{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:15:54Z","timestamp":1790748954613,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T00:00:00Z","timestamp":1350518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Mastocytosis is a rare disease with reported high interleukin\u20106 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>6) levels influencing disease severity. The present study investigated polymorphisms within the genes that encode <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>6 and its receptor (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>6<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>) in relation to mastocytosis development in a case\u2010control design. Analysis of the <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>6<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content><\/jats:italic> Asp358Ala polymorphism showed that carriers of the <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> genotype had a 2\u00b75\u2010fold lower risk for mastocytosis than those with the <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> genotypes. No association with mastocytosis was found for the <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>6<\/jats:italic>\u2212174<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> polymorphism, however, it may influence the effect of <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>6<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content><\/jats:italic> polymorphism. To the best of our knowledge this is the first study analysing <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>6\/<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>6<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content><\/jats:italic> polymorphisms in mastocytosis.<\/jats:p>","DOI":"10.1111\/bjh.12086","type":"journal-article","created":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T21:55:37Z","timestamp":1350597337000},"page":"216-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparative analysis of <scp>IL<\/scp>6 and <scp>IL<\/scp>6 receptor gene polymorphisms in mastocytosis"],"prefix":"10.1111","volume":"160","author":[{"given":"Eszter","family":"Rausz","sequence":"first","affiliation":[{"name":"PhD School Semmelweis University of Medicine Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Szil\u00e1gyi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boguslaw","family":"Nedoszytko","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Gdansk Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Allergology Medical University of Gdansk Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Niedoszytko","sequence":"additional","affiliation":[{"name":"Department of Allergology Medical University of Gdansk Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orsolya","family":"Lautner\u2010Csorba","sequence":"additional","affiliation":[{"name":"Department of Genetics Cell\u2010and Immunobiology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Falus","sequence":"additional","affiliation":[{"name":"Department of Genetics Cell\u2010and Immunobiology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"Aladzsity","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rta","family":"Kokai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Valent","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Division of Haematology &amp; 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