{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:45:44Z","timestamp":1789472744122,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T00:00:00Z","timestamp":1348185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"Summary<\/jats:title>\n \n T\u2010lymphoblastic leukaemia (\n T<\/jats:styled-content>\n \u2010\n ALL<\/jats:styled-content>\n ) and\n T<\/jats:styled-content>\n \u2010lymphoblastic lymphoma (\n T<\/jats:styled-content>\n \u2010\n LBL<\/jats:styled-content>\n ) are neoplasms derived from immature lymphoid cells of\n T<\/jats:styled-content>\n \u2010cell lineage. These neoplasms are biologically similar, but significant differences may exist between the two given their clinical differences. Although ample data regarding the immunophenotypic characterization\n T<\/jats:styled-content>\n \u2010\n ALL<\/jats:styled-content>\n are available, there is a paucity of such data in children and adolescents with\n T<\/jats:styled-content>\n \u2010\n LBL<\/jats:styled-content>\n . We used flow cytometry and\/or immunohistochemistry to characterize the immunophenotypic profile of 180 children and adolescents with newly diagnosed\n T<\/jats:styled-content>\n \u2010\n LBL<\/jats:styled-content>\n enrolled in the\n C<\/jats:styled-content>\n hildren's\n O<\/jats:styled-content>\n ncology\n G<\/jats:styled-content>\n roup 5971 study. Multiple\n T<\/jats:styled-content>\n \u2010cell,\n B<\/jats:styled-content>\n \u2010cell, myeloid, and other markers were evaluated. We identified diagnostically useful immunophenotypic features of\n T<\/jats:styled-content>\n \u2010\n LBL<\/jats:styled-content>\n as well as distinct immunophenotypic subgroups, although none of these was statistically related to event\u2010free or overall survival in this retrospective analysis. Further studies of biologically and immunophenotypically distinct subgroups of\n T<\/jats:styled-content>\n \u2010\n LBL<\/jats:styled-content>\n , such as the early\n T<\/jats:styled-content>\n \u2010cell precursor phenotype, are warranted.\n <\/jats:p>","DOI":"10.1111\/bjh.12042","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T03:52:10Z","timestamp":1348199530000},"page":"454-461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["The immunophenotype of\n T<\/scp>\n \u2010lymphoblastic lymphoma in children and adolescents: a\n C<\/scp>\n hildren's\n O<\/scp>\n ncology\n G<\/scp>\n roup report"],"prefix":"10.1111","volume":"159","author":[{"given":"Jay L.","family":"Patel","sequence":"first","affiliation":[{"name":"University of Calgary and Calgary Laboratory Services Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette M.","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Anderson","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minnie","family":"Abromowitch","sequence":"additional","affiliation":[{"name":"Children's Hospital and Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Campana","sequence":"additional","affiliation":[{"name":"National University of Singapore Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Lones","sequence":"additional","affiliation":[{"name":"Children's Hospital of Orange County\/St. Joseph Hospital Orange CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Gross","sequence":"additional","affiliation":[{"name":"Ohio State University School of Medicine Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell S.","family":"Cairo","sequence":"additional","affiliation":[{"name":"New York Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherrie L.","family":"Perkins","sequence":"additional","affiliation":[{"name":"University of Utah Health Sciences Center and ARUP Institute for Clinical and Experimental Pathology Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07320.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000146081"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06840"},{"key":"e_1_2_6_5_1","first-page":"1783","article-title":"Proposals for the immunological classification of acute leukemias. 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