{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T21:13:55Z","timestamp":1791753235564,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T00:00:00Z","timestamp":1344470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We present data from a phase II study investigating a novel treatment strategy for relapsed\/refractory mantle cell lymphoma (<jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>). Twenty\u2010six patients received lenalidomide 25\u00a0mg\/d (days 1\u201321 of a 28\u2010d cycle) for up to 6 cycles followed by low\u2010dose maintenance lenalidomide (15\u00a0mg) in responding patients. Eight patients achieved complete or partial response to give an overall response rate of 31% with median response duration of 22\u00b72\u00a0months [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 0\u00b70\u201353\u00b76] and median progression\u2010free survival (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>) of 3\u00b79\u00a0months (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0\u00b70\u201311\u00b71). An additional six patients (23%) achieved stable disease. Eleven patients received maintenance with median <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> of 14\u00b76\u00a0months (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 7\u00b73\u201321\u00b79). Correlative studies showed that peripheral <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>atural <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>iller (<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>) cells increased in responding patients by 40\u201360% over the first 6 cycles with an initial dip in <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells suggestive of tumour infiltration. Peripheral regulatory <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells were increased in <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001) and expanded further following lenalidomide. Sequential plasma analysis showed increased <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>12 p40 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>7 alongside decreased <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>9, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>10, and adiponectin. Finally, a significant correlation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702) between gender and response suggested that female <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> patients were more sensitive to lenalidomide than males. In summary, we confirm the activity, safety and immunomodulatory properties of lenalidomide in <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> and highlight its potential as a low\u2010dose maintenance agent.<\/jats:p>","DOI":"10.1111\/bjh.12008","type":"journal-article","created":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T12:29:34Z","timestamp":1344515374000},"page":"154-163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Single\u2010agent lenalidomide in relapsed\/refractory mantle cell lymphoma: results from a <scp>UK<\/scp> phase II study suggest activity and possible gender differences"],"prefix":"10.1111","volume":"159","author":[{"given":"Heather E.","family":"Eve","sequence":"first","affiliation":[{"name":"Department of Haematology Derriford Hospital Plymouth UK"},{"name":"Peninsula College of Medicine &amp; Dentistry University of Plymouth Plymouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Carey","sequence":"additional","affiliation":[{"name":"Department of Immunology Derriford Hospital Plymouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Peninsula College of Medicine &amp; Dentistry University of Plymouth Plymouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla C.","family":"Heise","sequence":"additional","affiliation":[{"name":"Celgene Corporation Summit NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya","family":"Mamidipudi","sequence":"additional","affiliation":[{"name":"Celgene Corporation Summit NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Shi","sequence":"additional","affiliation":[{"name":"Celgene Corporation Summit NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Radford","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Christie Hospital Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Auer","sequence":"additional","affiliation":[{"name":"Centre of Haemato\u2010Oncology Barts &amp; The London School of Medicine London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila H.","family":"Bullard","sequence":"additional","affiliation":[{"name":"R&amp;D Department Derriford Hospital Plymouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon A. 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