{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:09:51Z","timestamp":1761059391959},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T00:00:00Z","timestamp":1347408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study aimed to evaluate bone remodelling disorders in thalassaemia by using pamidronate (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) infusion with or without hormone replacement therapy (<jats:styled-content style=\"fixed-case\">HRT<\/jats:styled-content>) as a diagnostic\u2010therapeutic tool. In this prospective study, 24 adult thalassaemia major (<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content>) and 10 thalassaemia intermedia (<jats:styled-content style=\"fixed-case\">TI<\/jats:styled-content>) patients received either <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HRT<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">HRT<\/jats:styled-content> only (controls) for 3\u00a0years. Eugonadal patients with <jats:styled-content style=\"fixed-case\">TI<\/jats:styled-content> had <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> only. Bone remodelling was assessed by dual energy <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content> ray absorptiometry (<jats:styled-content style=\"fixed-case\">DXA<\/jats:styled-content> scan), type 1\u2010collagen biochemical bone markers (<jats:styled-content style=\"fixed-case\">BBM<\/jats:styled-content>) and histomorphometry of iliac crest biopsy before and after <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>. As a group, thalassaemics had a significant improvement in spinal and femoral bone mineral density <jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content> scores following <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701) compared to the controls. Although <jats:styled-content style=\"fixed-case\">BBM<\/jats:styled-content> were comparable pre\u2010therapy, they were significantly lower in the <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> cohort (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) compared to the control group. All patients had osteopenia, diminished osteoid formation and bone volume on histomorphometry pre\u2010therapy with high turnover bone disease (<jats:styled-content style=\"fixed-case\">HTO<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content> and low\u2010turnover disease (<jats:styled-content style=\"fixed-case\">LTO<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">TI<\/jats:styled-content>. In <jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content>, bone volume improved significantly, whereas <jats:styled-content style=\"fixed-case\">TI<\/jats:styled-content> patients showed little or no response to <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>. In conclusion, histomorphometry data suggest that <jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content> patients have a distinct pathology of high turnover bone disease compared to <jats:styled-content style=\"fixed-case\">TI<\/jats:styled-content> patients, who have low\u2010turnover disease.<\/jats:p>","DOI":"10.1111\/bjh.12048","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T08:41:14Z","timestamp":1347439274000},"page":"462-471","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Prospective study of histomorphometry, biochemical bone markers and bone densitometric response to pamidronate in \u03b2\u2010thalassaemia presenting with osteopenia\u2010osteoporosis syndrome"],"prefix":"10.1111","volume":"159","author":[{"given":"Ratna","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Institute For Women's Health University College London London 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