{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T06:35:47Z","timestamp":1767162947826,"version":"build-2238731810"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    A recent meta\u2010analysis of three genome\u2010wide association studies of chronic lymphocytic leukaemia (\n                    <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\n                    ) identified two common variants at the 6p21.31 locus that are associated with\n                    <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\n                    risk. To verify and further explore the association of these variants with other non\u2010\n                    <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\n                    odgkin lymphoma (\n                    <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>\n                    ) subtypes, we genotyped 1196\n                    <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\n                    cases, 1699\n                    <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>\n                    cases, and 2410 controls. We found significant associations between the 6p21.31 variants and\n                    <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\n                    risk (rs210134:\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0\u00b701; rs210142:\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\n                    <jats:italic>\u00a0<\/jats:italic>\n                    6\u00b78\u00a0\u00d7\u00a010\n                    <jats:sup>\u22123<\/jats:sup>\n                    ). These variants also showed a trend towards association with some of the other\n                    <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>\n                    subtypes. Our results validate the prior work and support specific genetic pathways for risk among\n                    <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>\n                    subtypes.\n                  <\/jats:p>","DOI":"10.1111\/bjh.12070","type":"journal-article","created":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T12:35:10Z","timestamp":1349094910000},"page":"572-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non\u2010\n                    <scp>H<\/scp>\n                    odgkin lymphoma subtypes"],"prefix":"10.1111","volume":"159","author":[{"given":"Susan L.","family":"Slager","sequence":"first","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola J.","family":"Camp","sequence":"additional","affiliation":[{"name":"University of Utah School of Medicine Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Conde","sequence":"additional","affiliation":[{"name":"Division of Environmental Health Sciences School of Public Health University of California Berkeley Berkeley CA CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tait D.","family":"Shanafelt","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara J.","family":"Achenbach","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari G.","family":"Rabe","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil E.","family":"Kay","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne J.","family":"Novak","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy G.","family":"Call","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paige M.","family":"Bracci","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Medicine University of California San Francisco San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenna M. C.","family":"Sille","sequence":"additional","affiliation":[{"name":"Division of Environmental Health Sciences School of Public Health University of California Berkeley Berkeley CA CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Division of Environmental Health Sciences School of Public Health University of California Berkeley Berkeley CA CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas K.","family":"Akers","sequence":"additional","affiliation":[{"name":"Division of Environmental Health Sciences School of Public Health University of California Berkeley Berkeley CA CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie M.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Serie","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon K.","family":"McDonnell","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose F.","family":"Leis","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice H.","family":"Wang","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Brice","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Durham NC USA"},{"name":"Durham, NC VA Medical Center Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Glenn","sequence":"additional","affiliation":[{"name":"University of Utah School of Medicine Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Link","sequence":"additional","affiliation":[{"name":"University of Iowa College of Medicine Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celine M.","family":"Vachon","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark C.","family":"Lanasa","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine F.","family":"Skibola","sequence":"additional","affiliation":[{"name":"Division of Environmental Health Sciences School of Public Health University of California Berkeley Berkeley CA CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Cerhan","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"119","article-title":"The World Health Organization (WHO) classification of lymphoid neoplasms: what's new?","volume":"19","author":"Harris N.L.","year":"2008","journal-title":"Annals of Oncology"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.86"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-010-0925-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.107524.110"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-308205"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-413591"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.467"},{"key":"e_1_2_7_10_1","volume-title":"World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues; Volume 2 of WHO Classification of Tumours Series","author":"Swerdlow S.H.","year":"2008"}],"updated-by":[{"DOI":"10.1111\/bjh.12211","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T00:00:00Z","timestamp":1360886400000}}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.12070","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.12070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T01:26:55Z","timestamp":1700530015000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.12070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/bjh.12070"],"URL":"https:\/\/doi.org\/10.1111\/bjh.12070","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"2012-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-08-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}