{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:19:13Z","timestamp":1793272753773,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,12,24]],"date-time":"2012-12-24T00:00:00Z","timestamp":1356307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The combination of interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20104 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 protects against blood\u2010induced cartilage damage <jats:italic>in vitro<\/jats:italic>. It has been hypothesized that the combination of these cytokines is effective if applied early in the process of cartilage damage. The present study investigated whether a single intra\u2010articular injection of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 plus <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 immediately after a joint bleed limits cartilage damage in an <jats:italic>in vivo<\/jats:italic> haemophilia mouse model of blood\u2010induced joint damage. Factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content> knockout mice with severe haemophilia A were punctured once with a needle below the patella to induce a joint haemorrhage. Subsequently <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 plus <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 (<jats:italic>n\u00a0<\/jats:italic>=\u00a024) or vehicle (<jats:italic>n<\/jats:italic>\u00a0=\u00a024) was injected intra\u2010articularly. After 35\u00a0days, the time needed for development of detectable joint degeneration, knee joints were examined for cartilage damage by macroscopic and microscopic evaluation. A single intra\u2010articular injection of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 plus <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 ameliorated progression of cartilage degeneration caused by a single joint bleed to a certain extent. No effect on inflammation was observed at this time point. A single intra\u2010articular injection of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 plus Il\u201010 directly after a single joint bleed limits progression of cartilage degeneration over time. Improved bioavailability (half\u2010life) of both cytokines might improve their protective ability in the development of cartilage degeneration, and probably also inflammation.<\/jats:p>","DOI":"10.1111\/bjh.12148","type":"journal-article","created":{"date-parts":[[2012,12,24]],"date-time":"2012-12-24T07:23:17Z","timestamp":1356333797000},"page":"515-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["A single intra\u2010articular injection with <scp>IL<\/scp>\u20104 plus <scp>IL<\/scp>\u201010 ameliorates blood\u2010induced cartilage degeneration in haemophilic mice"],"prefix":"10.1111","volume":"160","author":[{"given":"Monique E. R.","family":"van Meegeren","sequence":"first","affiliation":[{"name":"Department of Rheumatology &amp; Clinical Immunology University Medical Centre Utrecht Utrecht The Netherlands"},{"name":"Department of Haematology and Van Creveld Clinic University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goris","family":"Roosendaal","sequence":"additional","affiliation":[{"name":"Department of Haematology and Van Creveld Clinic University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Coeleveld","sequence":"additional","affiliation":[{"name":"Department of Rheumatology &amp; Clinical Immunology University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurens","family":"Nieuwenhuizen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology &amp; Clinical Immunology University Medical Centre Utrecht Utrecht The Netherlands"},{"name":"Department of Haematology and Van Creveld Clinic University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon C.","family":"Mastbergen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology &amp; Clinical Immunology University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris P. J. G.","family":"Lafeber","sequence":"additional","affiliation":[{"name":"Department of Rheumatology &amp; Clinical Immunology University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0595-119"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.9.3446.bloodjournal8893446"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.4049\/jimmunol.147.11.3815","article-title":"IL\u201010 inhibits cytokine production by activated macrophages","volume":"147","author":"Fiorentino D.F.","year":"1991","journal-title":"Journal of Immunology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00545.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.05.025"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22034"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4231"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01689.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63889-8"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg220"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.4049\/jimmunol.159.11.5687","article-title":"Suppression of collagen\u2010induced arthritis by continuous administration of IL\u20104","volume":"159","author":"Horsfall A.C.","year":"1997","journal-title":"Journal of Immunology"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(97)90065-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07278.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.09.001"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar14"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1997.0298"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.4049\/jimmunol.163.8.4546","article-title":"Adenoviral vector\u2010mediated overexpression of IL\u20104 in the knee joint of mice with collagen\u2010induced arthritis prevents cartilage destruction","volume":"163","author":"Lubberts E.","year":"1999","journal-title":"Journal of Immunology"},{"key":"e_1_2_7_19_1","first-page":"11","article-title":"Animal models of osteoarthritis \u2010 Why choose a larger model?","volume":"4","author":"Mastbergen S.C.","year":"2009","journal-title":"US Musculoskeletal Review"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.04.002"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330913"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01973.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.1996.d01-355.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2010.1.191"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(93)90108-R"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011918425629"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200101)44:1<3::AID-ANR2>3.0.CO;2-U"},{"key":"e_1_2_7_28_1","first-page":"1350","article-title":"Cartilage damage as a result of hemarthrosis in a human in vitro model","volume":"24","author":"Roosendaal G.","year":"1997","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199905)42:5<1025::AID-ANR23>3.0.CO;2-3"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01348.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01870.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.7.1392.1392"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.5.1209"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0390"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.12148","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.12148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T11:35:49Z","timestamp":1697628949000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.12148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,24]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/bjh.12148"],"URL":"https:\/\/doi.org\/10.1111\/bjh.12148","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,24]]},"assertion":[{"value":"2012-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-12-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}