{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:25:04Z","timestamp":1791570304541,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T00:00:00Z","timestamp":1345766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This international retrospective study of 593 <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>plenic <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arginal <jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content>one <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ymphoma (<jats:styled-content style=\"fixed-case\">SMZL<\/jats:styled-content>) patients aimed to identify factors that determine treatment initiation and influence lymphoma\u2010specific survival (<jats:styled-content style=\"fixed-case\">LSS<\/jats:styled-content>). Logistic regression was used to identify the factors associated with treatment. A Cox regression was used to analyse <jats:styled-content style=\"fixed-case\">LSS<\/jats:styled-content> in a derivation cohort of 366 patients. This produced a prognostic index (<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>) and enabled the identification of three risk groups. The resulting stratification was validated in another cohort of 227 patients and compared with the Interguppo Italiano Linfomi (<jats:styled-content style=\"fixed-case\">IIL<\/jats:styled-content>) score in the group of 450 patients for whom all the required data were available using an extension of the net reclassification improvement. Haemoglobin concentration (<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b), extrahilar lymphadenopathy and hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> virus status were associated with the initiation of treatment. <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b, platelet count, high lactate dehydrogenase level and extrahilar lymphadenopathy were independently associated with <jats:styled-content style=\"fixed-case\">LSS<\/jats:styled-content>. Three risk groups with significantly different five\u2010year <jats:styled-content style=\"fixed-case\">LSS<\/jats:styled-content> (94%, 78% and 69%, respectively) were identified. This stratification (named <jats:styled-content style=\"fixed-case\">HPLL<\/jats:styled-content> on the basis of determinant factors) had a better discriminative power than the <jats:styled-content style=\"fixed-case\">IIL<\/jats:styled-content> score. This system is useful for stratifying <jats:styled-content style=\"fixed-case\">SMZL<\/jats:styled-content> patients into risk groups and may help in the selection of risk\u2010tailored treatment approaches.<\/jats:p>","DOI":"10.1111\/bjh.12011","type":"journal-article","created":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T12:15:21Z","timestamp":1345810521000},"page":"164-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Risk stratification for <scp>S<\/scp>plenic <scp>M<\/scp>arginal <scp>Z<\/scp>one <scp>L<\/scp>ymphoma based on haemoglobin concentration, platelet count, high lactate dehydrogenase level and extrahilar lymphadenopathy: development and validation on 593 cases"],"prefix":"10.1111","volume":"159","author":[{"given":"Carlos","family":"Montalb\u00e1n","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hospital Ramon y Cajal IRYCIS Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Abraira","sequence":"additional","affiliation":[{"name":"Clinical Biostatistics Unit Hospital Ramon y Cajal IRYCIS Madrid Spain"},{"name":"CIBERESP Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Arcaini","sequence":"additional","affiliation":[{"name":"Division of Haematology University of Pavia Medical School Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Domingo\u2010Domenech","sequence":"additional","affiliation":[{"name":"Hospital Duran i Reynals ICO Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Guisado\u2010Vasco","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Ramon y Cajal IRYCIS Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Iannito","sequence":"additional","affiliation":[{"name":"Department of Haematology Ospedale S.G. Moscati ASL Taranto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Mollejo","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Virgen de la Salud Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estella","family":"Matutes","sequence":"additional","affiliation":[{"name":"Department of Haemato\u2010Oncology Royal Marsden Hospital\/Institute of Cancer London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Ferreri","sequence":"additional","affiliation":[{"name":"Unit of Lymphoid Malignancies San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Salar","sequence":"additional","affiliation":[{"name":"Department of Haematology Hospital del Mar Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Rattotti","sequence":"additional","affiliation":[{"name":"Division of Haematology University of Pavia Medical School Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Carpaneto","sequence":"additional","affiliation":[{"name":"UOC Ematologia Ospedale Sant'Anna Ronciglione  Viterbo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"P\u00e9rez Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Oncology Hospital Gregorio Mara\u00f1on Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"Bello","sequence":"additional","affiliation":[{"name":"Department of Haematology Hospital Universitario, Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Haematology Hospital Universitario de Canarias Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Caballero","sequence":"additional","affiliation":[{"name":"Department of Haematology Hospital Cl\u00ednico Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Carbonell","sequence":"additional","affiliation":[{"name":"Hospital General Universitari Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Piris","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Marques de Valdecilla Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Splenic Marginal Zone Lymphoma Study Group (SMZLSG)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b605"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11893"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-11-4659"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.5.1648.h81702001648_1648_1654"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.7326\/0003-4819-150-11-200906020-00007","article-title":"Advances in measuring the effect of individual predictors of cardiovascular risk: the role of reclassification measures","volume":"150","author":"Cook N.R.","year":"2009","journal-title":"Annals of Internal Medicine"},{"key":"e_1_2_7_7_1","volume-title":"Applied Survival Analysis: Regression Modeling of Time to Event Data","author":"Hosmer D.W.","year":"1999"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.013714"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2405068"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04165.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4085"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","DOI":"10.1002\/9780470770771","volume-title":"Multivariable Model\u2010Building. 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