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These criteria have been updated in light of further data demonstrating an improvement in categorical responses with new drug regimens as well as acknowledgement of the fact that such responses are predictive of overall outcome. A number of key changes are proposed but challenges do however remain and these include the variability in kinetics of immunoglobulin <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">IgM<\/jats:styled-content>) reduction with different treatment modalities and the apparent discrepancy between <jats:styled-content style=\"fixed-case\">IgM<\/jats:styled-content> and bone marrow\/tissue response noted with some regimens. Planned sequential bone marrow assessments are encouraged in clinical trials.<\/jats:p>","DOI":"10.1111\/bjh.12102","type":"journal-article","created":{"date-parts":[[2012,11,15]],"date-time":"2012-11-15T18:31:59Z","timestamp":1353004319000},"page":"171-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":272,"title":["Response assessment in <scp>W<\/scp>aldenstr\u00f6m macroglobulinaemia: update from the <scp>VI<\/scp>th <scp>I<\/scp>nternational <scp>W<\/scp>orkshop"],"prefix":"10.1111","volume":"160","author":[{"given":"Roger G.","family":"Owen","sequence":"first","affiliation":[{"name":"St James's University Hospital Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Kyle","sequence":"additional","affiliation":[{"name":"Mayo School of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin 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