{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:52:12Z","timestamp":1790657532474,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T00:00:00Z","timestamp":1351036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"Summary<\/jats:title>\n \n Serum free light\n C<\/jats:styled-content>\n hain (s\n FLC<\/jats:styled-content>\n ) ratios have been correlated with survival outcomes in\n H<\/jats:styled-content>\n odgkin and non\u2010\n H<\/jats:styled-content>\n odgkin lymphoma subtypes. This study was undertaken to investigate the prognostic impact of abnormal s\n FLC<\/jats:styled-content>\n ratios in mantle cell lymphoma (\n MCL<\/jats:styled-content>\n ). two patient cohorts were analysed for s\n FLC<\/jats:styled-content>\n parameters: a preliminary retrospective cohort and a uniformly treated cohort of 20 relapsed\/refractory\n MCL<\/jats:styled-content>\n patients, enrolled in a phase II clinical trial of single agent lenalidomide treatment. 52% of patients had an abnormality of one or more s\n FLC<\/jats:styled-content>\n parameter (71% of the first cohort and 40% of the second cohort). In cohort two, a high baseline\n SFLC<\/jats:styled-content>\n ratio correlated with poorer overall survival (\n OS<\/jats:styled-content>\n ) compared to a low\/normal ratio (median\n OS<\/jats:styled-content>\n : 1\u00b74\u00a0months vs. 19\u00a0months respectively;\n P<\/jats:italic>\n \u00a0=\u00a00\u00b7001). For patients presenting with an elevated s\n FLC<\/jats:styled-content>\n ratio at trial entry a rise of >35% in the s\n FLC<\/jats:styled-content>\n ratio correlated with disease progression and a s\n FLC<\/jats:styled-content>\n ratio of >2\u00d7 normal at trial entry correlated with aggressive disease. These data are the first to show a clear clinical correlation between s\n FLC<\/jats:styled-content>\n ratios and survival outcomes in a uniformly treated cohort of\n MCL<\/jats:styled-content>\n patients. We suggest that these markers may be useful in managing patients with\n MCL<\/jats:styled-content>\n in the future.\n <\/jats:p>","DOI":"10.1111\/bjh.12094","type":"journal-article","created":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T03:02:33Z","timestamp":1351047753000},"page":"63-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Abnormal serum free light chain ratio predicts poor overall survival in mantle cell lymphoma"],"prefix":"10.1111","volume":"160","author":[{"given":"Michelle","family":"Furtado","sequence":"first","affiliation":[{"name":"Derriford Hospital Plymouth Devon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimish","family":"Shah","sequence":"additional","affiliation":[{"name":"Derriford Hospital Plymouth Devon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Levoguer","sequence":"additional","affiliation":[{"name":"The 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