400_bjd21791-bib-0032","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/ng.3415","article-title":"Integrated molecular analysis of adult T cell leukemia\/lymphoma","volume":"47","author":"Kataoka","year":"2015","journal-title":"Nat Genet"},{"key":"2023010808112417400_bjd21791-bib-0033","doi-asserted-by":"crossref","first-page":"17763","DOI":"10.18632\/oncotarget.14846","article-title":"Angioimmunoblastic T cell lymphoma: novel molecular insights by mutation profiling","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"2023010808112417400_bjd21791-bib-0034","doi-asserted-by":"crossref","first-page":"12602","DOI":"10.1038\/ncomms12602","article-title":"Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations","volume":"7","author":"Roberti","year":"2016","journal-title":"Nat Commun"},{"key":"2023010808112417400_bjd21791-bib-0035","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1158\/2159-8290.CD-16-0330","article-title":"The genetic basis of hepatosplenic T-cell lymphoma","volume":"7","author":"McKinney","year":"2017","journal-title":"Cancer Discov"},{"key":"2023010808112417400_bjd21791-bib-0036","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3324\/haematol.2017.182444","article-title":"Histone modifier gene mutations in peripheral T-cell lymphoma not otherwise specified","volume":"103","author":"Ji","year":"2018","journal-title":"Haematologica"},{"key":"2023010808112417400_bjd21791-bib-0037","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1182\/bloodadvances.2020002396","article-title":"T follicular helper phenotype predicts response to histone deacetylase inhibitors in relapsed\/refractory peripheral T-cell lymphoma","volume":"4","author":"Ghione","year":"2020","journal-title":"Blood Adv"},{"key":"2023010808112417400_bjd21791-bib-0038","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1200\/JCO.21.01815","article-title":"Romidepsin plus CHOP versus CHOP in patients with previously untreated peripheral T-cell lymphoma: results of the Ro-CHOP phase III study (conducted by LYSA)","volume":"40","author":"Bachy","year":"2022","journal-title":"J Clin Oncol"},{"key":"2023010808112417400_bjd21791-bib-0039","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1182\/blood-2018-04-840538","article-title":"Treatment with 5-azacytidine induces a sustained response in patients with angioimmunoblastic T-cell lymphoma","volume":"132","author":"Lemonnier","year":"2018","journal-title":"Blood"},{"key":"2023010808112417400_bjd21791-bib-0040","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1182\/blood.2020009004","article-title":"Combined oral 5-azacytidine and romidepsin are highly effective in patients with PTCL: a multicenter phase 2 study","volume":"137","author":"Falchi","year":"2021","journal-title":"Blood"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjd.21791","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjd.21791","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/187\/6\/970\/48529325\/bjd0970.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/187\/6\/970\/48529325\/bjd0970.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T01:19:04Z","timestamp":1700875144000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/187\/6\/970\/6972496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,12,1]]},"published-print":{"date-parts":[[2022,12,1]]}},"URL":"https:\/\/doi.org\/10.1111\/bjd.21791","relation":{},"ISSN":["1365-2133","0007-0963"],"issn-type":[{"value":"1365-2133","type":"electronic"},{"value":"0007-0963","type":"print"}],"subject":[],"published-other":{"date-parts":[[2022,12,1]]},"published":{"date-parts":[[2022,12,1]]},"assertion":[{"value":"2022-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}