{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:37:21Z","timestamp":1780792641428,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,12,30]],"date-time":"2012-12-30T00:00:00Z","timestamp":1356825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Pain is not a symptom generally associated with thalassaemia. However, providers have noted increasing patient reports of pain, creating an impetus for this prospective, observational assessment of pain in thalassaemia patients. The primary study goals were to assess pain prevalence, severity, location, and potential risk factors. This was a multicentre, prospective study of thalassaemia patients receiving care at 12 Thalassaemia Clinical Research Network sites. Pain was assessed using the Brief Pain Inventory. Two hundred and fifty\u2010two thalassaemia patients ranging in age from 12 to 71\u00a0years (mean 28\u00b78) were enrolled. Sixty\u2010four per\u00a0cent reported experiencing pain during the last 4\u00a0weeks, 22% of whom reported pain on a daily basis. Ordinal regression analysis of pain ratings demonstrated significant (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00\u00b7001) correlation of increased age with increased pain, irrespective of diagnosis, transfusion status, gender, bone density, chelator type or iron overload. Eighty\u2010one per\u00a0cent reported having pain for 1\u00a0year or longer and 31% reported pain for five or more years. Pain is a major cause of morbidity and an unrecognized problem for patients with thalassaemia. Age is the strongest predictor of frequency and severity. Little else is known about the aetiology and predictors of this pain syndrome.<\/jats:p>","DOI":"10.1111\/bjh.12177","type":"journal-article","created":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T12:55:54Z","timestamp":1357044954000},"page":"680-687","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Pain in thalassaemia: the effects of age on pain frequency and severity"],"prefix":"10.1111","volume":"160","author":[{"given":"Dru","family":"Haines","sequence":"first","affiliation":[{"name":"Hematology\/Oncology Department Children's Hospital &amp; Research Center Oakland Oakland CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Martin","sequence":"additional","affiliation":[{"name":"Division of Hematology Children's Hospital of Philadelphia Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Carson","sequence":"additional","affiliation":[{"name":"Pediatric Hematology Children's Hospital Los Angeles Keck School of Medicine University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Oliveros","sequence":"additional","affiliation":[{"name":"Hematology\/Oncology Department Children's Hospital &amp; Research Center Oakland Oakland CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sage","family":"Green","sequence":"additional","affiliation":[{"name":"Division of Hematology Children's Hospital of Philadelphia Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Coates","sequence":"additional","affiliation":[{"name":"Pediatric Hematology Children's Hospital Los Angeles Keck School of Medicine University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Eile","sequence":"additional","affiliation":[{"name":"Division of Hematology Children's Hospital Boston Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leann","family":"Schilling","sequence":"additional","affiliation":[{"name":"Hematology Department Children's Healthcare of Atlanta at Scottish Rite Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogan","family":"Dinu","sequence":"additional","affiliation":[{"name":"Hematology\/Oncology Department Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tito","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Department of Symptomatic Research MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Gerstenberger","sequence":"additional","affiliation":[{"name":"Center for Statistical Analysis and Research New England Research Institutes Watertown MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Trachtenberg","sequence":"additional","affiliation":[{"name":"Center for Statistical Analysis and Research New England Research Institutes Watertown MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott","family":"Vichinsky","sequence":"additional","affiliation":[{"name":"Hematology\/Oncology Department Children's Hospital &amp; Research Center Oakland Oakland CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for The Thalassemia Clinical Research Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.09.027"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(02)00516-X"},{"key":"e_1_2_7_4_1","first-page":"63","volume-title":"The Brief Pain Inventory. 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