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Among the major toxicities associated with <jats:sc>l<\/jats:sc>\u2010asparaginase therapy are pancreatitis, allergic reactions, thrombotic events, hepatotoxicity and hyperlipidaemia. Acute pancreatitis is one of the most common reasons for stopping treatment with <jats:sc>l<\/jats:sc>\u2010asparaginase. Short\u2010term complications of asparaginase\u2010associated pancreatitis include development of pseudocysts and pancreatic necrosis. Long\u2010term complications include chronic pancreatitis and diabetes. The pathophysiology of asparaginase\u2010associated pancreatitis remains to be uncovered. Individual clinical and genetic risk factors have been identified, but they are only weak predictors of pancreatitis. This review explores the definition, possible risk factors, treatment and complications of asparaginase\u2010associated pancreatitis.<\/jats:p>","DOI":"10.1111\/bjh.12016","type":"journal-article","created":{"date-parts":[[2012,8,22]],"date-time":"2012-08-22T12:07:48Z","timestamp":1345637268000},"page":"18-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":119,"title":["Asparaginase\u2010associated pancreatitis in children"],"prefix":"10.1111","volume":"159","author":[{"given":"Raheel Altaf","family":"Raja","sequence":"first","affiliation":[{"name":"The Department of Paediatrics and Adolescent Medicine the University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjeld","family":"Schmiegelow","sequence":"additional","affiliation":[{"name":"The Department of Paediatrics and Adolescent Medicine the University Hospital Rigshospitalet Copenhagen Denmark"},{"name":"The 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