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At baseline, thalassaemic <jats:styled-content style=\"fixed-case\">PBL<\/jats:styled-content>s presented 50% greater levels of Bax (<jats:styled-content style=\"fixed-case\">BAX<\/jats:styled-content>), 75% higher caspase\u20103\/7, 48% higher caspase\u20108 and 88% higher caspase\u20109 activities and 428% more nucleosomal <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> fragmentation than control subjects. Only neutrophils correlated significantly with apoptotic markers. Previously, we showed that over the treatment year, hepatic iron declined; we now show that the ratio of Bax\/Bcl\u20102 (<jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>2), (\u221227\u00b73%\/year), and caspase\u20109 activity (\u221213\u00b73%\/year) declined in both treatment groups, suggesting that chelation decreases body iron and indicators of <jats:styled-content style=\"fixed-case\">PBL<\/jats:styled-content> apoptosis.<\/jats:p>","DOI":"10.1111\/bjh.12076","type":"journal-article","created":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T13:52:24Z","timestamp":1354801944000},"page":"399-403","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Increased leucocyte apoptosis in transfused \u03b2\u2010thalassaemia patients"],"prefix":"10.1111","volume":"160","author":[{"given":"Patrick B.","family":"Walter","sequence":"first","affiliation":[{"name":"Children's Hospital &amp; Research Center Oakland Oakland CA USA"},{"name":"Department of Biology University of Victoria Victoria Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Porter","sequence":"additional","affiliation":[{"name":"University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Evans","sequence":"additional","affiliation":[{"name":"University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet L.","family":"Kwiatkowski","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellis J.","family":"Neufeld","sequence":"additional","affiliation":[{"name":"Children's Hospital Boston Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Coates","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia J.","family":"Giardina","sequence":"additional","affiliation":[{"name":"New York\u2010Presbyterian Hospital New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Grady","sequence":"additional","affiliation":[{"name":"New York\u2010Presbyterian Hospital New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliott","family":"Vichinsky","sequence":"additional","affiliation":[{"name":"Children's Hospital &amp; 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