{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:26:30Z","timestamp":1761895590708},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,11,15]],"date-time":"2012-11-15T00:00:00Z","timestamp":1352937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We analysed the long\u2010term outcomes of 60 multiple myeloma patients who underwent reduced intensity allogeneic stem cell transplantation between <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ugust 2000 and <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch 2008. Regimens included fludarabine and melphalan conditioning (flu\u2010mel regimen) for allogeneic haematopoietic cell transplant (<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>) or a planned tandem regimen consisting of high\u2010dose melphalan conditioning for autograft followed by low\u2010dose total body irradiation conditioning for allogeneic <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> (auto\u2010allo regimen). Donors included human\u2010leucocyte\u2010antigen\u2010matched siblings (<jats:italic>n<\/jats:italic>\u00a0=\u00a055) or matched unrelated donors (<jats:italic>n<\/jats:italic>\u00a0=\u00a05). With a median follow\u2010up of 9\u00b78\u00a0years, 7\u2010year overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) and progression\u2010free survival (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>) were 60% and 31%, respectively. By multivariate <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ox regression analysis, disease status of complete response (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) or partial response (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>) at transplant and the presence of chronic graft\u2010<jats:italic>versus<\/jats:italic>\u2010host disease were significantly associated with improved <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>. Only disease status was significantly associated with improved <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>. We noted a surprising number of very late relapses, with six patients (10%) relapsing between 6 and 12\u00a0years post\u2010transplant. Among the six late relapse patients, all were transplanted within 14\u00a0months of diagnosis, five had normal karyotypes, and five were in <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>. Our data provide additional evidence that, while survival may be extended by reduced intensity allogeneic transplant, ultimately, it may not offer a cure.<\/jats:p>","DOI":"10.1111\/bjh.12123","type":"journal-article","created":{"date-parts":[[2012,11,15]],"date-time":"2012-11-15T18:51:54Z","timestamp":1353005514000},"page":"199-206","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Late relapses following reduced intensity allogeneic transplantation in patients with multiple myeloma: a long\u2010term follow\u2010up study"],"prefix":"10.1111","volume":"160","author":[{"given":"Firoozeh","family":"Sahebi","sequence":"first","affiliation":[{"name":"Department of Hematology City of Hope National Medical Center Duarte CA USA"},{"name":"Transplant Program Southern California Kaiser Permanente Medical Group Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Information Sciences City of Hope National Medical Center Duarte CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra H.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Hematology City of Hope National Medical Center Duarte CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amalia","family":"Rincon","sequence":"additional","affiliation":[{"name":"Department of Information Sciences City of Hope National Medical Center Duarte CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Murata\u2010Collins","sequence":"additional","affiliation":[{"name":"Department of Cytogenetics City of Hope National Medical Center Duarte CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joycelynne","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Information Sciences City of Hope National Medical Center Duarte CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amrita Y.","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Hematology City of Hope National Medical Center Duarte CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chatchada","family":"Karanes","sequence":"additional","affiliation":[{"name":"Department of Hematology City of Hope National Medical Center Duarte CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myo","family":"Htut","sequence":"additional","affiliation":[{"name":"Department of Hematology City of Hope National Medical Center Duarte CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Somlo","sequence":"additional","affiliation":[{"name":"Department of Hematology City of Hope National Medical Center Duarte CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Forman","sequence":"additional","affiliation":[{"name":"Department of Hematology City of Hope National Medical Center Duarte CA 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