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It is conspicuously different from classical <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>odgkin lymphoma (c<jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>) and is now recognized as distinctive form of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> cell lymphoma. Although it has an indolent clinical course, it has a propensity for multiple and often late relapses. Although the majority of children present with early stage disease and without <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> symptoms, treatment strategy has, until recently, been identical to that used for c<jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>. This approach is excessively toxic as it predisposes these children and adolescents to serious late effects including end organ damage to heart, gonads, lungs, thyroid and second malignant neoplasms. The aim of this article is to review the published literature on the treatment outcomes of n<jats:styled-content style=\"fixed-case\">LPHL<\/jats:styled-content> in affected children and adolescents, and discuss the options for treatment including surgery, chemotherapy, radiotherapy and targeted anti\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> 20 antibody therapy.<\/jats:p>","DOI":"10.1111\/bjh.12055","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T07:52:14Z","timestamp":1348213934000},"page":"288-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Nodular lymphocyte predominant <scp>H<\/scp>odgkin lymphoma in children and adolescents \u2013 a comprehensive review of biology, clinical course and treatment 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