{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T05:19:40Z","timestamp":1776835180930,"version":"3.51.2"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study, conducted for the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> Blood Transfusion Services (<jats:styled-content style=\"fixed-case\">UKBTS<\/jats:styled-content>), evaluated the clinical safety of red cells filtered through a <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>\u2010marked prion removal filter (P\u2010Capt\u2122). Patients requiring blood transfusion for elective procedures in nine <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> hospitals were entered into a non\u2010randomized open trial to assess development of red cell antibodies to standard red cell (<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>) or prion\u2010filtered red cell concentrates (<jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>) at eight weeks and six months post\u2010transfusion. Patients who received at least 1\u00a0unit of <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> were compared with a control cohort given <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> only. About 917 <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> and 1336 <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> units were transfused into 299 and 291 patients respectively. Twenty\u2010six new red cell antibodies were detected post\u2010transfusion in 10 patients in each arm, an overall alloimmunization rate of 4\u00b74%. Neither the treatment arm [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 0\u00b793, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 0\u00b73, 2\u00b75] nor number of units transfused (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0\u00b795, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0\u00b78, 1\u00b71) had a significant effect on the proportion of patients who developed new alloantibodies. No pan\u2010reactive antibodies or antibodies specifically against <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> were detected. There was no difference in transfusion reactions between arms, and no novel transfusion\u2010related adverse events clearly attributable to <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> were seen. These data suggest that prion filtration of red cells does not reduce overall transfusion safety. This finding requires confirmation in large populations of transfused patients.<\/jats:p>","DOI":"10.1111\/bjh.12188","type":"journal-article","created":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T13:32:07Z","timestamp":1357565527000},"page":"701-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Transfusion of prion\u2010filtered red cells does not increase the rate of alloimmunization or transfusion reactions in patients: results of the <scp>UK<\/scp> trial of prion\u2010filtered <i>versus<\/i> standard red cells in surgical patients (PRISM A)"],"prefix":"10.1111","volume":"160","author":[{"given":"Modupe O.","family":"Elebute","sequence":"first","affiliation":[{"name":"Department of Haematology King's College Hospital London UK"},{"name":"NHS Blood &amp; Transplant Watford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Choo","sequence":"additional","affiliation":[{"name":"MRC Clinical Trials Unit London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Mora","sequence":"additional","affiliation":[{"name":"NHS Blood &amp; Transplant\/MRC Clinical Studies Unit Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coral","family":"MacRury","sequence":"additional","affiliation":[{"name":"Scottish National Blood Transfusion Service Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Llewelyn","sequence":"additional","affiliation":[{"name":"NHS Blood &amp; Transplant\/MRC Clinical Studies Unit Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpi","family":"Purohit","sequence":"additional","affiliation":[{"name":"NHS Blood &amp; Transplant Watford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicky","family":"Hicks","sequence":"additional","affiliation":[{"name":"NHS Blood &amp; Transplant Watford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Casey","sequence":"additional","affiliation":[{"name":"Scottish National Blood Transfusion Service Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moira","family":"Malfroy","sequence":"additional","affiliation":[{"name":"NHS Blood &amp; Transplant\/MRC Clinical Studies Unit Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Deary","sequence":"additional","affiliation":[{"name":"NHS Blood &amp; Transplant\/MRC Clinical Studies Unit Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Reed","sequence":"additional","affiliation":[{"name":"NHS Blood &amp; Transplant\/MRC Clinical Studies Unit Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Meredith","sequence":"additional","affiliation":[{"name":"MRC Clinical Trials Unit London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Manson","sequence":"additional","affiliation":[{"name":"Scottish National Blood Transfusion Service Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorna M.","family":"Williamson","sequence":"additional","affiliation":[{"name":"NHS Blood &amp; Transplant Watford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2010.01330.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03133.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1996.361097017177.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015626"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2002.2313"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16812-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00865.x"},{"key":"e_1_2_7_9_1","first-page":"77A","article-title":"Post transfusion \u201cred eye\u201d syndrome: discovery, investigation, and control [abstract]","volume":"1998","author":"Haley N.R.","year":"1998","journal-title":"Transfusion"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2006.00833.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2002.00401_2.x"},{"key":"e_1_2_7_12_1","unstructured":"ICH(1996)Guideline For Good Clinical Practice; ICH Harmonised Tripartite Guideline. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Geneva Switzerland.http:\/\/www.ich.org\/fileadmin\/Public_Web_Site\/ICH_Products\/Guidelines\/Efficacy\/E6_R1\/Step4\/E6_R1__Guideline.pdf"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15486-X"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2009.00918.x"},{"key":"e_1_2_7_15_1","volume-title":"Guidelines for the Blood Transfusion Services in the United Kingdom","author":"National Blood Service","year":"2005"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16811-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.1996.7140216.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1998.38498257382.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41080997.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00390.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.04116.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02500.x"}],"updated-by":[{"DOI":"10.1111\/bjh.12312","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,4,11]],"date-time":"2013-04-11T00:00:00Z","timestamp":1365638400000}}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.12188","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.12188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:59:59Z","timestamp":1700614799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.12188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,7]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/bjh.12188"],"URL":"https:\/\/doi.org\/10.1111\/bjh.12188","archive":["Portico"],"relation":{"correction":[{"id-type":"doi","id":"10.1111\/bjh.12312","asserted-by":"object"}]},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,7]]},"assertion":[{"value":"2012-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-11-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}